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Page 1
The Candida glabrata glycogen branching enzyme structure reveals unique features of branching enzymes of the Saccharomycetaceae phylum.
Conchou L, Martin J, Gonçalves IR, Galisson F, Violot S, Guillière F, Aghajari N, Ballut L. Conchou L, et al. Glycobiology. 2022 Mar 31;32(4):343-355. doi: 10.1093/glycob/cwab110. Glycobiology. 2022. PMID: 34939121
The structures revealed the presence of a domain already observed in Homo sapiens and Oryza sativa BEs that we named alpha-helical N-terminal domain, in addition to the three conserved domains found in BE. We confirmed by phylogenetic analysis that this alpha-helical N …
The structures revealed the presence of a domain already observed in Homo sapiens and Oryza sativa BEs that we named alpha-helical N- …
Structural Basis for the Acceleration of Procollagen Processing by Procollagen C-Proteinase Enhancer-1.
Pulido D, Sharma U, Vadon-Le Goff S, Hussain SA, Cordes S, Mariano N, Bettler E, Moali C, Aghajari N, Hohenester E, Hulmes DJS. Pulido D, et al. Structure. 2018 Oct 2;26(10):1384-1392.e3. doi: 10.1016/j.str.2018.06.011. Epub 2018 Aug 2. Structure. 2018. PMID: 30078642 Free PMC article.
This shows that the two CUB domains bind to two different chains of CPIII and that the N-terminal region of one CPIII chain, close to the proteolytic cleavage site, lies in the cleft between CUB1 and CUB2. ...
This shows that the two CUB domains bind to two different chains of CPIII and that the N-terminal region of one CPIII chain, close to …
Carving out a Glycoside Hydrolase Active Site for Incorporation into a New Protein Scaffold Using Deep Network Hallucination.
Hansen AL, Theisen FF, Crehuet R, Marcos E, Aghajari N, Willemoës M. Hansen AL, et al. ACS Synth Biol. 2024 Mar 15;13(3):862-875. doi: 10.1021/acssynbio.3c00674. Epub 2024 Feb 15. ACS Synth Biol. 2024. PMID: 38357862 Free PMC article.
Here, we present a strategy for the de novo design of a simplified scaffold of an endo-alpha-N-acetylgalactosaminidase active site, a glycoside hydrolase from the GH101 enzyme family. Using a combination of trRosetta hallucination, iterative cycles of deep-learning-based s …
Here, we present a strategy for the de novo design of a simplified scaffold of an endo-alpha-N-acetylgalactosaminidase active site, a …
Structuring detergents for extracting and stabilizing functional membrane proteins.
Matar-Merheb R, Rhimi M, Leydier A, Huché F, Galián C, Desuzinges-Mandon E, Ficheux D, Flot D, Aghajari N, Kahn R, Di Pietro A, Jault JM, Coleman AW, Falson P. Matar-Merheb R, et al. PLoS One. 2011 Mar 31;6(3):e18036. doi: 10.1371/journal.pone.0018036. PLoS One. 2011. PMID: 21483854 Free PMC article.
METHODOLOGY/PRINCIPAL FINDINGS: Anionic calix[4]arene based detergents (C4Cn, n=1-12) were designed to structure the membrane domains through hydrophobic interactions and a network of salt bridges with the basic residues found at the cytosol-membrane interface of membrane …
METHODOLOGY/PRINCIPAL FINDINGS: Anionic calix[4]arene based detergents (C4Cn, n=1-12) were designed to structure the membrane domains …
The ABC transporter BmrA from Bacillus subtilis is a functional dimer when in a detergent-solubilized state.
Ravaud S, Do Cao MA, Jidenko M, Ebel C, Le Maire M, Jault JM, Di Pietro A, Haser R, Aghajari N. Ravaud S, et al. Biochem J. 2006 Apr 15;395(2):345-53. doi: 10.1042/BJ20051719. Biochem J. 2006. PMID: 16405427 Free PMC article.
SEC data showed that BmrA could be purified in a functional form in 0.05 and 0.01% DDM (n-dodecyl-beta-D-maltoside) and was homogeneous and monodisperse with an R(s) (Stokes radius) of 5.6 nm that is compatible with a dimer structure. ...
SEC data showed that BmrA could be purified in a functional form in 0.05 and 0.01% DDM (n-dodecyl-beta-D-maltoside) and was homogeneo …
Enhancement of the thermostability and the catalytic efficiency of Bacillus pumilus CBS protease by site-directed mutagenesis.
Jaouadi B, Aghajari N, Haser R, Bejar S. Jaouadi B, et al. Biochimie. 2010 Apr;92(4):360-9. doi: 10.1016/j.biochi.2010.01.008. Epub 2010 Jan 21. Biochimie. 2010. PMID: 20096326
More interestingly, this mutation also shifted the optimum temperature from 65 degrees C to 75 degrees C and caused a prominent 31-fold increase in k(cat)/K(m) with N-succinyl-l-Ala-Ala-Pro-Phe-p-nitroanilide (AAPF). The L31I and T33S mutants were observed to improve mainl …
More interestingly, this mutation also shifted the optimum temperature from 65 degrees C to 75 degrees C and caused a prominent 31-fold incr …
The Immunomodulatory Effect of Radiofrequency Electromagnetic Field on Serum Cytokine Levels in A Mouse Model of Hindlimb Unloading.
Aghajari S, Mortazavi SMJ, Kalani M, Nematolahi S, Habibzadeh P, Farjadian S. Aghajari S, et al. Cell J. 2021 Jan;22(4):401-405. doi: 10.22074/cellj.2021.6856. Epub 2020 Apr 22. Cell J. 2021. PMID: 32347032 Free PMC article.
MATERIALS AND METHODS: In this experimental study, serum levels of T helper (Th)-mediated cytokines were determined by the multiplex cytometric bead assay in four groups of mice (n=10 per group): HU mice, RF-EMF-treated mice, HU mice pre-exposed to RF-EMF; and untreated co …
MATERIALS AND METHODS: In this experimental study, serum levels of T helper (Th)-mediated cytokines were determined by the multiplex cytomet …
Biased mutagenesis in the N-terminal region by degenerate oligonucleotide gene shuffling enhances secretory expression of barley alpha-amylase 2 in yeast.
Fukuda K, Jensen MH, Haser R, Aghajari N, Svensson B. Fukuda K, et al. Protein Eng Des Sel. 2005 Nov;18(11):515-26. doi: 10.1093/protein/gzi057. Epub 2005 Sep 9. Protein Eng Des Sel. 2005. PMID: 16155115
Since different secretion levels of AMY1/AMY2 chimeras were previously ascribed to the N-terminal sequence, AMY1 residues were combinatorially introduced at the 10 non-conserved positions in His14-Gln49 of AMY2 using degenerate oligonucleotide gene shuffling (DOGS) coupled …
Since different secretion levels of AMY1/AMY2 chimeras were previously ascribed to the N-terminal sequence, AMY1 residues were combin …
Young People Are Willing to Intervene Against Rape Myths Online: A Simulated Social Media Experiment.
Nicolla S, McKenzie AH, Lazard AJ, DiFranzo D, Aghajari Z, Mao C, Dasgupta N. Nicolla S, et al. J Adolesc Health. 2025 May;76(5):839-846. doi: 10.1016/j.jadohealth.2025.01.006. Epub 2025 Feb 19. J Adolesc Health. 2025. PMID: 39969466
Participants were adolescents and young adults (n = 712) aged 18-25 years (M = 22.14, SD = 1.92). Participants randomly viewed social media posts with the following: (1) rape myth comments, (2) rape myth comments with bystander intervention comments, or (3) control conditi …
Participants were adolescents and young adults (n = 712) aged 18-25 years (M = 22.14, SD = 1.92). Participants randomly viewed social …
12 results