HIF-1alpha and HIF-2alpha play a central role in stretch-induced but not shear-stress-induced angiogenesis in rat skeletal muscle.
Milkiewicz M, Doyle JL, Fudalewski T, Ispanovic E, Aghasi M, Haas TL.
Milkiewicz M, et al.
J Physiol. 2007 Sep 1;583(Pt 2):753-66. doi: 10.1113/jphysiol.2007.136325. Epub 2007 Jul 12.
J Physiol. 2007.
PMID: 17627993
Free PMC article.
Conversely, HIF-1alpha and HIF-2alpha mRNA were reduced significantly, and HIF-alpha proteins were undetectable, after 24 h exposure to elevated shear stress (16 dyn cm(-2) (16 x10(-5) N cm(-2)). Given the disparate regulation of HIFs in response to these mechanical stimul …
Conversely, HIF-1alpha and HIF-2alpha mRNA were reduced significantly, and HIF-alpha proteins were undetectable, after 24 h exposure to elev …