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Page 1
Myt1 kinase inhibitors - Insight into structural features, offering potential frameworks.
Tomović Pavlović K, Kocić G, Šmelcerović A. Tomović Pavlović K, et al. Chem Biol Interact. 2024 Mar 1;391:110901. doi: 10.1016/j.cbi.2024.110901. Epub 2024 Feb 6. Chem Biol Interact. 2024. PMID: 38331334 Review.
Many cancer cell lines exhibit weak G1 checkpoint mechanisms relying significantly more on the G2 checkpoint than do healthy cells. Inhibition of Myt1 kinase (PKMYT1), a forgotten member of the Wee family, cyclin-dependent kinase 1 (Cdk1) inhibitory kinase, target for G2 c …
Many cancer cell lines exhibit weak G1 checkpoint mechanisms relying significantly more on the G2 checkpoint than do healthy cells. Inhibiti …
Targeting replication stress in cancer therapy.
da Costa AABA, Chowdhury D, Shapiro GI, D'Andrea AD, Konstantinopoulos PA. da Costa AABA, et al. Nat Rev Drug Discov. 2023 Jan;22(1):38-58. doi: 10.1038/s41573-022-00558-5. Epub 2022 Oct 6. Nat Rev Drug Discov. 2023. PMID: 36202931 Free PMC article. Review.
This vulnerability can be therapeutically targeted by inhibiting kinases that coordinate the DNA damage response with cell cycle control, including ATR, CHK1, WEE1 and MYT1 checkpoint kinases. In addition, inhibiting the DNA damage response releases DNA fragments into the …
This vulnerability can be therapeutically targeted by inhibiting kinases that coordinate the DNA damage response with cell cycle control, in …
MYT1 attenuates neuroblastoma cell differentiation by interacting with the LSD1/CoREST complex.
Chen K, Cai Y, Cheng C, Zhang J, Lv F, Xu G, Duan P, Wu Y, Wu Z. Chen K, et al. Oncogene. 2020 May;39(21):4212-4226. doi: 10.1038/s41388-020-1268-6. Epub 2020 Apr 6. Oncogene. 2020. PMID: 32251364
Integrated omics data indicated that many genes involved in neuro-differentiation were regulated by MYT1. Interestingly, many of these genes are targets of the REST complex; therefore, we further identified the physical interaction of MYT1 with LSD1/CoREST. Depletio …
Integrated omics data indicated that many genes involved in neuro-differentiation were regulated by MYT1. Interestingly, many of thes …
Myt1: a Wee1-type kinase that phosphorylates Cdc2 on residue Thr14.
Fattaey A, Booher RN. Fattaey A, et al. Prog Cell Cycle Res. 1997;3:233-40. doi: 10.1007/978-1-4615-5371-7_18. Prog Cell Cycle Res. 1997. PMID: 9552418 Review.
The kinases responsible for these two phosphorylation events include the Myt1 and Wee1 kinases, which phosphorylate Cdc2 on Thr14 and Tyr15, respectively. In this discussion, we summarise our current knowledge of the Myt1 kinase and its regulation of Cdc2 kinase act …
The kinases responsible for these two phosphorylation events include the Myt1 and Wee1 kinases, which phosphorylate Cdc2 on Thr14 and …
Myt1 overexpression mediates resistance to cell cycle and DNA damage checkpoint kinase inhibitors.
Sokhi S, Lewis CW, Bukhari AB, Hadfield J, Xiao EJ, Fung J, Yoon YJ, Hsu WH, Gamper AM, Chan GK. Sokhi S, et al. Front Cell Dev Biol. 2023 Nov 2;11:1270542. doi: 10.3389/fcell.2023.1270542. eCollection 2023. Front Cell Dev Biol. 2023. PMID: 38020882 Free PMC article.
Our lab recently identified Myt1 as a predictive biomarker of acquired resistance to the Wee1 kinase inhibitor, Adavosertib. ...We demonstrate that Myt1 confers resistance by compensating Cdk1 inhibition in the presence of these different kinase inhibitors. ...
Our lab recently identified Myt1 as a predictive biomarker of acquired resistance to the Wee1 kinase inhibitor, Adavosertib. ...We de …
Myt1 Kinase Couples Mitotic Cell Cycle Exit with Differentiation in Drosophila.
Willms RJ, Zeng J, Campbell SD. Willms RJ, et al. Cell Rep. 2020 Nov 17;33(7):108400. doi: 10.1016/j.celrep.2020.108400. Cell Rep. 2020. PMID: 33207203 Free article.
Here, we use myt1-null mutants and cell-specific RNA interference to investigate Myt1 function in stem cells and enteroblast progenitors. Myt1 depletion alters cell cycle kinetics and promotes ectopic stem cell and enteroblast mitoses at the expense of entero …
Here, we use myt1-null mutants and cell-specific RNA interference to investigate Myt1 function in stem cells and enteroblast p …
Regulation of Myt1 kinase activity via its N-terminal region in Xenopus meiosis and mitosis.
Aiba Y, Kim J, Imamura A, Okumoto K, Nakajo N. Aiba Y, et al. Cells Dev. 2022 Mar;169:203754. doi: 10.1016/j.cdev.2021.203754. Epub 2021 Oct 22. Cells Dev. 2022. PMID: 34695617 Free article.
Furthermore, multiple phosphorylations by Cdk1 at the Myt1 N-terminal region were found to be involved in the negative regulation of Myt1. In particular, phosphorylations at Thr11 and Thr16 of Myt1, which are adjacent to the PAYF motif, were found to be impor …
Furthermore, multiple phosphorylations by Cdk1 at the Myt1 N-terminal region were found to be involved in the negative regulation of …
MYT1 role in the microtia-craniofacial microsomia spectrum.
Luquetti DV, Heike CL, Zarante I, Timms AE, Gustafson J, Pachajoa H, Porras-Hurtado GL, Ayala-Ramirez P, Duenas-Roque MM, Jimenez N, Ibanez LM, Hurtado-Villa P. Luquetti DV, et al. Mol Genet Genomic Med. 2020 Oct;8(10):e1401. doi: 10.1002/mgg3.1401. Epub 2020 Sep 1. Mol Genet Genomic Med. 2020. PMID: 32871052 Free PMC article.
The etiology of CFM is largely unknown. The MYT1 gene has been reported as a candidate based in mutations found in three unrelated individuals. ...We present two individuals with CFM that have rare variants in MYT1 contributing to better understand the genotype and …
The etiology of CFM is largely unknown. The MYT1 gene has been reported as a candidate based in mutations found in three unrelated in …
Novel MYT1 variants expose the complexity of oculo-auriculo-vertebral spectrum genetic mechanisms.
Zamariolli M, Burssed B, Moysés-Oliveira M, Colovati M, Bellucco FTDS, Dos Santos LC, Alvarez Perez AB, Bragagnolo S, Melaragno MI. Zamariolli M, et al. Am J Med Genet A. 2021 Jul;185(7):2056-2064. doi: 10.1002/ajmg.a.62217. Epub 2021 Apr 21. Am J Med Genet A. 2021. PMID: 33880880
The spectrum presents with heterogeneous clinical features and complex etiology with genetic factors not yet completely understood. To date, MYT1 is the most important gene unambiguously associated with the spectrum and with functional data confirmation. ...All five patien …
The spectrum presents with heterogeneous clinical features and complex etiology with genetic factors not yet completely understood. To date, …
374 results