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Page 1
ADAM10 sheddase activation is controlled by cell membrane asymmetry.
Bleibaum F, Sommer A, Veit M, Rabe B, Andrä J, Kunzelmann K, Nehls C, Correa W, Gutsmann T, Grötzinger J, Bhakdi S, Reiss K. Bleibaum F, et al. Among authors: nehls c. J Mol Cell Biol. 2019 Dec 23;11(11):979-993. doi: 10.1093/jmcb/mjz008. J Mol Cell Biol. 2019. PMID: 30753537 Free PMC article.
Phosphatidylserine exposure is required for ADAM17 sheddase function.
Sommer A, Kordowski F, Büch J, Maretzky T, Evers A, Andrä J, Düsterhöft S, Michalek M, Lorenzen I, Somasundaram P, Tholey A, Sönnichsen FD, Kunzelmann K, Heinbockel L, Nehls C, Gutsmann T, Grötzinger J, Bhakdi S, Reiss K. Sommer A, et al. Among authors: nehls c. Nat Commun. 2016 May 10;7:11523. doi: 10.1038/ncomms11523. Nat Commun. 2016. PMID: 27161080 Free PMC article.
The human LL-37 peptide exerts antimicrobial activity against Legionella micdadei interacting with membrane phospholipids.
Palusińska-Szysz M, Jurak M, Gisch N, Waldow F, Zehethofer N, Nehls C, Schwudke D, Koper P, Mazur A. Palusińska-Szysz M, et al. Among authors: nehls c. Biochim Biophys Acta Mol Cell Biol Lipids. 2022 Jun;1867(6):159138. doi: 10.1016/j.bbalip.2022.159138. Epub 2022 Feb 26. Biochim Biophys Acta Mol Cell Biol Lipids. 2022. PMID: 35231605
Hit-optimization using target-directed dynamic combinatorial chemistry: development of inhibitors of the anti-infective target 1-deoxy-d-xylulose-5-phosphate synthase.
Jumde RP, Guardigni M, Gierse RM, Alhayek A, Zhu D, Hamid Z, Johannsen S, Elgaher WAM, Neusens PJ, Nehls C, Haupenthal J, Reiling N, Hirsch AKH. Jumde RP, et al. Among authors: nehls c. Chem Sci. 2021 Apr 28;12(22):7775-7785. doi: 10.1039/d1sc00330e. Chem Sci. 2021. PMID: 34168831 Free PMC article.
Cathelicidin and PMB neutralize endotoxins by multifactorial mechanisms including LPS interaction and targeting of host cell membranes.
Schromm AB, Paulowski L, Kaconis Y, Kopp F, Koistinen M, Donoghue A, Keese S, Nehls C, Wernecke J, Garidel P, Sevcsik E, Lohner K, Sanchez-Gomez S, Martinez-de-Tejada G, Brandenburg K, Brameshuber M, Schütz GJ, Andrä J, Gutsmann T. Schromm AB, et al. Among authors: nehls c. Proc Natl Acad Sci U S A. 2021 Jul 6;118(27):e2101721118. doi: 10.1073/pnas.2101721118. Proc Natl Acad Sci U S A. 2021. PMID: 34183393 Free PMC article.
32 results