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Page 1
Indole-carbohydrazide linked phenoxy-1,2,3-triazole-N-phenylacetamide derivatives as potent alpha-glucosidase inhibitors: design, synthesis, in vitro alpha-glucosidase inhibition, and computational studies.
Emadi M, Mosavizadeh-Marvest F, Asadipour A, Pourshojaei Y, Hosseini S, Mojtabavi S, Faramarzi MA, Larijani B, Mohammadi-Khanaposhtani M, Mahdavi M. Emadi M, et al. BMC Chem. 2023 Jun 15;17(1):56. doi: 10.1186/s13065-023-00971-w. BMC Chem. 2023. PMID: 37316931 Free PMC article.
BACKGROUND: A new series of indole-carbohydrazide-phenoxy-1,2,3-triazole-N-phenylacetamide hybrids 11a-o was designed based on molecular hybridization of the active pharmacophores of the potent alpha-glucosidase inhibitors. ...Representatively, (E)-2-(4-((4-((2-(1H-indole- …
BACKGROUND: A new series of indole-carbohydrazide-phenoxy-1,2,3-triazole-N-phenylacetamide hybrids 11a-o was designed based on molecu …
Design, synthesis, in vitro anti-alpha-glucosidase evaluations, and computational studies of new phthalimide-phenoxy-1,2,3-triazole-N-phenyl (or benzyl) acetamides as potential anti-diabetic agents.
Emadi M, Halimi M, Moazzam A, Hosseini S, Mojtabavi S, Faramarzi MA, Ghadimi R, Moghadamnia AA, Nasli-Esfahani E, Mohammadi-Khanaposhtani M, Mahdavi M. Emadi M, et al. Sci Rep. 2023 Jun 20;13(1):10030. doi: 10.1038/s41598-023-36890-y. Sci Rep. 2023. PMID: 37340010 Free PMC article.
A new series of phthalimide-phenoxy-1,2,3-triazole-N-phenyl (or benzyl) acetamides 11a-n were designed based on the reported potent alpha-glucosidase inhibitors. ...
A new series of phthalimide-phenoxy-1,2,3-triazole-N-phenyl (or benzyl) acetamides 11a-n were designed based on the reported p …
Fabrication of a novel electrochemical biosensor based on a molecular imprinted polymer-aptamer hybrid receptor for lysozyme determination.
Beiki T, Najafpour-Darzi G, Mohammadi M, Shakeri M, Boukherroub R. Beiki T, et al. Anal Bioanal Chem. 2023 Feb;415(5):899-911. doi: 10.1007/s00216-022-04487-5. Epub 2022 Dec 22. Anal Bioanal Chem. 2023. PMID: 36544030
First, a glassy carbon electrode (GCE) was modified with a nanocomposite consisting of multi-wall carbon nanotubes (MWCNTs), nitrogen-doped carbon quantum dots (N-CQDs), and chitosan. Subsequently, aptamer (Apt)-Lys complex was immobilized on MWCNTs-N-CQDs-chitosan/ …
First, a glassy carbon electrode (GCE) was modified with a nanocomposite consisting of multi-wall carbon nanotubes (MWCNTs), nitrogen-doped …
Molecular dynamics simulation of Doxorubicin loading with N-isopropyl acrylamide carbon nanotube in a drug delivery system.
Maleki R, Afrouzi HH, Hosseini M, Toghraie D, Rostami S. Maleki R, et al. Comput Methods Programs Biomed. 2020 Feb;184:105303. doi: 10.1016/j.cmpb.2019.105303. Epub 2019 Dec 25. Comput Methods Programs Biomed. 2020. PMID: 31901633
Molecular dynamics were applied to investigate the loading of Doxorubicin with thermosensitive N-isopropyl acrylamide Carbon nanotube carrier. METHODS: The results showed that the smaller polymer chain length has more decrease of gyration radius. ...RESULTS: A lower amount …
Molecular dynamics were applied to investigate the loading of Doxorubicin with thermosensitive N-isopropyl acrylamide Carbon nanotube …
Applications of Hyaluronic Acid in Pharmaceuticals, Healthcare and Cosmetics and Its Biosynthesis.
Mousavi S, Dahiya D, Nigam PS, Sionkowska A. Mousavi S, et al. Biotechnol J. 2026 Jan;21(1):e70180. doi: 10.1002/biot.70180. Biotechnol J. 2026. PMID: 41566766 Review.
Hyaluronic acid (HA) is an important homopolysaccharide also known as a natural anionic mucopolysaccharide or glycosaminoglycan formed by the alternate connection of glucuronic acid and N-acetylglucosamine as disaccharide units. For this review, the literature was searched …
Hyaluronic acid (HA) is an important homopolysaccharide also known as a natural anionic mucopolysaccharide or glycosaminoglycan formed by th …
Design, synthesis, and anti-urease evaluations of new sulfonamide-1,2,3-triazole-acetamide derivatives.
Varzaneh SB, Shokouhi Asl AS, Sayahi MH, Taherkhani AM, Talebi M, Dastyafteh N, Safapoor S, Emadi M, Alikhani M, Yazzaf R, Halimi M, Amanlou M, Larijani B, Mohammadi-Khanaposhtani M, Mahdavi M. Varzaneh SB, et al. Sci Rep. 2025 Jul 2;15(1):22565. doi: 10.1038/s41598-025-07553-x. Sci Rep. 2025. PMID: 40595134 Free PMC article.
In this regard, the most potent compounds were N-phenylacetamide derivatives 11b, 11f, and 11 h with 2-methyl, 4-methoxy, and 2-fluoro substituents, respectively. ...
In this regard, the most potent compounds were N-phenylacetamide derivatives 11b, 11f, and 11 h with 2-methyl, 4-methoxy, and 2-fluor …
Recent Updates in Imperative Natural Compounds for Healthy Brain and Nerve Function: A Systematic Review of Implications for Multiple Sclerosis.
Sanadgol N, Zahedani SS, Sharifzadeh M, Khalseh R, Barbari GR, Abdollahi M. Sanadgol N, et al. Curr Drug Targets. 2017;18(13):1499-1517. doi: 10.2174/1389450118666161108124414. Curr Drug Targets. 2017. PMID: 27829351
RESULTS: Studies with vitamins (A, B12, D, H), minerals (selenium and lithium), n-3 PUFAs, lipoic acid, statins, resveratrol, marijuana, EGCG and some probiotics have shown significant helpful effects in MS by preventing or delaying the onset of disease. ...
RESULTS: Studies with vitamins (A, B12, D, H), minerals (selenium and lithium), n-3 PUFAs, lipoic acid, statins, resveratrol, marijua …
A novel gas production bioassay of thiosulfate utilizing denitrifying bacteria (TUDB) for the toxicity assessment of heavy metals contaminated water.
Ashun E, Kang W, Thapa BS, Gurung A, Rahimnejad M, Jang M, Jeon BH, Kim JR, Oh SE. Ashun E, et al. Chemosphere. 2022 Sep;303(Pt 1):134902. doi: 10.1016/j.chemosphere.2022.134902. Epub 2022 May 10. Chemosphere. 2022. PMID: 35561773
Optimization studies indicated that 300 mg NO(3)(-)-N/L, 0.5 mL acclimated culture, and 2100 mg S(2)O(3)(2-)/L were the ideal conditions facilitating the necessary volume of gas production for sensitive data generation. ...
Optimization studies indicated that 300 mg NO(3)(-)-N/L, 0.5 mL acclimated culture, and 2100 mg S(2)O(3)(2-)/L were the ideal conditi …
Development of a Machine Learning-Based Screening Method for Thyroid Nodules Classification by Solving the Imbalance Challenge in Thyroid Nodules Data.
Khodabandelu S, Ghaemian N, Khafri S, Ezoji M, Khaleghi S. Khodabandelu S, et al. J Res Health Sci. 2022 Oct 19;22(3):e00555. doi: 10.34172/jrhs.2022.90. J Res Health Sci. 2022. PMID: 36511373 Free PMC article.
RESULTS: The prevalence of malignant nodules was obtained at 14% (n = 61). In addition, 87% of the patients in this study were women. However, there was no difference in the prevalence of malignancy for gender. ...
RESULTS: The prevalence of malignant nodules was obtained at 14% (n = 61). In addition, 87% of the patients in this study were women. …
37 results