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844 results

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Page 1
NEDD4L mediates intestinal epithelial cell ferroptosis to restrict inflammatory bowel diseases and colorectal tumorigenesis.
Liang J, Wang N, Yao Y, Wang Y, An X, Wang H, Liu H, Jiang Y, Li H, Cheng X, Xu J, Liang X, Lou J, Xin Z, Zhang T, Wang X, Lin W. Liang J, et al. J Clin Invest. 2024 Dec 17;135(3):e173994. doi: 10.1172/JCI173994. J Clin Invest. 2024. PMID: 39688910 Free PMC article.
NEDD4L expression was significantly inhibited in intestinal epithelial cells (IECs) of patients with Crohn's disease, ulcerative colitis, and CRC. ...Importantly, ferroptosis inhibitors reduced the susceptibility of NEDD4L-deficient mice to colitis and colitis-assoc …
NEDD4L expression was significantly inhibited in intestinal epithelial cells (IECs) of patients with Crohn's disease, ulcerative coli …
Research progress of Nedd4L in cardiovascular diseases.
Li M, Sun G, Wang P, Wang W, Cao K, Song C, Sun Y, Zhang Y, Zhang N. Li M, et al. Cell Death Discov. 2022 Apr 16;8(1):206. doi: 10.1038/s41420-022-01017-1. Cell Death Discov. 2022. PMID: 35429991 Free PMC article. Review.
Nedd4 family is the largest group of ubiquitin ligases, including 9 members, such as Nedd4-1, Nedd4L (Nedd4-2), WWP1, WWP2, ITCH, etc. They could bind to substrate proteins through their WW domain and play a dominant role in the ubiquitination process, and then participate …
Nedd4 family is the largest group of ubiquitin ligases, including 9 members, such as Nedd4-1, Nedd4L (Nedd4-2), WWP1, WWP2, ITCH, etc …
NEDD4L in human tumors: regulatory mechanisms and dual effects on anti-tumor and pro-tumor.
Zhang M, Zhang Z, Tian X, Zhang E, Wang Y, Tang J, Zhao J. Zhang M, et al. Front Pharmacol. 2023 Nov 9;14:1291773. doi: 10.3389/fphar.2023.1291773. eCollection 2023. Front Pharmacol. 2023. PMID: 38027016 Free PMC article. Review.
NEDD4L primarily functions as a tumor suppressor in several tumors but also plays an oncogenic role in certain tumors. ...Overall, therapeutic strategies targeting NEDD4L to treat cancer may be feasible....
NEDD4L primarily functions as a tumor suppressor in several tumors but also plays an oncogenic role in certain tumors. ...Overall, th …
NEDD4L mediates ITGB4 ubiquitination and degradation to suppress esophageal carcinoma progression.
Shi Y, Fang N, Wu Y, Xu H, Ning A, Zhang W, Liu Y, Tao X, Chen Q, Tian T, Zhang L, Chu M, Cui J. Shi Y, et al. Cell Commun Signal. 2024 Jun 3;22(1):302. doi: 10.1186/s12964-024-01685-9. Cell Commun Signal. 2024. PMID: 38831335 Free PMC article.
However, the anti-tumor role of NEDD4L in esophageal carcinoma, and the potential specific recognition substrate remain unclear. ...Experiments in vivo and in vitro also verified that NEDD4L suppressed the growth and metastasis of esophageal carcinoma. Based on co-i …
However, the anti-tumor role of NEDD4L in esophageal carcinoma, and the potential specific recognition substrate remain unclear. ...E …
The Nedd4L ubiquitin ligase is activated by FCHO2-generated membrane curvature.
Sakamoto Y, Uezu A, Kikuchi K, Kang J, Fujii E, Moroishi T, Suetsugu S, Nakanishi H. Sakamoto Y, et al. EMBO J. 2024 Dec;43(23):5883-5909. doi: 10.1038/s44318-024-00268-1. Epub 2024 Oct 14. EMBO J. 2024. PMID: 39402328 Free PMC article.
FCHO2 was required for the Nedd4L-mediated ubiquitination and endocytosis of ENaC, with Nedd4L co-localizing with FCHO2 at clathrin-coated pits. In cells, Nedd4L was specifically recruited to, and activated by, the FCHO2 BAR domain. Furthermore, we reconstitu …
FCHO2 was required for the Nedd4L-mediated ubiquitination and endocytosis of ENaC, with Nedd4L co-localizing with FCHO2 at cla …
A novel NEDD4L-TXNIP-CHOP axis in the pathogenesis of nonalcoholic steatohepatitis.
Guo Q, Xin M, Lu Q, Feng D, Yang V, Peng LF, Whelan KA, Hu W, Wu S, Yang X, Wang H, Rothberg BS, Gamero AM, Gerhard GS, Gao B, Yang L. Guo Q, et al. Theranostics. 2023 Apr 9;13(7):2210-2225. doi: 10.7150/thno.81192. eCollection 2023. Theranostics. 2023. PMID: 37153733 Free PMC article.
Methods and Results: Using four independent NASH mouse models, we found that TXNIP protein abnormally accumulated in NASH mouse livers. A decrease in E3 ubiquitin ligase NEDD4L resulted in impaired TXNIP ubiquitination and its accumulation in the liver. TXNIP protein level …
Methods and Results: Using four independent NASH mouse models, we found that TXNIP protein abnormally accumulated in NASH mouse livers. A de …
Cytoplasmic YAP1-mediated ESCRT-III assembly promotes autophagic cell death and is ubiquitinated by NEDD4L in breast cancer.
Guo Y, Cui Y, Li Y, Jin X, Wang D, Lei M, Chen F, Liu Y, Xu J, Yao G, Zeng G, Chen X. Guo Y, et al. Cancer Commun (Lond). 2023 May;43(5):582-612. doi: 10.1002/cac2.12417. Epub 2023 Apr 2. Cancer Commun (Lond). 2023. PMID: 37005481 Free PMC article.
YAP1 binding to NEDD4-like E3 ubiquitin protein ligase (NEDD4L) was identified using mass spectrometry and was verified in vitro. Breast tissue microarrays were used to analyze the relationship between cytoplasmic YAP1 expression and the survival of breast cancer patients. …
YAP1 binding to NEDD4-like E3 ubiquitin protein ligase (NEDD4L) was identified using mass spectrometry and was verified in vitro. Bre …
NEDD4 and NEDD4L: Ubiquitin Ligases Closely Related to Digestive Diseases.
Xu J, Jiang W, Hu T, Long Y, Shen Y. Xu J, et al. Biomolecules. 2024 May 13;14(5):577. doi: 10.3390/biom14050577. Biomolecules. 2024. PMID: 38785984 Free PMC article. Review.
Numerous studies have shown that NEDD4 and NEDD4L of the NEDD4 family can regulate the digestive function, as well as a series of related physiological and pathological processes, by controlling the subsequent degradation of proteins such as PTEN, c-Myc, and P21, along wit …
Numerous studies have shown that NEDD4 and NEDD4L of the NEDD4 family can regulate the digestive function, as well as a series of rel …
NEDD4L induces mitochondrial dysfunction and neurodegeneration by promoting LIPT2 degradation in Huntington's disease.
Fan P, Liu Y, Liu C, Yao H, Xu S, Jiang Y, Wu Y, Liu Y, Guo X. Fan P, et al. Proc Natl Acad Sci U S A. 2025 Jul 22;122(29):e2503342122. doi: 10.1073/pnas.2503342122. Epub 2025 Jul 15. Proc Natl Acad Sci U S A. 2025. PMID: 40663606 Free PMC article.
Overexpression of NEDD4L leads to degeneration and cell death of medium spiny neurons (MSNs), along with a reduction in motor activities. ...Mechanistically, NEDD4L disrupts mitochondrial function by binding to lipoyl(octanoyl) transferase 2 (LIPT2) and promoting it …
Overexpression of NEDD4L leads to degeneration and cell death of medium spiny neurons (MSNs), along with a reduction in motor activit …
NEDD4L-Mediated Ubiquitination of GPX4 Exacerbates Doxorubicin-Induced Cardiotoxicity.
Ke J, Li L, Chen S, Liao C, Peng F, Chai D, Lin J. Ke J, et al. Int J Mol Sci. 2025 Aug 23;26(17):8201. doi: 10.3390/ijms26178201. Int J Mol Sci. 2025. PMID: 40943126 Free PMC article.
NEDD4L knockdown alleviated DIC, as well as ferroptosis and apoptosis in cardiomyocytes. ...Knockdown of NEDD4L reduced DOX-induced GPX4 ubiquitination levels and subsequent degradation. Notably, while NEDD4L knockdown mitigated DOX-induced cell death, concur …
NEDD4L knockdown alleviated DIC, as well as ferroptosis and apoptosis in cardiomyocytes. ...Knockdown of NEDD4L reduced DOX-in …
844 results