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1999 1
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2014 2
2015 5
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Page 1
A postzygotic de novo NCDN mutation identified in a sporadic FTLD patient results in neurochondrin haploinsufficiency and altered FUS granule dynamics.
Nicolas G, Sévigny M, Lecoquierre F, Marguet F, Deschênes A, Del Pelaez MC, Feuillette S, Audebrand A, Lecourtois M, Rousseau S, Richard AC, Cassinari K, Deramecourt V, Duyckaerts C, Boland A, Deleuze JF, Meyer V, Clarimon Echavarria J, Gelpi E, Akiyama H, Hasegawa M, Kawakami I, Wong TH, Van Rooij JGJ, Van Swieten JC, Campion D, Dutchak PA, Wallon D, Lavoie-Cardinal F, Laquerrière A, Rovelet-Lecrux A, Sephton CF. Nicolas G, et al. Acta Neuropathol Commun. 2022 Feb 12;10(1):20. doi: 10.1186/s40478-022-01314-x. Acta Neuropathol Commun. 2022. PMID: 35151370 Free PMC article.
Our study identifies the NCDN protein as a likely contributor of FTLD-FET pathophysiology. Moreover, we provide evidence for a negative feedback loop of toxicity between NCDN and FUS, where loss of NCDN alters FUS cytoplasmic dynamics, which in turn has an im …
Our study identifies the NCDN protein as a likely contributor of FTLD-FET pathophysiology. Moreover, we provide evidence for a negati …
NCDN is a Potential Biomarker and Therapeutic Target for Glioblastoma.
Huang X, Xu C, Dai H, Yang J, Huang T, Chen S, Qi L, Ruan J, Wang J. Huang X, et al. J Cancer. 2024 Jan 1;15(4):1067-1076. doi: 10.7150/jca.90535. eCollection 2024. J Cancer. 2024. PMID: 38230206 Free PMC article.
Background: Glioblastoma (GBM) is a type of central nervous system malignancy. In our study, we determined the effect of NCDN in GBM patients through The Cancer Genome Atlas (TCGA) data analysis, and studied the effects of NCDN on GBM cell function to estimate its p …
Background: Glioblastoma (GBM) is a type of central nervous system malignancy. In our study, we determined the effect of NCDN in GBM …
Monoallelic and bi-allelic variants in NCDN cause neurodevelopmental delay, intellectual disability, and epilepsy.
Fatima A, Hoeber J, Schuster J, Koshimizu E, Maya-Gonzalez C, Keren B, Mignot C, Akram T, Ali Z, Miyatake S, Tanigawa J, Koike T, Kato M, Murakami Y, Abdullah U, Ali MA, Fadoul R, Laan L, Castillejo-López C, Liik M, Jin Z, Birnir B, Matsumoto N, Baig SM, Klar J, Dahl N. Fatima A, et al. Am J Hum Genet. 2021 Apr 1;108(4):739-748. doi: 10.1016/j.ajhg.2021.02.015. Epub 2021 Mar 11. Am J Hum Genet. 2021. PMID: 33711248 Free PMC article.
Three siblings were found homozygous for a NCDN missense variant, whereas another three unrelated individuals carried different de novo missense variants in NCDN. We assayed the missense variants for their capability to rescue impaired neurite formation in human neu …
Three siblings were found homozygous for a NCDN missense variant, whereas another three unrelated individuals carried different de no …
Monoallelic and bi-allelic variants in NCDN cause neurodevelopmental delay, intellectual disability, and epilepsy.
Fatima A, Hoeber J, Schuster J, Koshimizu E, Maya-Gonzalez C, Keren B, Mignot C, Akram T, Ali Z, Miyatake S, Tanigawa J, Koike T, Kato M, Murakami Y, Abdullah U, Ali MA, Fadoul R, Laan L, Castillejo-López C, Liik M, Jin Z, Birnir B, Matsumoto N, Baig SM, Klar J, Dahl N. Fatima A, et al. Am J Hum Genet. 2022 Mar 3;109(3):542-546. doi: 10.1016/j.ajhg.2022.02.007. Am J Hum Genet. 2022. PMID: 35245475 Free PMC article. No abstract available.
Operant Training for Highly Palatable Food Alters Translating Messenger RNA in Nucleus Accumbens D(2) Neurons and Reveals a Modulatory Role of Ncdn.
Montalban E, Giralt A, Taing L, Nakamura Y, Pelosi A, Brown M, de Pins B, Valjent E, Martin M, Nairn AC, Greengard P, Flajolet M, Hervé D, Gambardella N, Roussarie JP, Girault JA. Montalban E, et al. Biol Psychiatry. 2024 May 15;95(10):926-937. doi: 10.1016/j.biopsych.2023.08.006. Epub 2023 Aug 12. Biol Psychiatry. 2024. PMID: 37579933
We tested the consequences of invalidation of an abundant downregulated gene, Ncdn. RESULTS: Operant conditioning for highly palatable food increased motivation for food even in well-fed mice. ...CONCLUSIONS: Our results emphasize the importance of messenger RNA alteration …
We tested the consequences of invalidation of an abundant downregulated gene, Ncdn. RESULTS: Operant conditioning for highly palatabl …
Fabrication of Multiresponsive Magnetic Nanocomposite Double-Network Hydrogels for Controlled Release Applications.
Lu CH, Yeh YC. Lu CH, et al. Small. 2021 Dec;17(52):e2105997. doi: 10.1002/smll.202105997. Epub 2021 Nov 17. Small. 2021. PMID: 34791796
Here, a new type of ncDN hydrogels featuring definable microstructures and properties as well as multistimuli responsiveness for controlled release applications is developed. ...Taken together, a versatile ncDN hydrogel platform capable of multistimuli responsivenes …
Here, a new type of ncDN hydrogels featuring definable microstructures and properties as well as multistimuli responsiveness for cont …
In situ formation of nanocomposite double-network hydrogels with shear-thinning and self-healing properties.
Tsai TY, Shen KH, Chang CW, Jovanska L, Wang R, Yeh YC. Tsai TY, et al. Biomater Sci. 2021 Feb 9;9(3):985-999. doi: 10.1039/d0bm01528h. Biomater Sci. 2021. PMID: 33300914
Besides, the designed TEG-CS/PDA/PBA-rGO ncDN hydrogels were cytocompatible and also exhibited antibacterial activity. Taken together, we hereby provide a nanomaterial approach to fabricate a new class of ncDN hydrogels with tailorable networks and favorite properti …
Besides, the designed TEG-CS/PDA/PBA-rGO ncDN hydrogels were cytocompatible and also exhibited antibacterial activity. Taken together …
FoxO3a negatively regulates nerve growth factor-induced neuronal differentiation through inhibiting the expression of neurochondrin in PC12 cells.
Wang H, Duan X, Ren Y, Liu Y, Huang M, Liu P, Wang R, Gao G, Zhou L, Feng Z, Zheng W. Wang H, et al. Mol Neurobiol. 2013 Feb;47(1):24-36. doi: 10.1007/s12035-012-8357-7. Epub 2012 Oct 21. Mol Neurobiol. 2013. PMID: 23086522
These results indicate that NCDN is a direct downstream target of FoxO3a which negatively regulates the expression of NCDN. ...Moreover, knockdown of NCDN by siRNA blocked NGF-induced neuronal differentiation of PC12 cells while overexpression of NCDN
These results indicate that NCDN is a direct downstream target of FoxO3a which negatively regulates the expression of NCDN. .. …
Neurochondrin interacts with the SMN protein suggesting a novel mechanism for spinal muscular atrophy pathology.
Thompson LW, Morrison KD, Shirran SL, Groen EJN, Gillingwater TH, Botting CH, Sleeman JE. Thompson LW, et al. J Cell Sci. 2018 Apr 17;131(8):jcs211482. doi: 10.1242/jcs.211482. J Cell Sci. 2018. PMID: 29507115 Free PMC article.
NCDN has roles in protein localisation in neural cells and in maintenance of cell polarity. NCDN is required for the correct localisation of SMN, suggesting they may both be required for formation and transport of trafficking vesicles. ...
NCDN has roles in protein localisation in neural cells and in maintenance of cell polarity. NCDN is required for the correct l
Functions and mechanisms of the GPCR adaptor protein Norbin.
Chetwynd SA, Andrews S, Inglesfield S, Delon C, Ktistakis NT, Welch HCE. Chetwynd SA, et al. Biochem Soc Trans. 2023 Aug 31;51(4):1545-1558. doi: 10.1042/BST20221349. Biochem Soc Trans. 2023. PMID: 37503670 Free PMC article. Review.
Norbin (Neurochondrin, NCDN) is a highly conserved 79 kDa adaptor protein that was first identified more than a quarter of a century ago as a gene up-regulated in rat hippocampus upon induction of long-term potentiation. ...
Norbin (Neurochondrin, NCDN) is a highly conserved 79 kDa adaptor protein that was first identified more than a quarter of a century …
45 results