Cerebral Whipple's disease as a cause of reversible dementia

T Rossi; R Haghighipour; M Haghighi; S Paolini; O Scarpino

doi:10.1016/j.clineuro.2004.10.014

Cerebral Whipple's disease as a cause of reversible dementia

Clin Neurol Neurosurg. 2005 Apr;107(3):258-61. doi: 10.1016/j.clineuro.2004.10.014.

Authors

T Rossi¹, R Haghighipour, M Haghighi, S Paolini, O Scarpino

Affiliation

¹ Unità Operativa di Neurologia, Ospedale Geriatrico Sestilli, I.N.R.C.A., Ancona, Italy. t.rossi@inrca.it

PMID: 15823686
DOI: 10.1016/j.clineuro.2004.10.014

Abstract

We describe a case of reversible dementia caused by Tropheryma whippelii (TW). Diagnosis was confirmed by a positive polymerase chain reaction for this pathogen both on serum and cerebrospinal fluid. Specific antibiotic therapy resulted in distinct clinical and neuroradiological improvement. Control polymerase chain reaction for T. whippelii on serum and cerebrospinal fluid was negative.

Publication types

Case Reports

MeSH terms

Aged
Anti-Bacterial Agents
Central Nervous System Infections / complications*
Central Nervous System Infections / drug therapy
Dementia / microbiology*
Drug Therapy, Combination / therapeutic use
Female
Humans
Remission Induction
Trimethoprim, Sulfamethoxazole Drug Combination / therapeutic use
Whipple Disease / complications*
Whipple Disease / drug therapy

Substances

Anti-Bacterial Agents
Trimethoprim, Sulfamethoxazole Drug Combination