Chronic restraint stress causes anxiety- and depression-like behaviors, downregulates glucocorticoid receptor expression, and attenuates glutamate release induced by brain-derived neurotrophic factor in the prefrontal cortex.
Prog Neuropsychopharmacol Biol Psychiatry. 2012 Oct 1;39(1):112-9. doi: 10.1016/j.pnpbp.2012.05.018. Epub 2012 Jun 1.
Prog Neuropsychopharmacol Biol Psychiatry. 2012.
PMID: 22664354