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Identification of a rapidly-spreading triple mutant for high-level metabolic insecticide resistance in Anopheles gambiae provides a real-time molecular diagnostic for antimalarial intervention deployment.
Njoroge H, Van't Hof A, Oruni A, Pipini D, Nagi SC, Lynd A, Lucas ER, Tomlinson S, Grau-Bove X, McDermott D, Wat'senga FT, Manzambi EZ, Agossa FR, Mokuba A, Irish S, Kabula B, Mbogo C, Bargul J, Paine MJI, Weetman D, Donnelly MJ. Njoroge H, et al. Mol Ecol. 2022 Aug;31(16):4307-4318. doi: 10.1111/mec.16591. Epub 2022 Jul 12. Mol Ecol. 2022. PMID: 35775282 Free PMC article.
A high throughput multi-locus insecticide resistance marker panel for tracking resistance emergence and spread in Anopheles gambiae.
Lucas ER, Rockett KA, Lynd A, Essandoh J, Grisales N, Kemei B, Njoroge H, Hubbart C, Rippon EJ, Morgan J, Van't Hof AE, Ochomo EO, Kwiatkowski DP, Weetman D, Donnelly MJ. Lucas ER, et al. Among authors: njoroge h. Sci Rep. 2019 Sep 16;9(1):13335. doi: 10.1038/s41598-019-49892-6. Sci Rep. 2019. PMID: 31527637 Free PMC article.
Rapid high throughput SYBR green assay for identifying the malaria vectors Anopheles arabiensis, Anopheles coluzzii and Anopheles gambiae s.s. Giles.
Chabi J, Van't Hof A, N'dri LK, Datsomor A, Okyere D, Njoroge H, Pipini D, Hadi MP, de Souza DK, Suzuki T, Dadzie SK, Jamet HP. Chabi J, et al. Among authors: njoroge h. PLoS One. 2019 Apr 19;14(4):e0215669. doi: 10.1371/journal.pone.0215669. eCollection 2019. PLoS One. 2019. PMID: 31002694 Free PMC article.
Pyrethroid resistance and gene expression profile of a new resistant An. gambiae colony from Uganda reveals multiple resistance mechanisms and overexpression of Glutathione-S-Transferases linked to survival of PBO-pyrethroid combination.
Oruni A, Lynd A, Njoroge H, Onyige I, Van't Hof AE, Matovu E, Donnelly MJ. Oruni A, et al. Among authors: njoroge h. Wellcome Open Res. 2024 Apr 29;9:13. doi: 10.12688/wellcomeopenres.19404.2. eCollection 2024. Wellcome Open Res. 2024. PMID: 38813466 Free PMC article.