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Metabotropic glutamate receptors: physiology, pharmacology, and disease.

Niswender CM, Conn PJ. Niswender CM, et al. Annu Rev Pharmacol Toxicol. 2010;50:295-322. doi: 10.1146/annurev.pharmtox.011008.145533. Annu Rev Pharmacol Toxicol. 2010. PMID: 20055706 Free PMC article. Review.

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Acute restraint stress redirects prefrontal cortex circuit function through mGlu₅ receptor plasticity on somatostatin-expressing interneurons.

Joffe ME, Maksymetz J, Luschinger JR, Dogra S, Ferranti AS, Luessen DJ, Gallinger IM, Xiang Z, Branthwaite H, Melugin PR, Williford KM, Centanni SW, Shields BC, Lindsley CW, Calipari ES, Siciliano CA, Niswender CM, Tadross MR, Winder DG, Conn PJ. Joffe ME, et al. Among authors: niswender cm. Neuron. 2022 Mar 16;110(6):1068-1083.e5. doi: 10.1016/j.neuron.2021.12.027. Epub 2022 Jan 18. Neuron. 2022. PMID: 35045338

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A Coordinated Attack: Rett Syndrome Therapeutic Development.

Gogliotti RG, Niswender CM. Gogliotti RG, et al. Among authors: niswender cm. Trends Pharmacol Sci. 2019 Apr;40(4):233-236. doi: 10.1016/j.tips.2019.02.007. Trends Pharmacol Sci. 2019. PMID: 30905360 Free PMC article. Review.

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Regulation and functional consequences of mGlu₄ RNA editing.

Hofmann CS, Carrington S, Keller AN, Gregory KJ, Niswender CM. Hofmann CS, et al. Among authors: niswender cm. RNA. 2021 Oct;27(10):1220-1240. doi: 10.1261/rna.078729.121. Epub 2021 Jul 8. RNA. 2021. PMID: 34244459

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Identification of a Selective Allosteric Agonist of mGlu₅.

Manka J, Zhou Y, Chun A, Dawson ES, Vinson PN, Niswender CM, Noetzel MJ, Rook JM, Bridges TM, Daniels JS, Jones C, Conn PJ, Lindsley CW, Stauffer SR. Manka J, et al. Among authors: niswender cm. 2011 Dec 16 [updated 2013 Mar 7]. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010–. 2011 Dec 16 [updated 2013 Mar 7]. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010–. PMID: 23762929 Free Books & Documents. Review.

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Development of a Second Generation mGlu₃ NAM Probe.

Wenthur C, Daniels JS, Morrison R, Engers JL, Niswender CM, Conn PJ, Lindsley CW. Wenthur C, et al. Among authors: niswender cm. 2012 Dec 10 [updated 2013 Mar 22]. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010–. 2012 Dec 10 [updated 2013 Mar 22]. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010–. PMID: 23885366 Free Books & Documents. Review.

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mGluR7's lucky number.

Conn PJ, Niswender CM. Conn PJ, et al. Among authors: niswender cm. Proc Natl Acad Sci U S A. 2006 Jan 10;103(2):251-2. doi: 10.1073/pnas.0510051103. Epub 2006 Jan 3. Proc Natl Acad Sci U S A. 2006. PMID: 16407154 Free PMC article. No abstract available.

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Discovery of VU6028418: A Highly Selective and Orally Bioavailable M₄ Muscarinic Acetylcholine Receptor Antagonist.

Spock M, Carter TR, Bollinger KA, Han C, Baker LA, Rodriguez AL, Peng L, Dickerson JW, Qi A, Rook JM, O'Neill JC, Watson KJ, Chang S, Bridges TM, Engers JL, Engers DW, Niswender CM, Conn PJ, Lindsley CW, Bender AM. Spock M, et al. Among authors: niswender cm. ACS Med Chem Lett. 2021 Aug 2;12(8):1342-1349. doi: 10.1021/acsmedchemlett.1c00363. eCollection 2021 Aug 12. ACS Med Chem Lett. 2021. PMID: 34413964

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Discovery of structurally distinct tricyclic M₄ positive allosteric modulator (PAM) chemotypes - Part 2.

Long MF, Capstick RA, Spearing PK, Engers JL, Gregro AR, Bollinger SR, Chang S, Luscombe VB, Rodriguez AL, Cho HP, Niswender CM, Bridges TM, Conn PJ, Lindsley CW, Engers DW, Temple KJ. Long MF, et al. Among authors: niswender cm. Bioorg Med Chem Lett. 2021 Dec 1;53:128416. doi: 10.1016/j.bmcl.2021.128416. Epub 2021 Oct 26. Bioorg Med Chem Lett. 2021. PMID: 34710625

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A GRM7 mutation associated with developmental delay reduces mGlu7 expression and produces neurological phenotypes.

Fisher NM, AlHashim A, Buch AB, Badivuku H, Samman MM, Weiss KM, Cestero GI, Does MD, Rook JM, Lindsley CW, Conn PJ, Gogliotti RG, Niswender CM. Fisher NM, et al. Among authors: niswender cm. JCI Insight. 2021 Feb 22;6(4):e143324. doi: 10.1172/jci.insight.143324. JCI Insight. 2021. PMID: 33476302 Free PMC article.

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