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32 results

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The myotubularin MTMR4 regulates phagosomal phosphatidylinositol 3-phosphate turnover and phagocytosis.
Sheffield DA, Jepsen MR, Feeney SJ, Bertucci MC, Sriratana A, Naughtin MJ, Dyson JM, Coppel RL, Mitchell CA. Sheffield DA, et al. J Biol Chem. 2019 Nov 8;294(45):16684-16697. doi: 10.1074/jbc.RA119.009133. Epub 2019 Sep 22. J Biol Chem. 2019. PMID: 31543504 Free PMC article.
We report here that a myotubularin PtdIns(3)P 3-phosphatase, myotubularin-related protein-4 (MTMR4), regulates macrophage phagocytosis. MTMR4 overexpression reduced and siRNA-mediated Mtmr4 silencing increased levels of cell-surface immunoglobulin receptors ( …
We report here that a myotubularin PtdIns(3)P 3-phosphatase, myotubularin-related protein-4 (MTMR4), regulates macrophage phagocytosi …
MTMR4 Is Required for the Stability of the Salmonella-Containing Vacuole.
Teo WX, Kerr MC, Teasdale RD. Teo WX, et al. Front Cell Infect Microbiol. 2016 Aug 30;6:91. doi: 10.3389/fcimb.2016.00091. eCollection 2016. Front Cell Infect Microbiol. 2016. PMID: 27625994 Free PMC article.
While the phosphoinositide 3-phosphatase myotubularin 4 (MTMR4) has an established role in regulating autophagy and cellular PI(3)P-content, two processes associated with the intracellular survival of S. typhimurium, a direct role for MTMR4 in Salmonella biology has …
While the phosphoinositide 3-phosphatase myotubularin 4 (MTMR4) has an established role in regulating autophagy and cellular PI(3)P-c …
MTMR4 SNVs modulate ion channel degradation and clinical severity in congenital long QT syndrome: insights in the mechanism of action of protective modifier genes.
Lee YK, Sala L, Mura M, Rocchetti M, Pedrazzini M, Ran X, Mak TSH, Crotti L, Sham PC, Torre E, Zaza A, Schwartz PJ, Tse HF, Gnecchi M. Lee YK, et al. Cardiovasc Res. 2021 Feb 22;117(3):767-779. doi: 10.1093/cvr/cvaa019. Cardiovasc Res. 2021. PMID: 32173736 Free PMC article.
Two single-nucleotide variants (SNVs) on the Myotubularin-related protein 4 (MTMR4) gene, an interactor of Nedd4L, were identified by whole-exome sequencing as potential contributors to decreased Nedd4L activity. Correction of these SNVs by CRISPR/Cas9 unmasked the LQTS ph …
Two single-nucleotide variants (SNVs) on the Myotubularin-related protein 4 (MTMR4) gene, an interactor of Nedd4L, were identified by …
MTMR4, a phosphoinositide-specific 3'-phosphatase, regulates TFEB activity and the endocytic and autophagic pathways.
Pham HQ, Yoshioka K, Mohri H, Nakata H, Aki S, Ishimaru K, Takuwa N, Takuwa Y. Pham HQ, et al. Genes Cells. 2018 Jul 2. doi: 10.1111/gtc.12609. Online ahead of print. Genes Cells. 2018. PMID: 29962048 Free article.
MTMR4 was localized mainly in late endosomes and autophagosomes. MTMR4 knockdown markedly suppressed the motility, fusion, and fission of PI(3)P-enriched structures, resulting in decreases in late endosomes, autophagosomes, and lysosomes, and enlargement of PI(3)P-e …
MTMR4 was localized mainly in late endosomes and autophagosomes. MTMR4 knockdown markedly suppressed the motility, fusion, and …
MTMR4 attenuates transforming growth factor beta (TGFbeta) signaling by dephosphorylating R-Smads in endosomes.
Yu J, Pan L, Qin X, Chen H, Xu Y, Chen Y, Tang H. Yu J, et al. J Biol Chem. 2010 Mar 12;285(11):8454-62. doi: 10.1074/jbc.M109.075036. Epub 2010 Jan 8. J Biol Chem. 2010. PMID: 20061380 Free PMC article.
Further analysis showed that overexpression of MTMR4 resulted in the sequestration of activated Smad3 in the early endosomes, thus reducing its nuclear translocation. However, both point mutations at the conserved catalytic site of the phosphatase (MTMR4-C407S) and …
Further analysis showed that overexpression of MTMR4 resulted in the sequestration of activated Smad3 in the early endosomes, thus re …
PtdIns3P phosphatases MTMR3 and MTMR4 negatively regulate innate immune responses to DNA through modulating STING trafficking.
Dewi Pamungkas Putri D, Kawasaki T, Murase M, Sueyoshi T, Deguchi T, Ori D, Suetsugu S, Kawai T. Dewi Pamungkas Putri D, et al. J Biol Chem. 2019 May 24;294(21):8412-8423. doi: 10.1074/jbc.RA118.005731. Epub 2019 Apr 3. J Biol Chem. 2019. PMID: 30944173 Free PMC article.
Here we found that STING trafficking is regulated by myotubularin-related protein (MTMR) 3 and MTMR4, members of protein tyrosine phosphatases that dephosphorylate 3' position in phosphatidylinositol (PtdIns) and generate PtdIns5P from PtdIns3,5P(2) and PtdIns from PtdIns3 …
Here we found that STING trafficking is regulated by myotubularin-related protein (MTMR) 3 and MTMR4, members of protein tyrosine pho …
The myotubularin phosphatase MTMR4 regulates sorting from early endosomes.
Naughtin MJ, Sheffield DA, Rahman P, Hughes WE, Gurung R, Stow JL, Nandurkar HH, Dyson JM, Mitchell CA. Naughtin MJ, et al. J Cell Sci. 2010 Sep 15;123(Pt 18):3071-83. doi: 10.1242/jcs.060103. Epub 2010 Aug 24. J Cell Sci. 2010. PMID: 20736309
In cells with MTMR4 knockdown, or following expression of the catalytically inactive MTMR4, MTMR4(C407A), the number of PtdIns(3)P-decorated endosomes significantly increased. ...MTMR4 regulated the subcellular distribution of Rab11 and, in cells with …
In cells with MTMR4 knockdown, or following expression of the catalytically inactive MTMR4, MTMR4(C407A), the number of …
Myotubularin-related protein 4 (MTMR4) attenuates BMP/Dpp signaling by dephosphorylation of Smad proteins.
Yu J, He X, Chen YG, Hao Y, Yang S, Wang L, Pan L, Tang H. Yu J, et al. J Biol Chem. 2013 Jan 4;288(1):79-88. doi: 10.1074/jbc.M112.413856. Epub 2012 Nov 13. J Biol Chem. 2013. PMID: 23150675 Free PMC article.
Therefore, transcriptional activation by BMPs was tightly controlled by the expression level and the intrinsic phosphatase activity of MTMR4. More profoundly, ectopic expression of MTMR4 or its Drosophila homolog CG3632 genetically interacted with BMP/Dpp signaling …
Therefore, transcriptional activation by BMPs was tightly controlled by the expression level and the intrinsic phosphatase activity of MT …
RAF1 kinase contributes to autophagic lysosome reformation.
Toifl S, Didusch S, Ehrenreiter K, Desideri E, Dorard C, Baccarini M. Toifl S, et al. Cell Rep. 2025 Apr 22;44(4):115490. doi: 10.1016/j.celrep.2025.115490. Epub 2025 Apr 3. Cell Rep. 2025. PMID: 40184255 Free article.
Two of these, SPG11 and the lipid phosphatase MTMR4, are RAF1 substrates. RAF1 ablation causes the appearance of enlarged autolysosomes and alters the phosphoinositide composition of autolysosomes. RAF1 and MTMR4 colocalize on autolysosomes, and overexpression of a …
Two of these, SPG11 and the lipid phosphatase MTMR4, are RAF1 substrates. RAF1 ablation causes the appearance of enlarged autolysosom …
The inositol phosphatase MTMR4 is a novel target of the ubiquitin ligase Nedd4.
Plant PJ, Correa J, Goldenberg N, Bain J, Batt J. Plant PJ, et al. Biochem J. 2009 Apr 1;419(1):57-63. doi: 10.1042/BJ20081866. Biochem J. 2009. PMID: 19125695 Free PMC article.
The inositol phosphatase, MTMR4 (myotubularin-related protein 4), was identified as a novel interactor of the ubiquitin ligase Nedd4 (neural-precursor-cell-expressed developmentally down-regulated 4). hMTMR4 (human MTMR4) and Nedd4 co-immunoprecipitated and co-local …
The inositol phosphatase, MTMR4 (myotubularin-related protein 4), was identified as a novel interactor of the ubiquitin ligase Nedd4 …
32 results