Tau induces formation of α-synuclein filaments with distinct molecular conformations.
Hojjatian A, Dasari AKR, Sengupta U, Taylor D, Daneshparvar N, Yeganeh FA, Dillard L, Michael B, Griffin RG, Borgnia MJ, Kayed R, Taylor KA, Lim KH.
Hojjatian A, et al.
Biochem Biophys Res Commun. 2021 May 21;554:145-150. doi: 10.1016/j.bbrc.2021.03.091. Epub 2021 Mar 30.
Biochem Biophys Res Commun. 2021.
PMID: 33798940
Free PMC article.
Our cryo-EM structure of the tau-promoted alpha-synuclein filaments reveals some similarities to one of the previously reported polymorphs of in vitro alpha-synuclein filaments in the core region, while illustrating distinct conformations in the N- and C-terminal regions. …
Our cryo-EM structure of the tau-promoted alpha-synuclein filaments reveals some similarities to one of the previously reported polymorphs o …