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The following term was not found in PubMed: Sabetfar
Page 1
Selective and Potent Molecular Glue Degraders for NIMA-Related Kinase 7.
Chen L, Huang L, Wen W, Zeng P, Wu Y, Han Q, Chen X, Guo Z, Yu H, Lu W, Jiang B. Chen L, et al. Angew Chem Int Ed Engl. 2025 Mar 17;64(12):e202500169. doi: 10.1002/anie.202500169. Epub 2025 Feb 21. Angew Chem Int Ed Engl. 2025. PMID: 39927695
Here, we developed a novel glutarimide analog with a tetrahydroimidazo[1,2-a]pyrazine scaffold that exhibited strong NIMA-related kinase 7 (NEK7) degradation potential. Further optimization led to the identification of LC-04-045 as a leading NEK7 MGD candidate, demonstrati …
Here, we developed a novel glutarimide analog with a tetrahydroimidazo[1,2-a]pyrazine scaffold that exhibited strong NIMA-related kin …
NEK7 phosphorylation amplifies NLRP3 inflammasome activation downstream of potassium efflux and gasdermin D.
Xu J, Zhang L, Duan Y, Sun F, Odeh N, He Y, Núñez G. Xu J, et al. Sci Immunol. 2025 Jan 3;10(103):eadl2993. doi: 10.1126/sciimmunol.adl2993. Epub 2025 Jan 3. Sci Immunol. 2025. PMID: 39752537 Free PMC article.
The NLRP3 inflammasome plays a critical role in innate immunity and inflammatory diseases. NIMA-related kinase 7 (NEK7) is essential for inflammasome activation, and its interaction with NLRP3 is enhanced by K(+) efflux. ...
The NLRP3 inflammasome plays a critical role in innate immunity and inflammatory diseases. NIMA-related kinase 7 (NEK7) is essential …
NEK8, a NIMA-family protein kinase at the core of the ciliary INV complex.
Roig J. Roig J. Cell Commun Signal. 2025 Apr 7;23(1):170. doi: 10.1186/s12964-025-02143-w. Cell Commun Signal. 2025. PMID: 40189576 Free PMC article. Review.
We also review the literature about the pathological consequences of different NEK8 variants in patients of nephronophthisis, renal-hepatic-pancreatic dysplasia and autosomal dominant polycystic kidney disease, three different types of ciliopathies. NEK8 belongs to the NIMA …
We also review the literature about the pathological consequences of different NEK8 variants in patients of nephronophthisis, renal-hepatic- …
Role of NIMA-related kinase 2 in lung cancer: Mechanisms and therapeutic prospects.
Shah D, Joshi M, Patel BM. Shah D, et al. Fundam Clin Pharmacol. 2022 Oct;36(5):766-776. doi: 10.1111/fcp.12777. Epub 2022 Apr 2. Fundam Clin Pharmacol. 2022. PMID: 35338518 Review.
Radiation therapy and surgery also produce recurrence in lung cancer patients; this shows the need to develop novel agents acting on new targets. A never in mitosis (NIMA)-related kinase 2 (NEK2) is a serine/threonine kinase associated with the family of NIMA-relate …
Radiation therapy and surgery also produce recurrence in lung cancer patients; this shows the need to develop novel agents acting on new tar …
In Mitosis You Are Not: The NIMA Family of Kinases in Aspergillus, Yeast, and Mammals.
Bachus S, Graves D, Fulham L, Akkerman N, Stephanson C, Shieh J, Pelka P. Bachus S, et al. Int J Mol Sci. 2022 Apr 6;23(7):4041. doi: 10.3390/ijms23074041. Int J Mol Sci. 2022. PMID: 35409400 Free PMC article. Review.
The Never in mitosis gene A (NIMA) family of serine/threonine kinases is a diverse group of protein kinases implicated in a wide variety of cellular processes, including cilia regulation, microtubule dynamics, mitotic processes, cell growth, and DNA damage response. ...In …
The Never in mitosis gene A (NIMA) family of serine/threonine kinases is a diverse group of protein kinases implicated in a wide vari …
The NIMA kinase: a mitotic regulator in Aspergillus nidulans and vertebrate cells.
Lu KP, Hunter T. Lu KP, et al. Prog Cell Cycle Res. 1995;1:187-205. doi: 10.1007/978-1-4615-1809-9_15. Prog Cell Cycle Res. 1995. PMID: 9552363 Review.
However, in Aspergillus nidulans, activation of CDC2 itself is not sufficient to trigger mitosis if another mitotic protein kinase, NIMA, is not activated. Superficially, NIMA and CDC2 have analogous functions and are regulated in a similar manner. NIMA activ …
However, in Aspergillus nidulans, activation of CDC2 itself is not sufficient to trigger mitosis if another mitotic protein kinase, NIMA …
NEK-mediated barrier regulation.
Barabutis N. Barabutis N. Pulm Pharmacol Ther. 2024 Sep;86:102313. doi: 10.1016/j.pupt.2024.102313. Epub 2024 Jun 21. Pulm Pharmacol Ther. 2024. PMID: 38909830
3,669 results