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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1965 2
1966 4
1967 2
1971 1
1972 1
1973 3
1975 4
1976 2
1977 2
1979 1
1980 3
1981 3
1982 6
1983 4
1984 1
1985 2
1986 2
1987 1
1989 2
1990 1
1992 2
1996 2
1997 1
1998 1
1999 2
2001 2
2002 2
2003 6
2004 4
2005 2
2006 2
2007 2
2008 1
2009 6
2010 2
2011 1
2012 1
2013 1
2014 1
2021 0
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84 results
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Page 1
Apremilast, a cAMP phosphodiesterase-4 inhibitor, demonstrates anti-inflammatory activity in vitro and in a model of psoriasis.
Schafer PH, Parton A, Gandhi AK, Capone L, Adams M, Wu L, Bartlett JB, Loveland MA, Gilhar A, Cheung YF, Baillie GS, Houslay MD, Man HW, Muller GW, Stirling DI. Schafer PH, et al. Among authors: muller gw. Br J Pharmacol. 2010 Feb;159(4):842-55. doi: 10.1111/j.1476-5381.2009.00559.x. Epub 2009 Dec 24. Br J Pharmacol. 2010. PMID: 20050849 Free PMC article.
Alpha-fluoro-substituted thalidomide analogues.
Man HW, Corral LG, Stirling DI, Muller GW. Man HW, et al. Among authors: muller gw. Bioorg Med Chem Lett. 2003 Oct 20;13(20):3415-7. doi: 10.1016/s0960-894x(03)00778-9. Bioorg Med Chem Lett. 2003. PMID: 14505639
Isosteric analogs of lenalidomide and pomalidomide: synthesis and biological activity.
Ruchelman AL, Man HW, Zhang W, Chen R, Capone L, Kang J, Parton A, Corral L, Schafer PH, Babusis D, Moghaddam MF, Tang Y, Shirley MA, Muller GW. Ruchelman AL, et al. Among authors: muller gw. Bioorg Med Chem Lett. 2013 Jan 1;23(1):360-5. doi: 10.1016/j.bmcl.2012.10.071. Epub 2012 Oct 27. Bioorg Med Chem Lett. 2013. PMID: 23168019
Thalidomide analogs and PDE4 inhibition.
Muller GW, Shire MG, Wong LM, Corral LG, Patterson RT, Chen Y, Stirling DI. Muller GW, et al. Bioorg Med Chem Lett. 1998 Oct 6;8(19):2669-74. doi: 10.1016/s0960-894x(98)00475-2. Bioorg Med Chem Lett. 1998. PMID: 9873600
Discovery of (S)-N-[2-[1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl] acetamide (apremilast), a potent and orally active phosphodiesterase 4 and tumor necrosis factor-alpha inhibitor.
Man HW, Schafer P, Wong LM, Patterson RT, Corral LG, Raymon H, Blease K, Leisten J, Shirley MA, Tang Y, Babusis DM, Chen R, Stirling D, Muller GW. Man HW, et al. Among authors: muller gw. J Med Chem. 2009 Mar 26;52(6):1522-4. doi: 10.1021/jm900210d. J Med Chem. 2009. PMID: 19256507
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