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64 results

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Page 1
MTMR3 risk alleles enhance Toll Like Receptor 9-induced IgA immunity in IgA nephropathy.
Wang YN, Gan T, Qu S, Xu LL, Hu Y, Liu LJ, Shi SF, Lv JC, Tsoi LC, Patrick MT, He K, Berthier CC, Xu HJ, Zhou XJ, Zhang H. Wang YN, et al. Kidney Int. 2023 Sep;104(3):562-576. doi: 10.1016/j.kint.2023.06.018. Epub 2023 Jul 4. Kidney Int. 2023. PMID: 37414396
Consistently, elevated MTMR3 expression in peripheral blood mononuclear cells was observed in patients with IgAN. ...Thus, our results support the role of MTMR3 in IgAN pathogenesis by enhancing Toll Like Receptor 9-induced IgA immunity....
Consistently, elevated MTMR3 expression in peripheral blood mononuclear cells was observed in patients with IgAN. ...Thus, our result …
New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD.
Larabi A, Barnich N, Nguyen HTT. Larabi A, et al. Autophagy. 2020 Jan;16(1):38-51. doi: 10.1080/15548627.2019.1635384. Epub 2019 Jul 9. Autophagy. 2020. PMID: 31286804 Free PMC article. Review.
A better understanding of the role of autophagy in IBD pathogenesis may provide better sub-classification of IBD phenotypes and novel approaches for disease management.Abbreviations: AIEC: adherent-invasive Escherichia coli; AMPK: AMP-activated protein kinase; ATF6: activating tr …
A better understanding of the role of autophagy in IBD pathogenesis may provide better sub-classification of IBD phenotypes and novel approa …
MTMR3 is upregulated in patients with breast cancer and regulates proliferation, cell cycle progression and autophagy in breast cancer cells.
Wang Z, Zhang M, Shan R, Wang YJ, Chen J, Huang J, Sun LQ, Zhou WB. Wang Z, et al. Oncol Rep. 2019 Nov;42(5):1915-1923. doi: 10.3892/or.2019.7292. Epub 2019 Aug 23. Oncol Rep. 2019. PMID: 31485632 Free PMC article.
MTMR3 was highly expressed in triple-negative breast cancer and was associated with disease recurrence. MTMR3 knockdown in MDA-MB-231 cells inhibited cell proliferation and induced cell cycle arrest and autophagy. ...
MTMR3 was highly expressed in triple-negative breast cancer and was associated with disease recurrence. MTMR3 knockdown in MDA …
The PtdIns3-phosphatase MTMR3 interacts with mTORC1 and suppresses its activity.
Hao F, Itoh T, Morita E, Shirahama-Noda K, Yoshimori T, Noda T. Hao F, et al. FEBS Lett. 2016 Jan;590(1):161-73. doi: 10.1002/1873-3468.12048. Epub 2015 Dec 31. FEBS Lett. 2016. PMID: 26787466 Free PMC article.
Furthermore, overexpression of MTMR3 inhibited mTORC1 activity. The N-terminal half of MTMR3, including the PH-G and phosphatase domains, was necessary and sufficient for these effects. Phosphatase-deficient MTMR3 provided more robust suppression of mTORC1 ac …
Furthermore, overexpression of MTMR3 inhibited mTORC1 activity. The N-terminal half of MTMR3, including the PH-G and phosphata …
MTMR3 risk allele enhances innate receptor-induced signaling and cytokines by decreasing autophagy and increasing caspase-1 activation.
Lahiri A, Hedl M, Abraham C. Lahiri A, et al. Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):10461-6. doi: 10.1073/pnas.1501752112. Epub 2015 Aug 3. Proc Natl Acad Sci U S A. 2015. PMID: 26240347 Free PMC article.
Multiple genetic loci are associated with IBD, but altered functions for most, including in the rs713875 MTMR3/HORMAD2/LIF/OSM region, are unknown. We identified a previously undefined role for myotubularin-related protein 3 (MTMR3) in amplifying PRR-induced cytokin …
Multiple genetic loci are associated with IBD, but altered functions for most, including in the rs713875 MTMR3/HORMAD2/LIF/OSM region …
PIKfyve, MTMR3 and their product PtdIns5P regulate cancer cell migration and invasion through activation of Rac1.
Oppelt A, Haugsten EM, Zech T, Danielsen HE, Sveen A, Lobert VH, Skotheim RI, Wesche J. Oppelt A, et al. Biochem J. 2014 Aug 1;461(3):383-90. doi: 10.1042/BJ20140132. Biochem J. 2014. PMID: 24840251
Mechanistically, we show that PIKfyve and MTMR3 regulate the activation of the Rho family GTPase Rac1. Further experiments also implicated PtdIns5P in the activation of Rac1. ...Finally, in an invasion assay, we demonstrate that both PIKfyve and MTMR3 are implicated …
Mechanistically, we show that PIKfyve and MTMR3 regulate the activation of the Rho family GTPase Rac1. Further experiments also impli …
Association of MTMR3 rs12537 at miR-181a binding site with rheumatoid arthritis and systemic lupus erythematosus risk in Egyptian patients.
Senousy MA, Helmy HS, Fathy N, Shaker OG, Ayeldeen GM. Senousy MA, et al. Sci Rep. 2019 Aug 23;9(1):12299. doi: 10.1038/s41598-019-48770-5. Sci Rep. 2019. PMID: 31444373 Free PMC article.
Single nucleotide polymorphisms (SNPs) in microRNA-target sites influence an individual's risk and prognosis for autoimmune diseases. Myotubularin-related protein 3 (MTMR3), an autophagy-related gene, is a direct target of miR-181a. We investigated whether MTMR3 SNP …
Single nucleotide polymorphisms (SNPs) in microRNA-target sites influence an individual's risk and prognosis for autoimmune diseases. Myotub …
PtdIns3P phosphatases MTMR3 and MTMR4 negatively regulate innate immune responses to DNA through modulating STING trafficking.
Dewi Pamungkas Putri D, Kawasaki T, Murase M, Sueyoshi T, Deguchi T, Ori D, Suetsugu S, Kawai T. Dewi Pamungkas Putri D, et al. J Biol Chem. 2019 May 24;294(21):8412-8423. doi: 10.1074/jbc.RA118.005731. Epub 2019 Apr 3. J Biol Chem. 2019. PMID: 30944173 Free PMC article.
Here we found that STING trafficking is regulated by myotubularin-related protein (MTMR) 3 and MTMR4, members of protein tyrosine phosphatases that dephosphorylate 3' position in phosphatidylinositol (PtdIns) and generate PtdIns5P from PtdIns3,5P(2) and PtdIns from PtdIns3P. We e …
Here we found that STING trafficking is regulated by myotubularin-related protein (MTMR) 3 and MTMR4, members of protein tyrosine phosphatas …
miR-100-5p Promotes Epidermal Stem Cell Proliferation through Targeting MTMR3 to Activate PIP3/AKT and ERK Signaling Pathways.
Liu Z, Yang Y, Ju J, Zhang G, Zhang P, Ji P, Jin Q, Cao G, Zuo R, Wang H, Yu C, Zhang Z, Le Y, Fu Y, Hou R. Liu Z, et al. Stem Cells Int. 2022 Aug 21;2022:1474273. doi: 10.1155/2022/1474273. eCollection 2022. Stem Cells Int. 2022. PMID: 36045954 Free PMC article.
Overexpression of MTMR3 reversed the proproliferative effect of miR-100-5p on EpSCs, indicating that miR-100-5p promoted EpSC proliferation by downregulating MTMR3. ...The aforementioned effect of miR-100-5p-enriched ADSC-Exos was stronger than that of ADSC-Exos and …
Overexpression of MTMR3 reversed the proproliferative effect of miR-100-5p on EpSCs, indicating that miR-100-5p promoted EpSC prolife …
Breast cancer risk is associated with the HULC rs7763881, MTMR3 rs12537 polymorphisms, and serum levels of HULC and MTMR3 in Egyptian patients.
Elhelaly M, Shaker OG, Ayeldeen G, Elsergany AR, Mostafa N. Elhelaly M, et al. Mol Biol Rep. 2023 Dec;50(12):10073-10081. doi: 10.1007/s11033-023-08897-1. Epub 2023 Nov 1. Mol Biol Rep. 2023. PMID: 37910386 Free PMC article.
Positive correlation between MTMR3 and HULC. MTMR3 and ALT, as well as HULC and alkaline phosphatase, both showed a statistically significant positive correlation. CONCLUSION: Our findings reveal that MTMR3 and HULC serum expression and their SNPs (HULC rs776 …
Positive correlation between MTMR3 and HULC. MTMR3 and ALT, as well as HULC and alkaline phosphatase, both showed a statistica …
64 results