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222 results

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Page 1
Negr1 controls adult hippocampal neurogenesis and affective behaviors.
Noh K, Lee H, Choi TY, Joo Y, Kim SJ, Kim H, Kim JY, Jahng JW, Lee S, Choi SY, Lee SJ. Noh K, et al. Mol Psychiatry. 2019 Aug;24(8):1189-1205. doi: 10.1038/s41380-018-0347-3. Epub 2019 Jan 16. Mol Psychiatry. 2019. PMID: 30651602
In this research, we characterized Negr1-deficient (negr1(-/-)) mice to elucidate the function of Negr1 in anxiety and depression. ...Taken together, our data uncovered a novel mechanism of mood regulation by Negr1 involving an interaction between N …
In this research, we characterized Negr1-deficient (negr1(-/-)) mice to elucidate the function of Negr1 in anxiety and …
miR-122/NEGR1 axis contributes colorectal cancer liver metastasis by PI3K/AKT pathway and macrophage modulation.
Dai S, Zhuang H, Li Z, Chen Z, Chai Y, Zhou Q. Dai S, et al. J Transl Med. 2024 Nov 25;22(1):1060. doi: 10.1186/s12967-024-05901-5. J Transl Med. 2024. PMID: 39587606 Free PMC article.
Results showed increased miR-122 and decreased NEGR1 in liver metastases compared to primary tumors. The miR-122/NEGR1 axis enhanced CRC cell proliferation, migration, invasion, and affected the PI3K/AKT pathway. Furthermore, reduced NEGR1 promoted M2 macroph …
Results showed increased miR-122 and decreased NEGR1 in liver metastases compared to primary tumors. The miR-122/NEGR1 axis en …
NEGR1 Modulates Mouse Affective Discrimination by Regulating Adult Olfactory Neurogenesis.
Kim KH, Noh K, Lee J, Lee S, Lee SJ. Kim KH, et al. Biol Psychiatry Glob Open Sci. 2024 Jun 23;4(5):100355. doi: 10.1016/j.bpsgos.2024.100355. eCollection 2024 Sep. Biol Psychiatry Glob Open Sci. 2024. PMID: 39170714 Free PMC article.
RESULTS: When encountering mice exposed to restraint stress or chronic pain, wild-type mice discriminated between them by either approaching the stressed mouse or avoiding the painful mouse, whereas Negr1 (-/-) mice showed unbiased social interactions with them. Next, we d …
RESULTS: When encountering mice exposed to restraint stress or chronic pain, wild-type mice discriminated between them by either approaching …
Negr1-Derived Peptides Trigger ALK Degradation and Halt Neuroblastoma Progression In Vitro and In Vivo.
Pischedda F, Ghirelli A, Tripathi V, Piccoli G. Pischedda F, et al. Pharmaceutics. 2023 Sep 12;15(9):2307. doi: 10.3390/pharmaceutics15092307. Pharmaceutics. 2023. PMID: 37765276 Free PMC article.
The expression of the IgLON family results altered in different cancers. We found that the IgLON member Negr1 is downregulated in neuroblastoma. The ectopic overexpression of Negr1 impairs neuroblastoma growth in vitro and in vivo. ...We generated and characterized …
The expression of the IgLON family results altered in different cancers. We found that the IgLON member Negr1 is downregulated in neu …
Elevated NEGR1 in brain induces anxiety or depression-like phenotypes and synaptic dysfunction.
Zhang YQ, Zhang Q, Yang Y, Yu LL, Fan NL, Wu Y, Wang JY, Dang XL, Guo YQ, Li C, Ma GL, Wang L, Guo YB, Li SW. Zhang YQ, et al. Mol Psychiatry. 2025 May 17. doi: 10.1038/s41380-025-03052-7. Online ahead of print. Mol Psychiatry. 2025. PMID: 40382479
Our results confirmed that rs3101339 is a causal variant within 1p31.1 with its risk allele C upregulating NEGR1 expression. To further investigate the consequences of NEGR1 upregulation, we overexpressed NEGR1 in specific region of the mouse brain (including …
Our results confirmed that rs3101339 is a causal variant within 1p31.1 with its risk allele C upregulating NEGR1 expression. To furth …
Major depression-related factor NEGR1 controls salivary secretion in mouse submandibular glands.
Lee J, Kim S, Lee B, Kim YB, Kim KH, Chung G, Lee SJ, Lee S, Sun W, Park HK, Choi SY. Lee J, et al. iScience. 2023 Apr 26;26(5):106773. doi: 10.1016/j.isci.2023.106773. eCollection 2023 May 19. iScience. 2023. PMID: 37216094 Free PMC article.
Here, we studied the function of Neuronal growth regulator 1 (NEGR1) in the salivary gland cells. NEGR1 was also expressed in mouse and human salivary glands. The structure of salivary glands of Negr1 knockout (KO) mice was normal. Negr1 KO mice showed …
Here, we studied the function of Neuronal growth regulator 1 (NEGR1) in the salivary gland cells. NEGR1 was also expressed in …
Depression-Associated Gene Negr1-Fgfr2 Pathway Is Altered by Antidepressant Treatment.
Carboni L, Pischedda F, Piccoli G, Lauria M, Musazzi L, Popoli M, Mathé AA, Domenici E. Carboni L, et al. Cells. 2020 Jul 31;9(8):1818. doi: 10.3390/cells9081818. Cells. 2020. PMID: 32751911 Free PMC article.
The Negr1 gene has been significantly associated with major depression in genetic studies. ...Negr1 and Adam10 were the genes mostly affected by antidepressant treatment, and in opposite directions. ...
The Negr1 gene has been significantly associated with major depression in genetic studies. ...Negr1 and Adam10 were the genes …
Depression-Associated Negr1 Gene-Deficiency Induces Alterations in the Monoaminergic Neurotransmission Enhancing Time-Dependent Sensitization to Amphetamine in Male Mice.
Kaare M, Jayaram M, Jagomäe T, Singh K, Kilk K, Mikheim K, Leevik M, Leidmaa E, Varul J, Nõmm H, Rähn K, Visnapuu T, Plaas M, Lilleväli K, Schäfer MKE, Philips MA, Vasar E. Kaare M, et al. Brain Sci. 2022 Dec 10;12(12):1696. doi: 10.3390/brainsci12121696. Brain Sci. 2022. PMID: 36552158 Free PMC article.
In GWAS studies, the neural adhesion molecule encoding the neuronal growth regulator 1 (NEGR1) gene has been consistently linked with both depression and obesity. Although the linkage between NEGR1 and depression is the strongest, evidence also suggests the involvem …
In GWAS studies, the neural adhesion molecule encoding the neuronal growth regulator 1 (NEGR1) gene has been consistently linked with …
Placental NEGR1 DNA methylation is associated with BMI and neurodevelopment in preschool-age children.
Breton E, Gagné-Ouellet V, Thibeault K, Guérin R, Van Lieshout R, Perron P, Hivert M, Bouchard L. Breton E, et al. Epigenetics. 2020 Mar;15(3):323-335. doi: 10.1080/15592294.2019.1666653. Epub 2019 Sep 23. Epigenetics. 2020. PMID: 31510847 Free PMC article.
DNA methylation (DNAm) might enable foetal adaptations to environmental adversities through important gene loci. NEGR1 is involved in both energy balance and behaviour regulation. The aim of this study was to investigate associations between placental DNAm at the NEGR1 …
DNA methylation (DNAm) might enable foetal adaptations to environmental adversities through important gene loci. NEGR1 is involved in …
miR-576-5p Facilitates Aggressive Cell Behaviors in Colon Adenocarcinoma via Targeting NEGR1.
Jin L, Li X, Zhao Y, Zhu G, Shen W. Jin L, et al. Crit Rev Eukaryot Gene Expr. 2022;32(7):25-33. doi: 10.1615/CritRevEukaryotGeneExpr.2022043160. Crit Rev Eukaryot Gene Expr. 2022. PMID: 36004693
The Cancer Genome Atlas (TCGA) database was introduced to analyze miR-576-5p and NEGR1 messenger RNA (mRNA) expression levels between normal and cancer tissues. miR-576-5p and NEGR1 expression levels in colon adenocarcinoma cells and colon cells were evaluated with …
The Cancer Genome Atlas (TCGA) database was introduced to analyze miR-576-5p and NEGR1 messenger RNA (mRNA) expression levels between …
222 results