Synthesis and anticonvulsant activity of new 2-substituted-5- [2-(2-fluorophenoxy)phenyl]-1,3,4-oxadiazoles and 1,2,4-triazoles

Ali Almasirad; Sayyed A Tabatabai; Mehrdad Faizi; Abbas Kebriaeezadeh; Nazila Mehrabi; Afshin Dalvandi; Abbas Shafiee

doi:10.1016/j.bmcl.2004.09.072

Synthesis and anticonvulsant activity of new 2-substituted-5- [2-(2-fluorophenoxy)phenyl]-1,3,4-oxadiazoles and 1,2,4-triazoles

Bioorg Med Chem Lett. 2004 Dec 20;14(24):6057-9. doi: 10.1016/j.bmcl.2004.09.072.

Authors

Ali Almasirad¹, Sayyed A Tabatabai, Mehrdad Faizi, Abbas Kebriaeezadeh, Nazila Mehrabi, Afshin Dalvandi, Abbas Shafiee

Affiliation

¹ Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran.

PMID: 15546729
DOI: 10.1016/j.bmcl.2004.09.072

Abstract

A series of new 2-substituted-5-[2-(2-fluorophenoxy)phenyl]-1,3,4-oxadiazoles has been synthesized and screened for their anticonvulsant activities. Compound 3 shows considerable anticonvulsant activity both in PTZ and MES models. It seems that this effect is mediated by benzodiazepine receptors and other unknown mechanism, respectively.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anticonvulsants* / chemical synthesis
Anticonvulsants* / pharmacology
Drug Evaluation, Preclinical
Molecular Structure
Oxadiazoles* / chemical synthesis
Oxadiazoles* / pharmacology
Structure-Activity Relationship
Triazoles* / chemical synthesis
Triazoles* / pharmacology

Substances

Anticonvulsants
Oxadiazoles
Triazoles
1,2,4-triazole