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1994 1
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844 results

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Page 1
NCOR1 maintains the homeostasis of vascular smooth muscle cells and protects against aortic aneurysm.
Du LJ, Sun JY, Zhang WC, Liu Y, Liu Y, Lin WZ, Liu T, Zhu H, Wang YL, Shao S, Zhou LJ, Chen BY, Lu H, Li RG, Jia F, Duan SZ. Du LJ, et al. Cell Death Differ. 2023 Mar;30(3):618-631. doi: 10.1038/s41418-022-01065-1. Epub 2022 Sep 23. Cell Death Differ. 2023. PMID: 36151473 Free PMC article.
NCOR1 modulated VSMC phenotype through 3 different mechanisms. First, NCOR1 deficiency increased acetylated FOXO3a to inhibit the expression of Myocd, which downregulated contractile genes. ...Manipulation of smooth muscle NCOR1 may be a potential approach fo …
NCOR1 modulated VSMC phenotype through 3 different mechanisms. First, NCOR1 deficiency increased acetylated FOXO3a to inhibit …
NCOR1-a new player on the field of T cell development.
Müller L, Hainberger D, Stolz V, Ellmeier W. Müller L, et al. J Leukoc Biol. 2018 Dec;104(6):1061-1068. doi: 10.1002/JLB.1RI0418-168R. Epub 2018 Aug 17. J Leukoc Biol. 2018. PMID: 30117609 Review.
Although identified more than 20 years ago as a corepressor of nuclear receptors, the role of NCOR1 in T cells remained only poorly understood. However, recent studies indicate that the survival of developing thymocytes is regulated by NCOR1, revealing an essential …
Although identified more than 20 years ago as a corepressor of nuclear receptors, the role of NCOR1 in T cells remained only poorly u …
Insights into the function of HDAC3 and NCoR1/NCoR2 co-repressor complex in metabolic diseases.
Paluvai H, Shanmukha KD, Tyedmers J, Backs J. Paluvai H, et al. Front Mol Biosci. 2023 Aug 22;10:1190094. doi: 10.3389/fmolb.2023.1190094. eCollection 2023. Front Mol Biosci. 2023. PMID: 37674539 Free PMC article. Review.
Histone deacetylase 3 (HDAC3) and nuclear receptor co-repressor (NCoR1/2) are epigenetic regulators that play a key role in gene expression and metabolism. ...In this review, we summarize the current understanding of individual functions of HDAC3 and NCoR1/2 and the …
Histone deacetylase 3 (HDAC3) and nuclear receptor co-repressor (NCoR1/2) are epigenetic regulators that play a key role in gene expr …
NCoR1 controls immune tolerance in conventional dendritic cells by fine-tuning glycolysis and fatty acid oxidation.
Sen K, Pati R, Jha A, Mishra GP, Prusty S, Chaudhary S, Swetalika S, Podder S, Sen A, Swain M, Nanda RK, Raghav SK. Sen K, et al. Redox Biol. 2023 Feb;59:102575. doi: 10.1016/j.redox.2022.102575. Epub 2022 Dec 16. Redox Biol. 2023. PMID: 36565644 Free PMC article.
These findings suggested strong involvement of NCoR1 in immune tolerance. Our validation in primary human monocyte-derived DCs (moDCs) showed diminished NCOR1 expression in dexamethasone-derived tolerogenic moDCs along with suppression of CD4(+)T cell proliferation …
These findings suggested strong involvement of NCoR1 in immune tolerance. Our validation in primary human monocyte-derived DCs (moDCs …
Autophagy-mediated NCOR1 degradation is required for brown fat maturation and thermogenesis.
Sabaté-Pérez A, Romero M, Sànchez-Fernàndez-de-Landa P, Carobbio S, Mouratidis M, Sala D, Engel P, Martínez-Cristóbal P, Villena JA, Virtue S, Vidal-Puig A, Palacín M, Testar X, Zorzano A. Sabaté-Pérez A, et al. Autophagy. 2023 Mar;19(3):904-925. doi: 10.1080/15548627.2022.2111081. Epub 2022 Aug 25. Autophagy. 2023. PMID: 35947488 Free PMC article.
Mechanistically, TP53INP2 stimulates PPARG activity and adipogenesis in brown adipose cells by promoting the autophagic degradation of NCOR1, a PPARG co-repressor. Moreover, the modulation of TP53INP2 expression in BAT and in human brown adipocytes suggests that this prote …
Mechanistically, TP53INP2 stimulates PPARG activity and adipogenesis in brown adipose cells by promoting the autophagic degradation of NC …
p21-activated kinase 4 suppresses fatty acid beta-oxidation and ketogenesis by phosphorylating NCoR1.
Shi MY, Yu HC, Han CY, Bang IH, Park HS, Jang KY, Lee S, Son JB, Kim ND, Park BH, Bae EJ. Shi MY, et al. Nat Commun. 2023 Aug 17;14(1):4987. doi: 10.1038/s41467-023-40597-z. Nat Commun. 2023. PMID: 37591884 Free PMC article.
PPARalpha corepressor NCoR1 is a key regulator of fatty acid beta-oxidation and ketogenesis. However, its regulatory mechanism is largely unknown. Here, we report that oncoprotein p21-activated kinase 4 (PAK4) is an NCoR1 kinase. Specifically, PAK4 phosphorylates …
PPARalpha corepressor NCoR1 is a key regulator of fatty acid beta-oxidation and ketogenesis. However, its regulatory mechanism is lar …
Ncor1 Deficiency Promotes Osteoclastogenesis and Exacerbates Periodontitis.
Ma XX, Meng XQ, Wang YL, Liu Y, Shi XR, Shao S, Duan SZ, Lu HX. Ma XX, et al. J Dent Res. 2023 Jan;102(1):72-81. doi: 10.1177/00220345221116927. Epub 2022 Aug 18. J Dent Res. 2023. PMID: 35983582
However, the role of Ncor1 in periodontitis has not been elucidated. The aims of the present study were to investigate the role of Ncor1 in experimental periodontitis and to explore the underlying mechanisms through an experimental periodontitis model in myeloid cel …
However, the role of Ncor1 in periodontitis has not been elucidated. The aims of the present study were to investigate the role of …
Role of NCoR1 in mitochondrial function and energy metabolism.
Lima TI, Valentim RR, Araújo HN, Oliveira AG, Favero BC, Menezes ES, Araújo R, Silveira LR. Lima TI, et al. Cell Biol Int. 2018 Jun;42(6):734-741. doi: 10.1002/cbin.10973. Epub 2018 May 8. Cell Biol Int. 2018. PMID: 29660213 Review.
Recent evidence has shown that the nuclear corepressor NCoR1 is an essential metabolic switch which acts on oxidative metabolism signaling. Here, we provide an overview of the emerging role of NCoR1 in the transcriptional control of energy metabolism. The identifica …
Recent evidence has shown that the nuclear corepressor NCoR1 is an essential metabolic switch which acts on oxidative metabolism sign …
NCoR1 limits angiogenic capacity by altering Notch signaling.
Teichmann T, Malacarne P, Zehr S, Günther S, Pflüger-Müller B, Warwick T, Brandes RP. Teichmann T, et al. J Mol Cell Cardiol. 2024 Mar;188:65-78. doi: 10.1016/j.yjmcc.2024.02.003. Epub 2024 Feb 15. J Mol Cell Cardiol. 2024. PMID: 38359551 Free article.
Confrontation assays comparing cells with and without NCoR1-deficiency revealed that loss of NCoR1 promotes a tip-cell position during spheroid sprouting. ...Luciferase assays showed that siRNA-mediated knockdown of NCOR1 promotes RBPJk activity. Furthermore, …
Confrontation assays comparing cells with and without NCoR1-deficiency revealed that loss of NCoR1 promotes a tip-cell positio …
NCoR1: a key player regulating mycobacterium tuberculosis pathogenesis.
Sen K, Biswas VK, Ghosh A, Prusty S, Nayak SP, Podder S, Gupta B, Raghav SK. Sen K, et al. Autophagy. 2024 Mar;20(3):697-698. doi: 10.1080/15548627.2023.2277583. Epub 2023 Nov 12. Autophagy. 2024. PMID: 37953605 Free PMC article.
Additionally, exogenous NCOR1 expression rescues the AMPK-MTOR-TFEB signaling axis and essentially the autophagic induction machinery. Overall, these findings demonstrate a crucial role of NCOR1 in regulating Mtb pathogenesis within myeloid cells and sheds light tow …
Additionally, exogenous NCOR1 expression rescues the AMPK-MTOR-TFEB signaling axis and essentially the autophagic induction machinery …
844 results