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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1979 1
1980 1
1981 2
2000 1
2001 1
2003 2
2007 1
2008 1
2010 2
2012 1
2013 3
2019 1
2020 2
2021 3
2022 1
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22 results
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Page 1
Discovery of Ketone-Based Covalent Inhibitors of Coronavirus 3CL Proteases for the Potential Therapeutic Treatment of COVID-19.
Hoffman RL, Kania RS, Brothers MA, Davies JF, Ferre RA, Gajiwala KS, He M, Hogan RJ, Kozminski K, Li LY, Lockner JW, Lou J, Marra MT, Mitchell LJ Jr, Murray BW, Nieman JA, Noell S, Planken SP, Rowe T, Ryan K, Smith GJ 3rd, Solowiej JE, Steppan CM, Taggart B. Hoffman RL, et al. Among authors: nieman ja. J Med Chem. 2020 Nov 12;63(21):12725-12747. doi: 10.1021/acs.jmedchem.0c01063. Epub 2020 Oct 15. J Med Chem. 2020. PMID: 33054210 Free PMC article.
Peptidomimetic nitrile warheads as SARS-CoV-2 3CL protease inhibitors.
Bai B, Arutyunova E, Khan MB, Lu J, Joyce MA, Saffran HA, Shields JA, Kandadai AS, Belovodskiy A, Hena M, Vuong W, Lamer T, Young HS, Vederas JC, Tyrrell DL, Lemieux MJ, Nieman JA. Bai B, et al. Among authors: nieman ja. RSC Med Chem. 2021 Aug 20;12(10):1722-1730. doi: 10.1039/d1md00247c. eCollection 2021 Oct 20. RSC Med Chem. 2021. PMID: 34778773
Improved SARS-CoV-2 Mpro inhibitors based on feline antiviral drug GC376: Structural enhancements, increased solubility, and micellar studies.
Vuong W, Fischer C, Khan MB, van Belkum MJ, Lamer T, Willoughby KD, Lu J, Arutyunova E, Joyce MA, Saffran HA, Shields JA, Young HS, Nieman JA, Tyrrell DL, Lemieux MJ, Vederas JC. Vuong W, et al. Among authors: nieman ja. Eur J Med Chem. 2021 Oct 15;222:113584. doi: 10.1016/j.ejmech.2021.113584. Epub 2021 May 30. Eur J Med Chem. 2021. PMID: 34118724 Free PMC article. Review.
Comprehensive in vitro characterization of PD-L1 small molecule inhibitors.
Ganesan A, Ahmed M, Okoye I, Arutyunova E, Babu D, Turnbull WL, Kundu JK, Shields J, Agopsowicz KC, Xu L, Tabana Y, Srivastava N, Zhang G, Moon TC, Belovodskiy A, Hena M, Kandadai AS, Hosseini SN, Hitt M, Walker J, Smylie M, West FG, Siraki AG, Lemieux MJ, Elahi S, Nieman JA, Tyrrell DL, Houghton M, Barakat K. Ganesan A, et al. Among authors: nieman ja. Sci Rep. 2019 Aug 27;9(1):12392. doi: 10.1038/s41598-019-48826-6. Sci Rep. 2019. PMID: 31455818 Free PMC article.
Boron-based phosphodiesterase inhibitors show novel binding of boron to PDE4 bimetal center.
Freund YR, Akama T, Alley MR, Antunes J, Dong C, Jarnagin K, Kimura R, Nieman JA, Maples KR, Plattner JJ, Rock F, Sharma R, Singh R, Sanders V, Zhou Y. Freund YR, et al. Among authors: nieman ja. FEBS Lett. 2012 Sep 21;586(19):3410-4. doi: 10.1016/j.febslet.2012.07.058. Epub 2012 Jul 25. FEBS Lett. 2012. PMID: 22841723 Free article.
Discovery of a novel class of boron-based antibacterials with activity against gram-negative bacteria.
Hernandez V, Crépin T, Palencia A, Cusack S, Akama T, Baker SJ, Bu W, Feng L, Freund YR, Liu L, Meewan M, Mohan M, Mao W, Rock FL, Sexton H, Sheoran A, Zhang Y, Zhang YK, Zhou Y, Nieman JA, Anugula MR, Keramane el M, Savariraj K, Reddy DS, Sharma R, Subedi R, Singh R, O'Leary A, Simon NL, De Marsh PL, Mushtaq S, Warner M, Livermore DM, Alley MR, Plattner JJ. Hernandez V, et al. Among authors: nieman ja. Antimicrob Agents Chemother. 2013 Mar;57(3):1394-403. doi: 10.1128/AAC.02058-12. Epub 2013 Jan 7. Antimicrob Agents Chemother. 2013. PMID: 23295920 Free PMC article.
Bioactivation of flutamide metabolites by human liver microsomes.
Kang P, Dalvie D, Smith E, Zhou S, Deese A, Nieman JA. Kang P, et al. Among authors: nieman ja. Drug Metab Dispos. 2008 Jul;36(7):1425-37. doi: 10.1124/dmd.108.020370. Epub 2008 Apr 14. Drug Metab Dispos. 2008. PMID: 18411402
22 results