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188 results

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Page 1
MYO10 regulates genome stability and cancer inflammation through mediating mitosis.
Mayca Pozo F, Geng X, Miyagi M, Amin AL, Huang AY, Zhang Y. Mayca Pozo F, et al. Cell Rep. 2023 May 30;42(5):112531. doi: 10.1016/j.celrep.2023.112531. Epub 2023 May 17. Cell Rep. 2023. PMID: 37200188 Free PMC article.
Previous research revealed an unexpected layer of regulation of genomic instability by a cytoplasmic protein MYO10; however, the underlying mechanism remained unclear. Here, we report a protein stability-mediated mitotic regulation of MYO10 in controlling genome sta …
Previous research revealed an unexpected layer of regulation of genomic instability by a cytoplasmic protein MYO10; however, the unde …
MYO10-filopodia support basement membranes at pre-invasive tumor boundaries.
Peuhu E, Jacquemet G, Scheele CLGJ, Isomursu A, Laisne MC, Koskinen LM, Paatero I, Thol K, Georgiadou M, Guzmán C, Koskinen S, Laiho A, Elo LL, Boström P, Hartiala P, van Rheenen J, Ivaska J. Peuhu E, et al. Dev Cell. 2022 Oct 24;57(20):2350-2364.e7. doi: 10.1016/j.devcel.2022.09.016. Dev Cell. 2022. PMID: 36283390 Free article.
We identify elevated MYO10 expression in human DCIS and IBC, and this suggests links with disease progression. ...In addition, cancer spheroids are dependent on MYO10-filopodia to generate a near-continuous extracellular matrix boundary. Thus, MYO10 is protec …
We identify elevated MYO10 expression in human DCIS and IBC, and this suggests links with disease progression. ...In addition, cancer …
MYO10 promotes transzonal projection-dependent germ line-somatic contact during mammalian folliculogenesis.
Granados-Aparici S, Volodarsky-Perel A, Yang Q, Anam S, Tulandi T, Buckett W, Son WY, Younes G, Chung JT, Jin S, Terret ME, Clarke HJ. Granados-Aparici S, et al. Biol Reprod. 2022 Aug 9;107(2):474-487. doi: 10.1093/biolre/ioac078. Biol Reprod. 2022. PMID: 35470858 Free PMC article.
In both mouse and human, the number of MYO10 foci increases as oocytes grow, corresponding to the increase in the number of actin-TZPs. RNAi-mediated depletion of MYO10 in cultured mouse granulosa cell-oocyte complexes is associated with a 52% reduction in the numbe …
In both mouse and human, the number of MYO10 foci increases as oocytes grow, corresponding to the increase in the number of actin-TZP …
MYO10 drives genomic instability and inflammation in cancer.
Mayca Pozo F, Geng X, Tamagno I, Jackson MW, Heimsath EG, Hammer JA, Cheney RE, Zhang Y. Mayca Pozo F, et al. Sci Adv. 2021 Sep 17;7(38):eabg6908. doi: 10.1126/sciadv.abg6908. Epub 2021 Sep 15. Sci Adv. 2021. PMID: 34524844 Free PMC article.
Here, we report that the cytoplasmic unconventional Myosin X (MYO10) regulates genome stability, through which it mediates inflammation in cancer. MYO10 is an unstable protein that undergoes ubiquitin-conjugating enzyme H7 (UbcH7)/beta-transducin repeat containing p …
Here, we report that the cytoplasmic unconventional Myosin X (MYO10) regulates genome stability, through which it mediates inflammati …
MYO10 contributes to the malignant phenotypes of colorectal cancer via RACK1 by activating integrin/Src/FAK signaling.
Ou H, Wang L, Xi Z, Shen H, Jiang Y, Zhou F, Liu Y, Zhou Y. Ou H, et al. Cancer Sci. 2022 Nov;113(11):3838-3851. doi: 10.1111/cas.15519. Epub 2022 Aug 26. Cancer Sci. 2022. PMID: 35912545 Free PMC article.
Here, we found that MYO10 was highly expressed in CRC tumor tissues, especially in liver metastasis tissues. MYO10 knockout reduced CRC cell proliferation, invasion, and migration in vitro and CRC metastasis in vivo. ...
Here, we found that MYO10 was highly expressed in CRC tumor tissues, especially in liver metastasis tissues. MYO10 knockout re …
Myo10 tail is crucial for promoting long filopodia.
Chen X, Arciola JM, Lee YI, Wong PHP, Yin H, Tao Q, Jin Y, Qin X, Sweeney HL, Park H. Chen X, et al. J Biol Chem. 2024 Jan;300(1):105523. doi: 10.1016/j.jbc.2023.105523. Epub 2023 Dec 2. J Biol Chem. 2024. PMID: 38043799 Free PMC article.
However, the roles of the multifunctional tail domain of Myo10 in filopodial formation and elongation remain elusive. Herein, we generated several constructs of Myo10-full-length Myo10, Myo10 with a truncated tail (Myo10 HMM), and Myo10 c …
However, the roles of the multifunctional tail domain of Myo10 in filopodial formation and elongation remain elusive. Herein, we gene …
Myosin X.
Tokuo H. Tokuo H. Adv Exp Med Biol. 2020;1239:391-403. doi: 10.1007/978-3-030-38062-5_17. Adv Exp Med Biol. 2020. PMID: 32451868 Review.
Myosin X (Myo10), an actin-based molecular motor, induces filopodia formation and controls cell migration in vitro. ...Recently, the availability of Myo10-knockout (Myo10KO) mice has allowed for tremendous progress toward understanding the biological function of …
Myosin X (Myo10), an actin-based molecular motor, induces filopodia formation and controls cell migration in vitro. ...Recently, the …
Myo10 is required for neurogenic cell adhesion and migration.
Yu H, Lai M, Guo Y, Yuan L, Lan Y, Wang X, Zhu X. Yu H, et al. In Vitro Cell Dev Biol Anim. 2015 Apr;51(4):400-7. doi: 10.1007/s11626-014-9845-z. Epub 2014 Dec 10. In Vitro Cell Dev Biol Anim. 2015. PMID: 25491426
In the wound healing assay, with the Golgi complex staining to display cell polarity, Myo10 knockdown cells were randomly oriented compared to the control. Furthermore, suppressing the expression of Myo10 decreased the ability of cell-matrix adhesion. N-cadherin, a …
In the wound healing assay, with the Golgi complex staining to display cell polarity, Myo10 knockdown cells were randomly oriented co …
Elevated MYO10 Predicts Poor Prognosis and its Deletion Hampers Proliferation and Migration Potentials of Cells Through Rewiring PI3K/Akt Signaling in Cervical Cancer.
He JH, Chen JG, Zhang B, Chen J, You KL, Hu JM, Xu JW, Chen L. He JH, et al. Technol Cancer Res Treat. 2020 Jan-Dec;19:1533033820936773. doi: 10.1177/1533033820936773. Technol Cancer Res Treat. 2020. PMID: 32618228 Free PMC article.
MYO10, recognized as an important regulator of cytoskeleton remodeling, has been reported to be associated with tumorigenesis. ...MYO10 was upregulated in cervical cancer tissues and cells when compared to normal controls, and survival analysis showed patients with …
MYO10, recognized as an important regulator of cytoskeleton remodeling, has been reported to be associated with tumorigenesis. ... …
Myosin-X and disease.
Courson DS, Cheney RE. Courson DS, et al. Exp Cell Res. 2015 May 15;334(1):10-5. doi: 10.1016/j.yexcr.2015.03.014. Epub 2015 Mar 27. Exp Cell Res. 2015. PMID: 25819274 Free PMC article. Review.
Myosin-X (Myo10) is a motor protein best known for its role in filopodia formation. New research implicates Myo10 in a number of disease states including cancer metastasis and pathogen infection. This review focuses on these developments with emphasis on the emergin …
Myosin-X (Myo10) is a motor protein best known for its role in filopodia formation. New research implicates Myo10 in a number …
188 results