A Sterically Open Ruthenium-Based Photocage Activated by Red and Far-Red Light for a Wide Range of Drugs.
Husiev Y, Götzfried SK, Hakkennes MLA, Kotova D, Tutein Nolthenius I, van de Griend C, Johns AC, Abyar S, Siegler MA, Kornienko A, Bonnet S.
Husiev Y, et al.
J Am Chem Soc. 2025 Dec 3;147(48):44356-44371. doi: 10.1021/jacs.5c14772. Epub 2025 Nov 18.
J Am Chem Soc. 2025.
PMID: 41252595
Free PMC article.
The new caging moiety is based on the polypyridine pentadentate ligand N(6),N(6")-di(pyridin-2-yl)-[2,2':6',2"-terpyridine]-6,6"-diamine (baptpy), which once coordinated to ruthenium(II) can form the helically chiral [Ru(baptpy)(L)]X(2) prodrugs [6]Cl(2)-[16]Cl(2). …
The new caging moiety is based on the polypyridine pentadentate ligand N(6),N(6")-di(pyridin-2-yl)-[2,2':6',2"-terpyridine]-6, …