Intestinal Targeting of Ganciclovir Release Employing a Novel HEC-PAA Blended Lyomatrix.
Mabrouk M, Mulla JA, Kumar P, Chejara DR, Badhe RV, Choonara YE, du Toit LC, Pillay V.
Mabrouk M, et al.
AAPS PharmSciTech. 2016 Oct;17(5):1120-30. doi: 10.1208/s12249-015-0442-6. Epub 2015 Nov 9.
AAPS PharmSciTech. 2016.
PMID: 26552400
Kinetic modeling revealed that the GCV-loaded lyomatrix exhibited zero-order release kinetics (n = 1), while the tablets were best described via the Peppas model. Textural analysis highlighted enhanced matrix resilience and rigidity gradient (12.5%, 20 Pa) for the GCV-load …
Kinetic modeling revealed that the GCV-loaded lyomatrix exhibited zero-order release kinetics (n = 1), while the tablets were best de …