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Year Number of Results
1999 1
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2009 1
2011 4
2012 3
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2014 5
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2019 11
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2021 20
2022 18
2023 16

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99 results

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Page 1
Vasorin deficiency leads to cardiac hypertrophy by targeting MYL7 in young mice.
Sun J, Guo X, Yu P, Liang J, Mo Z, Zhang M, Yang L, Huang X, Hu B, Liu J, Ouyang Y, He M. Sun J, et al. J Cell Mol Med. 2022 Jan;26(1):88-98. doi: 10.1111/jcmm.17034. Epub 2021 Dec 2. J Cell Mol Med. 2022. PMID: 34854218 Free PMC article.
The aim of this research was to ascertain whether VASN induces pathological cardiac hypertrophy by targeting myosin light chain 7 (MYL7). VASN(-/-) mice were produced by CRISPR/Cas9 technology and inbreeding. ...Our results revealed a pathological phenomenon in which VASN …
The aim of this research was to ascertain whether VASN induces pathological cardiac hypertrophy by targeting myosin light chain 7 (MYL7 …
Development of Tg(UAS:SEC-Hsa.ANXA5-YFP,myl7:RFP); Casper(roy-/-,nacre-/-) Transparent Transgenic In Vivo Zebrafish Model to Study the Cardiomyocyte Function.
Rajpurohit SK, Gopal A, Mon MY, Patel NG, Arora V. Rajpurohit SK, et al. Cells. 2021 Aug 2;10(8):1963. doi: 10.3390/cells10081963. Cells. 2021. PMID: 34440732 Free PMC article.
The Casper(roy(-/-),nacre(-/-)) transgenic progenies developed through cross-breeding with the transgenic strain of Tg(UAS:SEC-Hsa.ANXA5-YFP,myl7:RFP). Confocal and fluorescent microscopy were being used to obtain accurate, precise imaging and to determine fluorescent prot …
The Casper(roy(-/-),nacre(-/-)) transgenic progenies developed through cross-breeding with the transgenic strain of Tg(UAS:SEC-Hsa.ANXA5-YFP …
Generation of a dual edited human induced pluripotent stem cell Myl7-GFP reporter line with inducible CRISPRi/dCas9.
Metzl-Raz E, Bharucha N, Arthur Ataam J, Gavidia AA, Greenleaf WJ, Karakikes I. Metzl-Raz E, et al. Stem Cell Res. 2022 May;61:102754. doi: 10.1016/j.scr.2022.102754. Epub 2022 Mar 18. Stem Cell Res. 2022. PMID: 35325819 Free PMC article.
We targeted a doxycycline-inducible dCas9-KRAB-mCherry cassette into the AAVS1 locus in an MYL7-mGFP reporter iPSC line. A clone with bi-allelic integration displayed minimally leaky CRISPRi activity and strong expression upon addition of doxycycline in iPSCs, iPSC-derived …
We targeted a doxycycline-inducible dCas9-KRAB-mCherry cassette into the AAVS1 locus in an MYL7-mGFP reporter iPSC line. A clone with …
Early calcium and cardiac contraction defects in a model of phospholamban R9C mutation in zebrafish.
Vicente M, Salgado-Almario J, Valiente-Gabioud AA, Collins MM, Vincent P, Domingo B, Llopis J. Vicente M, et al. J Mol Cell Cardiol. 2022 Dec;173:127-140. doi: 10.1016/j.yjmcc.2022.10.005. Epub 2022 Oct 20. J Mol Cell Cardiol. 2022. PMID: 36273660 Free article.
We generated transgenic zebrafish lines expressing phospholamban wild-type (Tg(myl7:plnb(wt))) and phospholamban R9C (Tg(myl7:plnb(R9C))) in the heart of zebrafish. To measure calcium and cardiac contraction in 3 and 9 dpf larvae, Tg(myl7:plnb(wt)) and Tg( …
We generated transgenic zebrafish lines expressing phospholamban wild-type (Tg(myl7:plnb(wt))) and phospholamban R9C (Tg(myl7: …
Resveratrol ameliorates penconazole-induced cardiotoxicity by inhibition of oxidative stress and apoptosis in zebrafish larvae.
Jiang X, Wang J, Liu J, Zhu H, Hu J, Sun X, Zhou W. Jiang X, et al. Ecotoxicol Environ Saf. 2023 May;256:114865. doi: 10.1016/j.ecoenv.2023.114865. Epub 2023 Apr 3. Ecotoxicol Environ Saf. 2023. PMID: 37018857 Free article.
PEN induced pericardial edema and abnormal cardiac structure in myl7:egfp transgenic zebrafish, as well as downregulation of cardiac development related genes (nkx2.5, tbx2.5, gata4, noto, and vmhc). ...
PEN induced pericardial edema and abnormal cardiac structure in myl7:egfp transgenic zebrafish, as well as downregulation of cardiac …
Isoflucypram cardiovascular toxicity in zebrafish (Danio rerio).
Chen X, Li W. Chen X, et al. Sci Total Environ. 2021 Sep 15;787:147529. doi: 10.1016/j.scitotenv.2021.147529. Epub 2021 May 6. Sci Total Environ. 2021. PMID: 33991914
The expression levels of cardiac-specific genes (nkx2.5, myh7, myl7, and myh6) and erythropoiesis-related genes (gata1a, hbbe1, hbbe2, and alas2) were disrupted after isoflucypram exposure. ...
The expression levels of cardiac-specific genes (nkx2.5, myh7, myl7, and myh6) and erythropoiesis-related genes (gata1a, hbbe1, hbbe2 …
Top-down proteomics of myosin light chain isoforms define chamber-specific expression in the human heart.
Bayne EF, Rossler KJ, Gregorich ZR, Aballo TJ, Roberts DS, Chapman EA, Guo W, Palecek SP, Ralphe JC, Kamp TJ, Ge Y. Bayne EF, et al. J Mol Cell Cardiol. 2023 Aug;181:89-97. doi: 10.1016/j.yjmcc.2023.06.003. Epub 2023 Jun 14. J Mol Cell Cardiol. 2023. PMID: 37327991
For the first time, a putative deamidation post-translation modification (PTM) located on MLC-2v in atrial tissue was localized to amino acid N13. MLC-1v (MYL3) and MLC-2a (MYL7) were the only MLC isoforms exhibiting chamber-restricted expression patterns across all donor …
For the first time, a putative deamidation post-translation modification (PTM) located on MLC-2v in atrial tissue was localized to amino aci …
Zebrafish heart regenerates after chemoptogenetic cardiomyocyte depletion.
Missinato MA, Zuppo DA, Watkins SC, Bruchez MP, Tsang M. Missinato MA, et al. Dev Dyn. 2021 Jul;250(7):986-1000. doi: 10.1002/dvdy.305. Epub 2021 Feb 8. Dev Dyn. 2021. PMID: 33501711 Free PMC article.
Here, we characterize cardiac regeneration from cardiomyocyte chemoptogenetic ablation caused by localized near-infrared excited photosensitizer-mediated reactive oxygen species (ROS) generation. RESULTS: Exposure of transgenic adult zebrafish, Tg(myl7:fapdl5-cerulean), to …
Here, we characterize cardiac regeneration from cardiomyocyte chemoptogenetic ablation caused by localized near-infrared excited photosensit …
Paroxetine induced larva zebrafish cardiotoxicity through inflammation response.
Zhu Y, Song F, Gu J, Wu L, Wu W, Ji G. Zhu Y, et al. Ecotoxicol Environ Saf. 2023 Jul 15;260:115096. doi: 10.1016/j.ecoenv.2023.115096. Epub 2023 Jun 1. Ecotoxicol Environ Saf. 2023. PMID: 37269614 Free article.
In this study, zebrafish embryos were exposed to 1.0, 5.0, 10 and 20 mg/L of PRX from 4 to 120-hour-post-fertilization (hpf), and it showed that PRX exposure caused adverse effects in zebrafish embryos, including decreased body length, blood flow velocity, cardiac frequency, card …
In this study, zebrafish embryos were exposed to 1.0, 5.0, 10 and 20 mg/L of PRX from 4 to 120-hour-post-fertilization (hpf), and it showed …
Cardiotoxicity of Zebrafish Induced by 6-Benzylaminopurine Exposure and Its Mechanism.
Yang M, Luan J, Xu Y, Zhao C, Sun M, Feng X. Yang M, et al. Int J Mol Sci. 2022 Jul 29;23(15):8438. doi: 10.3390/ijms23158438. Int J Mol Sci. 2022. PMID: 35955574 Free PMC article.
We found that 6-BA affected larval cardiogenesis, inducing defective expression of key genes for cardiac development (myl7, vmhc, and myh6) and AVC differentiation (bmp4, tbx2b, and notch1b), ultimately leading to weakened cardiac function (heart rate, diastolic speed, sys …
We found that 6-BA affected larval cardiogenesis, inducing defective expression of key genes for cardiac development (myl7, vmhc, and …
99 results