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NCAM2/OCAM/RNCAM: cell adhesion molecule with a role in neuronal compartmentalization.
Winther M, Berezin V, Walmod PS. Winther M, et al. Int J Biochem Cell Biol. 2012 Mar;44(3):441-6. doi: 10.1016/j.biocel.2011.11.020. Epub 2011 Dec 2. Int J Biochem Cell Biol. 2012. PMID: 22155300 Review.
There are no known heterophilic NCAM2 binding partners, and NCAM2 is not glycosylated with polysialic acid, a posttranslational modification known to be a major modulator of NCAM1-mediated processes. This suggests that NCAM2 has a function or mode of action d …
There are no known heterophilic NCAM2 binding partners, and NCAM2 is not glycosylated with polysialic acid, a posttranslationa …
The Hidden Side of NCAM Family: NCAM2, a Key Cytoskeleton Organization Molecule Regulating Multiple Neural Functions.
Parcerisas A, Ortega-Gascó A, Pujadas L, Soriano E. Parcerisas A, et al. Int J Mol Sci. 2021 Sep 16;22(18):10021. doi: 10.3390/ijms221810021. Int J Mol Sci. 2021. PMID: 34576185 Free PMC article. Review.
Although it has been over 20 years since Neural Cell Adhesion Molecule 2 (NCAM2) was identified as the second member of the NCAM family with a high expression in the nervous system, the knowledge of NCAM2 is still eclipsed by NCAM1. ...Recent studies have revealed t …
Although it has been over 20 years since Neural Cell Adhesion Molecule 2 (NCAM2) was identified as the second member of the NCAM fami …
circ-Ncam2 (mmu_circ_0006413) Participates in LPS-Induced Microglia Activation and Neuronal Apoptosis via the TLR4/NF-kappaB Pathway.
Guo K, Chang Y, Jin Y, Yuan H, Che P. Guo K, et al. J Mol Neurosci. 2022 Aug;72(8):1738-1748. doi: 10.1007/s12031-022-02018-6. Epub 2022 Jun 10. J Mol Neurosci. 2022. PMID: 35687299
Spinal cord injury (SCI) can cause permanent neurological deficits. Circular RNA Ncam2 (circ-Ncam2 also termed mmu_circ_0006413) has been reported to be overexpressed in SCI mouse models. ...LPS stimulation promoted circ-Ncam2 expression in BV2 cells. Inhibit …
Spinal cord injury (SCI) can cause permanent neurological deficits. Circular RNA Ncam2 (circ-Ncam2 also termed mmu_circ_000641 …
NCAM2 Regulates Dendritic and Axonal Differentiation through the Cytoskeletal Proteins MAP2 and 14-3-3.
Parcerisas A, Pujadas L, Ortega-Gascó A, Perelló-Amorós B, Viais R, Hino K, Figueiro-Silva J, La Torre A, Trullás R, Simó S, Lüders J, Soriano E. Parcerisas A, et al. Cereb Cortex. 2020 May 18;30(6):3781-3799. doi: 10.1093/cercor/bhz342. Cereb Cortex. 2020. PMID: 32043120 Free PMC article.
Neural cell adhesion molecule 2 (NCAM2) is involved in the development and plasticity of the olfactory system. Genetic data have implicated the NCAM2 gene in neurodevelopmental disorders including Down syndrome and autism, although its role in cortical development i …
Neural cell adhesion molecule 2 (NCAM2) is involved in the development and plasticity of the olfactory system. Genetic data have impl …
Regulation of young-adult neurogenesis and neuronal differentiation by neural cell adhesion molecule 2 (NCAM2).
Ortega-Gascó A, Parcerisas A, Hino K, Herranz-Pérez V, Ulloa F, Elias-Tersa A, Bosch M, García-Verdugo JM, Simó S, Pujadas L, Soriano E. Ortega-Gascó A, et al. Cereb Cortex. 2023 Oct 14;33(21):10931-10948. doi: 10.1093/cercor/bhad340. Cereb Cortex. 2023. PMID: 37724425 Free PMC article.
Here we analyzed the functions of neural cell adhesion molecule 2 (NCAM2) in the regulation of RGPs in adult neurogenesis and during corticogenesis. We characterized the presence of NCAM2 across the main cell types of the neurogenic process in the dentate gyrus, rev …
Here we analyzed the functions of neural cell adhesion molecule 2 (NCAM2) in the regulation of RGPs in adult neurogenesis and during …
Deficiency in the neural cell adhesion molecule 2 (NCAM2) reduces axonal levels of beta-site amyloid precursor protein cleaving enzyme 1 (BACE1), affects axonal organization in the hippocampus, and leads to behavioral deficits.
Sah S, Keable R, Pfundstein G, Clemens KJ, Begg D, Schachner M, Leshchyns'ka I, Sytnyk V. Sah S, et al. Cereb Cortex. 2023 Sep 9;33(18):10047-10065. doi: 10.1093/cercor/bhad264. Cereb Cortex. 2023. PMID: 37522285
The neural cell adhesion molecule 2 (NCAM2) regulates axonal organization in the central nervous system via mechanisms that have remained poorly understood. ...This abnormal axonal organization correlates with impaired short-term spatial memory and cognitive flexibility in …
The neural cell adhesion molecule 2 (NCAM2) regulates axonal organization in the central nervous system via mechanisms that have rema …
NCAM2 Fibronectin type-III domains form a rigid structure that binds and activates the Fibroblast Growth Factor Receptor.
Rasmussen KK, Falkesgaard MH, Winther M, Roed NK, Quistgaard CL, Teisen MN, Edslev SM, Petersen DL, Aljubouri A, Christensen C, Thulstrup PW, Lo Leggio L, Teilum K, Walmod PS. Rasmussen KK, et al. Sci Rep. 2018 Jun 12;8(1):8957. doi: 10.1038/s41598-018-27089-7. Sci Rep. 2018. PMID: 29895898 Free PMC article.
NCAM1 and NCAM2 have ectodomains consisting of 5 Ig domains followed by 2 membrane-proximal FnIII domains. ...In NCAM1 binding of ATP to this motif interferes with NCAM1 binding to FGFR. We obtained a structural model of the NCAM2 FnIII2 domain by NMR spectroscopy, …
NCAM1 and NCAM2 have ectodomains consisting of 5 Ig domains followed by 2 membrane-proximal FnIII domains. ...In NCAM1 binding of ATP …
NCAM2 deletion in a boy with macrocephaly and autism: Cause, association or predisposition?
Scholz C, Steinemann D, Mälzer M, Roy M, Arslan-Kirchner M, Illig T, Schmidtke J, Stuhrmann M. Scholz C, et al. Eur J Med Genet. 2016 Oct;59(10):493-8. doi: 10.1016/j.ejmg.2016.08.006. Epub 2016 Sep 2. Eur J Med Genet. 2016. PMID: 27596683
Among many ASD-candidate genes, NCAM2 has been assumed to play a pivotal role in the development of ASD because of its function in the outgrowth and bundling of neurites. Our reported case raises the questions whether the NCAM2-deletion is the true cause of the ASD …
Among many ASD-candidate genes, NCAM2 has been assumed to play a pivotal role in the development of ASD because of its function in th …
Neural Cell Adhesion Molecule 2 (NCAM2)-Induced c-Src-Dependent Propagation of Submembrane Ca2+ Spikes Along Dendrites Inhibits Synapse Maturation.
Sheng L, Leshchyns'ka I, Sytnyk V. Sheng L, et al. Cereb Cortex. 2019 Apr 1;29(4):1439-1459. doi: 10.1093/cercor/bhy041. Cereb Cortex. 2019. PMID: 29522129
The neural cell adhesion molecule 2 (NCAM2) is encoded by a gene on chromosome 21 in humans. NCAM2 accumulates in synapses, but its role in regulation of synapse formation remains poorly understood. ...Inhibition of initiation or propagation of NCAM2-dependen …
The neural cell adhesion molecule 2 (NCAM2) is encoded by a gene on chromosome 21 in humans. NCAM2 accumulates in synapses, bu …
100 results