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26 results

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Long-Term Feeding Soy Protein Concentrates Protect Against Hepatic Steatosis Independent of Isoflavone Levels.
Li W, Spray B, Børsheim E, Korourian S, Hakkak R. Li W, et al. J Med Food. 2023 Dec;26(12):911-918. doi: 10.1089/jmf.2023.0118. Epub 2023 Nov 15. J Med Food. 2023. PMID: 37971778
The current study extended the dietary treatments to 18 weeks to investigate the long-term effect of LIF and HIF SPC diets. 6-week-old male lean (L, n = 21) and obese (O, n = 21) Zucker rats were fed a casein C diet, LIF and HIF SPC diets for 18 weeks and body weigh …
The current study extended the dietary treatments to 18 weeks to investigate the long-term effect of LIF and HIF SPC diets. 6-week-old male …
Short-Term Metformin Treatment Enriches Bacteroides dorei in an Obese Liver Steatosis Zucker Rat Model.
Robeson MS 2nd, Manna K, Randolph C, Byrum S, Hakkak R. Robeson MS 2nd, et al. Front Microbiol. 2022 Mar 30;13:834776. doi: 10.3389/fmicb.2022.834776. eCollection 2022. Front Microbiol. 2022. PMID: 35432282 Free PMC article.
Here we investigate the effects of short-term metformin treatment on population of gut microbiota profile in an obese rat model. Five week old obese (n = 12) female Zucker rats after 1 week of acclimation, received AIN-93 G diet for 8 weeks and then rats were randomly assi …
Here we investigate the effects of short-term metformin treatment on population of gut microbiota profile in an obese rat model. Five week o …
Feeding soy protein concentrates with low or high isoflavone decreases liver inflammation by reducing lipopolysaccharide translocation.
Li W, Hakkak R. Li W, et al. Front Nutr. 2023 Nov 20;10:1278158. doi: 10.3389/fnut.2023.1278158. eCollection 2023. Front Nutr. 2023. PMID: 38075211 Free PMC article.
The current study investigated the effect of feeding soy protein concentrate (SPC) with high or low isoflavone (HIF or LIF) on liver inflammation and LPS translocation in obese Zucker rats. Six-week-old male lean (L, n = 21) and obese (O, n = 21) Zucker rats were fe …
The current study investigated the effect of feeding soy protein concentrate (SPC) with high or low isoflavone (HIF or LIF) on liver inflamm …
Effects of obesity and 10 weeks metformin treatment on liver steatosis.
Hakkak R, Rose S, Spray B, Kozaczek M, Korourian S. Hakkak R, et al. Biomed Rep. 2021 Jun;14(6):49. doi: 10.3892/br.2021.1425. Epub 2021 Mar 30. Biomed Rep. 2021. PMID: 33859820 Free PMC article.
Thus, in the present study, the effects of 10 weeks metformin treatment on liver steatosis and related serum markers for liver damage was assessed. Lean and obese (n=16 per group) 5-week old female Zucker rats were provided an AIN-93 G diet for 8 weeks to induce NAFLD, and …
Thus, in the present study, the effects of 10 weeks metformin treatment on liver steatosis and related serum markers for liver damage was as …
Hepatic Proteomics Analysis of Nonalcoholic Fatty Liver Disease Obese Rat Model After Short- and Long-Term Soy Protein Isolate Feeding.
Kozaczek M, Kong B, Bottje W, Hakkak R. Kozaczek M, et al. J Med Food. 2022 Mar;25(3):293-302. doi: 10.1089/jmf.2021.0088. Epub 2021 Dec 9. J Med Food. 2022. PMID: 34883038
To identify possible mechanisms involved in the development and progression of nonalcoholic fatty liver disease (NAFLD), we conducted shotgun proteomics analysis on liver of obese Zucker rats fed either casein (CAS) or soy protein isolate (SPI) for 8 and 16 weeks. Rats (7 weeks o …
To identify possible mechanisms involved in the development and progression of nonalcoholic fatty liver disease (NAFLD), we conducted shotgu …
Dietary soy protein reverses obesity-induced liver steatosis and alters fecal microbial composition independent of isoflavone level.
Hakkak R, Korourian S, Li W, Spray B, Twaddle NC, Randolph CE, Børsheim E, Robeson Ii MS. Hakkak R, et al. Front Nutr. 2024 Oct 28;11:1487859. doi: 10.3389/fnut.2024.1487859. eCollection 2024. Front Nutr. 2024. PMID: 39529929 Free PMC article.
METHODS: Six-week-old male obese Zucker rats (n = 26) were fed a casein control diet (CAS) for 8 weeks and 7 rats were randomly selected and sacrificed to confirm liver steatosis. The remaining rats were randomly assigned to receive CAS, SPC-LIF, or SPC-HIF diet (n …
METHODS: Six-week-old male obese Zucker rats (n = 26) were fed a casein control diet (CAS) for 8 weeks and 7 rats were randomly selec …
Diet Containing Soy Protein Concentrate With Low and High Isoflavones for 9 Weeks Protects Against Non-alcoholic Fatty Liver Steatosis Using Obese Zucker Rats.
Hakkak R, Spray B, Børsheim E, Korourian S. Hakkak R, et al. Front Nutr. 2022 Jun 22;9:913571. doi: 10.3389/fnut.2022.913571. eCollection 2022. Front Nutr. 2022. PMID: 35811988 Free PMC article.
The objectives of the present study were to examine the role of isoflavones levels in soy protein concentrate diets on protection against NAFLD in an obese rat model. Forty-two 6-week old lean (L, n = 21) and obese (O, n = 21) Zucker rats were randomly assigned to 1 …
The objectives of the present study were to examine the role of isoflavones levels in soy protein concentrate diets on protection against NA …
Advanced liver steatosis accompanies an increase in hepatic inflammation, colonic, secondary bile acids and Lactobacillaceae/Lachnospiraceae bacteria in C57BL/6 mice fed a high-fat diet.
Zeng H, Larson KJ, Cheng WH, Bukowski MR, Safratowich BD, Liu Z, Hakkak R. Zeng H, et al. J Nutr Biochem. 2020 Apr;78:108336. doi: 10.1016/j.jnutbio.2019.108336. Epub 2020 Jan 8. J Nutr Biochem. 2020. PMID: 32004929
Furthermore, RNA sequencing, qPCR and immunohistological methods found that nicotinamide n-methyltransferase and selenoprotein P, two inflammation-related hepatic genes, were upregulated in the HF group. ...
Furthermore, RNA sequencing, qPCR and immunohistological methods found that nicotinamide n-methyltransferase and selenoprotein P, two …
26 results