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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1999 1
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2008 5
2009 6
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2011 15
2012 13
2013 23
2014 17
2015 14
2016 9
2017 10
2018 11
2019 13
2020 22
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2023 14
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197 results

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Page 1
Negr1 controls adult hippocampal neurogenesis and affective behaviors.
Noh K, Lee H, Choi TY, Joo Y, Kim SJ, Kim H, Kim JY, Jahng JW, Lee S, Choi SY, Lee SJ. Noh K, et al. Mol Psychiatry. 2019 Aug;24(8):1189-1205. doi: 10.1038/s41380-018-0347-3. Epub 2019 Jan 16. Mol Psychiatry. 2019. PMID: 30651602
In this research, we characterized Negr1-deficient (negr1(-/-)) mice to elucidate the function of Negr1 in anxiety and depression. ...Taken together, our data uncovered a novel mechanism of mood regulation by Negr1 involving an interaction between N
In this research, we characterized Negr1-deficient (negr1(-/-)) mice to elucidate the function of Negr1 in anxiety and …
Major depression-related factor NEGR1 controls salivary secretion in mouse submandibular glands.
Lee J, Kim S, Lee B, Kim YB, Kim KH, Chung G, Lee SJ, Lee S, Sun W, Park HK, Choi SY. Lee J, et al. iScience. 2023 Apr 26;26(5):106773. doi: 10.1016/j.isci.2023.106773. eCollection 2023 May 19. iScience. 2023. PMID: 37216094 Free PMC article.
Here, we studied the function of Neuronal growth regulator 1 (NEGR1) in the salivary gland cells. NEGR1 was also expressed in mouse and human salivary glands. The structure of salivary glands of Negr1 knockout (KO) mice was normal. Negr1 KO mice showed …
Here, we studied the function of Neuronal growth regulator 1 (NEGR1) in the salivary gland cells. NEGR1 was also expressed in …
Depression-Associated Negr1 Gene-Deficiency Induces Alterations in the Monoaminergic Neurotransmission Enhancing Time-Dependent Sensitization to Amphetamine in Male Mice.
Kaare M, Jayaram M, Jagomäe T, Singh K, Kilk K, Mikheim K, Leevik M, Leidmaa E, Varul J, Nõmm H, Rähn K, Visnapuu T, Plaas M, Lilleväli K, Schäfer MKE, Philips MA, Vasar E. Kaare M, et al. Brain Sci. 2022 Dec 10;12(12):1696. doi: 10.3390/brainsci12121696. Brain Sci. 2022. PMID: 36552158 Free PMC article.
Although the linkage between NEGR1 and depression is the strongest, evidence also suggests the involvement of NEGR1 in a wide spectrum of psychiatric conditions. Here we show the expression of NEGR1 both in tyrosine- and tryptophan hydroxylase-positive cells. …
Although the linkage between NEGR1 and depression is the strongest, evidence also suggests the involvement of NEGR1 in a wide …
Negr1-Derived Peptides Trigger ALK Degradation and Halt Neuroblastoma Progression In Vitro and In Vivo.
Pischedda F, Ghirelli A, Tripathi V, Piccoli G. Pischedda F, et al. Pharmaceutics. 2023 Sep 12;15(9):2307. doi: 10.3390/pharmaceutics15092307. Pharmaceutics. 2023. PMID: 37765276 Free PMC article.
The expression of the IgLON family results altered in different cancers. We found that the IgLON member Negr1 is downregulated in neuroblastoma. The ectopic overexpression of Negr1 impairs neuroblastoma growth in vitro and in vivo. ...We generated and characterized …
The expression of the IgLON family results altered in different cancers. We found that the IgLON member Negr1 is downregulated in neu …
Depression-Associated Gene Negr1-Fgfr2 Pathway Is Altered by Antidepressant Treatment.
Carboni L, Pischedda F, Piccoli G, Lauria M, Musazzi L, Popoli M, Mathé AA, Domenici E. Carboni L, et al. Cells. 2020 Jul 31;9(8):1818. doi: 10.3390/cells9081818. Cells. 2020. PMID: 32751911 Free PMC article.
The Negr1 gene has been significantly associated with major depression in genetic studies. ...Negr1 and Adam10 were the genes mostly affected by antidepressant treatment, and in opposite directions. ...
The Negr1 gene has been significantly associated with major depression in genetic studies. ...Negr1 and Adam10 were the genes …
Placental NEGR1 DNA methylation is associated with BMI and neurodevelopment in preschool-age children.
Breton E, Gagné-Ouellet V, Thibeault K, Guérin R, Van Lieshout R, Perron P, Hivert M, Bouchard L. Breton E, et al. Epigenetics. 2020 Mar;15(3):323-335. doi: 10.1080/15592294.2019.1666653. Epub 2019 Sep 23. Epigenetics. 2020. PMID: 31510847 Free PMC article.
DNA methylation (DNAm) might enable foetal adaptations to environmental adversities through important gene loci. NEGR1 is involved in both energy balance and behaviour regulation. The aim of this study was to investigate associations between placental DNAm at the NEGR1
DNA methylation (DNAm) might enable foetal adaptations to environmental adversities through important gene loci. NEGR1 is involved in …
Neural cell adhesion molecule Negr1 deficiency in mouse results in structural brain endophenotypes and behavioral deviations related to psychiatric disorders.
Singh K, Jayaram M, Kaare M, Leidmaa E, Jagomäe T, Heinla I, Hickey MA, Kaasik A, Schäfer MK, Innos J, Lilleväli K, Philips MA, Vasar E. Singh K, et al. Sci Rep. 2019 Apr 1;9(1):5457. doi: 10.1038/s41598-019-41991-8. Sci Rep. 2019. PMID: 30932003 Free PMC article.
Furthermore, decreased number of parvalbumin-positive inhibitory interneurons was evident in Negr1(-/-) hippocampi. Behaviorally, Negr1(-/-) mice displayed hyperactivity in social interactions and impairments in social hierarchy. Finally, Negr1 deficiency res …
Furthermore, decreased number of parvalbumin-positive inhibitory interneurons was evident in Negr1(-/-) hippocampi. Behaviorally, …
Environment and Gene Association With Obesity and Their Impact on Neurodegenerative and Neurodevelopmental Diseases.
Flores-Dorantes MT, Díaz-López YE, Gutiérrez-Aguilar R. Flores-Dorantes MT, et al. Front Neurosci. 2020 Aug 28;14:863. doi: 10.3389/fnins.2020.00863. eCollection 2020. Front Neurosci. 2020. PMID: 32982666 Free PMC article. Review.
Moreover, in the last decades, the discovery of new genes associated with obesity (FTO, NRXN3, NPC1, NEGR1, MTCH2, GNPDA2, among others) and with neurodegenerative or neurodevelopmental diseases (APOE, CD38, SIRT1, TNFalpha, PAI-1, TREM2, SYT4, FMR1, TET3, among others) ha …
Moreover, in the last decades, the discovery of new genes associated with obesity (FTO, NRXN3, NPC1, NEGR1, MTCH2, GNPDA2, among othe …
NEGR1 and FGFR2 cooperatively regulate cortical development and core behaviours related to autism disorders in mice.
Szczurkowska J, Pischedda F, Pinto B, Managò F, Haas CA, Summa M, Bertorelli R, Papaleo F, Schäfer MK, Piccoli G, Cancedda L. Szczurkowska J, et al. Brain. 2018 Sep 1;141(9):2772-2794. doi: 10.1093/brain/awy190. Brain. 2018. PMID: 30059965 Free PMC article.
Accordingly, FGFR2 overexpression rescues all defects due to Negr1 knockdown in vivo. Negr1 knockout mice present phenotypes similar to Negr1-downregulated animals. These data indicate that NEGR1 and FGFR2 cooperatively regulate cortical development an …
Accordingly, FGFR2 overexpression rescues all defects due to Negr1 knockdown in vivo. Negr1 knockout mice present phenotypes s …
High-Fat Diet Induces Pre-Diabetes and Distinct Sex-Specific Metabolic Alterations in Negr1-Deficient Mice.
Kaare M, Mikheim K, Lilleväli K, Kilk K, Jagomäe T, Leidmaa E, Piirsalu M, Porosk R, Singh K, Reimets R, Taalberg E, Schäfer MKE, Plaas M, Vasar E, Philips MA. Kaare M, et al. Biomedicines. 2021 Sep 3;9(9):1148. doi: 10.3390/biomedicines9091148. Biomedicines. 2021. PMID: 34572334 Free PMC article.
In the large GWAS studies, NEGR1 gene has been one of the most significant gene loci for body mass phenotype. The purpose of the current study was to clarify the role of NEGR1 in the maintenance of systemic metabolism, including glucose homeostasis, by using both ma …
In the large GWAS studies, NEGR1 gene has been one of the most significant gene loci for body mass phenotype. The purpose of the curr …
197 results