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Escape from recognition of SARS-CoV-2 Beta variant spike epitopes but overall preservation of T cell immunity.
Riou C, Keeton R, Moyo-Gwete T, Hermanus T, Kgagudi P, Baguma R, Valley-Omar Z, Smith M, Tegally H, Doolabh D, Iranzadeh A, Tyers L, Mutavhatsindi H, Tincho MB, Benede N, Marais G, Chinhoyi LR, Mennen M, Skelem S, du Bruyn E, Stek C; SA-CIN†, de Oliveira T, Williamson C, Moore PL, Wilkinson RJ, Ntusi NAB, Burgers WA, Abrahams F, Ayres F, du Toit E, Goliath RT, Hanekom W, Hardie D, Hsiao NY, Kloverpris H, Korsman S, Lakay F, Lambson B, Leslie A, Makhado Z, Maseko M, Mhlanga D, Naidoo M, Ndhlovu Z, Ngomti A, Oosthuysen B, Ruzive S, Sigal A, Smith T, Valley-Omar Z, van der Westhuizen D, Zvinairo K. Riou C, et al. Among authors: ngomti a. Sci Transl Med. 2021 Dec 21:eabj6824. Online ahead of print. Sci Transl Med. 2021. PMID: 34931886
Prior infection with SARS-CoV-2 boosts and broadens Ad26.COV2.S immunogenicity in a variant-dependent manner.
Keeton R, Richardson SI, Moyo-Gwete T, Hermanus T, Tincho MB, Benede N, Manamela NP, Baguma R, Makhado Z, Ngomti A, Motlou T, Mennen M, Chinhoyi L, Skelem S, Maboreke H, Doolabh D, Iranzadeh A, Otter AD, Brooks T, Noursadeghi M, Moon JC, Grifoni A, Weiskopf D, Sette A, Blackburn J, Hsiao NY, Williamson C, Riou C, Goga A, Garrett N, Bekker LG, Gray G, Ntusi NAB, Moore PL, Burgers WA. Keeton R, et al. Among authors: ngomti a. Cell Host Microbe. 2021 Nov 10;29(11):1611-1619.e5. doi: 10.1016/j.chom.2021.10.003. Epub 2021 Oct 13. Cell Host Microbe. 2021. PMID: 34688376 Free PMC article.