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170 results

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Page 1
NLRC3 deficiency promotes hypoxia-induced pulmonary hypertension development via IKK/NF-kappaB p65/HIF-1alpha pathway.
Maimaitiaili N, Zeng Y, Ju P, Zhakeer G, E G, Yao H, Shi Y, Zhai M, Zhuang J, Peng W, Zhuoga D, Yu Q. Maimaitiaili N, et al. Exp Cell Res. 2023 Oct 15;431(2):113755. doi: 10.1016/j.yexcr.2023.113755. Epub 2023 Aug 14. Exp Cell Res. 2023. PMID: 37586455 Free article. Review.
Immunohistochemistry and immunofluorescence showed that NLRC3 was downregulated and was mainly co-localized with the smooth muscle cells of the pulmonary vessels in HAPH patients. Besides, we found that NLRC3 was also expressed in endothelial cells in HAPH patients …
Immunohistochemistry and immunofluorescence showed that NLRC3 was downregulated and was mainly co-localized with the smooth muscle ce …
NLRC3 expression in macrophage impairs glycolysis and host immune defense by modulating the NF-kappaB-NFAT5 complex during septic immunosuppression.
Xu J, Gao C, He Y, Fang X, Sun D, Peng Z, Xiao H, Sun M, Zhang P, Zhou T, Yang X, Yu Y, Li R, Zou X, Shu H, Qiu Y, Zhou X, Yuan S, Yao S, Shang Y. Xu J, et al. Mol Ther. 2023 Jan 4;31(1):154-173. doi: 10.1016/j.ymthe.2022.08.023. Epub 2022 Sep 6. Mol Ther. 2023. PMID: 36068919 Free PMC article.
Myeloid-specific NLRC3 deletion improved macrophage glycolysis and sepsis-induced immunosuppression. Mechanistically, NLRC3 inhibits nuclear factor (NF)-kappaB p65 binding to nuclear factor of activated T cells 5 (NFAT5), which further controls the expression of gly …
Myeloid-specific NLRC3 deletion improved macrophage glycolysis and sepsis-induced immunosuppression. Mechanistically, NLRC3 in …
Negative regulator NLRC3: Its potential role and regulatory mechanism in immune response and immune-related diseases.
Sun D, Xu J, Zhang W, Song C, Gao C, He Y, Shang Y. Sun D, et al. Front Immunol. 2022 Oct 20;13:1012459. doi: 10.3389/fimmu.2022.1012459. eCollection 2022. Front Immunol. 2022. PMID: 36341336 Free PMC article. Review.
In macrophages, NLRC3 inhibits the activation of the NF-kappaB signaling pathway, the STING/TBK1 signaling pathway, and the formation of the inflammasome. ...In this review, we elaborate the potential roles of NLRC3 from several different levels, include molecular m …
In macrophages, NLRC3 inhibits the activation of the NF-kappaB signaling pathway, the STING/TBK1 signaling pathway, and the formation …
Overview of the anti-inflammatory function of the innate immune sensor NLRC3.
Zhao Y, Li R. Zhao Y, et al. Mol Immunol. 2023 Jan;153:36-41. doi: 10.1016/j.molimm.2022.11.014. Epub 2022 Nov 17. Mol Immunol. 2023. PMID: 36403432 Review.
NLRC3 is closely related to the development of tumors, infectious diseases, autoimmune diseases, and AD. These diseases might be treated effectively by regulating the expression of NLRC3....
NLRC3 is closely related to the development of tumors, infectious diseases, autoimmune diseases, and AD. These diseases might be trea …
NLRC3-like 1 inhibits NOD1-RIPK2 pathway via targeting RIPK2.
Fang H, Wu XM, Hu YW, Song YJ, Zhang J, Chang MX. Fang H, et al. Dev Comp Immunol. 2020 Nov;112:103769. doi: 10.1016/j.dci.2020.103769. Epub 2020 Jul 4. Dev Comp Immunol. 2020. PMID: 32634524
Both NLRC3 and NOD1 belong to regulatory NLR subfamily based on their best-characterized function. ...In teleosts, multiple NLRC3-like genes were identified through transcriptome sequencing. However, the functions of many NLRC3-like genes, especially the fish …
Both NLRC3 and NOD1 belong to regulatory NLR subfamily based on their best-characterized function. ...In teleosts, multiple NLRC3 …
Mechanism and Application Prospects of NLRC3 Regulating cGAS-STING Pathway in Lung Cancer Immunotherapy.
Wang Q, Ren Z, Zhao J, Zheng T, Tong L, Liu J, Dai Z, Tang S. Wang Q, et al. Int J Med Sci. 2024 Oct 7;21(13):2613-2622. doi: 10.7150/ijms.102328. eCollection 2024. Int J Med Sci. 2024. PMID: 39439455 Free PMC article. Review.
The inhibition of NLRC3 has been found to augment the activity of the aforementioned pathway, thereby enhancing the anti-tumor immune response. ...The development of pharmaceutical interventions and gene therapy strategies targeting NLRC3 presents a promising avenue …
The inhibition of NLRC3 has been found to augment the activity of the aforementioned pathway, thereby enhancing the anti-tumor immune …
NLRC3 deficiency promotes cutaneous wound healing due to the inhibition of p53 signaling.
Qin Y, Wu K, Zhang Z, Pan R, Lin Z, Zhang W, Huang S, Dai J, Huang R, Gong S, Lin H, Chong S, Lu L, Lu X. Qin Y, et al. Biochim Biophys Acta Mol Basis Dis. 2022 Nov 1;1868(11):166518. doi: 10.1016/j.bbadis.2022.166518. Epub 2022 Aug 10. Biochim Biophys Acta Mol Basis Dis. 2022. PMID: 35963285 Free article.
However, the function of NLRC3 in wound healing remains unclear. Here, we investigated the function of NLRC3 in acute cutaneous wound healing using Nlrc3 gene knockout (Nlrc3(-/-)) mice. ...Mechanistically, we uncovered novel crosstalk between NLRC3 …
However, the function of NLRC3 in wound healing remains unclear. Here, we investigated the function of NLRC3 in acute cutaneou …
NLRC3 inhibits PDGF-induced PASMCs proliferation via PI3K-mTOR pathway.
Zha LH, Zhou J, Tan Y, Guo S, Zhang MQ, Li S, Yan P, Yu ZX. Zha LH, et al. J Cell Physiol. 2020 Dec;235(12):9557-9567. doi: 10.1002/jcp.29763. Epub 2020 May 7. J Cell Physiol. 2020. PMID: 32383265
Few studies about nucleotide-oligomerization domain-like receptor subfamily C3 (NLRC3) in PASMCs have been conducted. This research aimed to investigate the role of NLRC3 on platelet-derived growth factor (PDGF)-induced proliferation of pulmonary artery smooth muscl …
Few studies about nucleotide-oligomerization domain-like receptor subfamily C3 (NLRC3) in PASMCs have been conducted. This research a …
Nlrc3 Knockout Mice Showed Renal Pathological Changes After HTNV Infection.
Ma R, Zhang X, Shu J, Liu Z, Sun W, Hou S, Lv Y, Ying Q, Wang F, Jin X, Liu R, Wu X. Ma R, et al. Front Immunol. 2021 Jul 16;12:692509. doi: 10.3389/fimmu.2021.692509. eCollection 2021. Front Immunol. 2021. PMID: 34335602 Free PMC article.
The development of well-characterized animal models of HFRS could accelerate the testing of vaccine candidates and therapeutic agents and provide a useful tool for studying the pathogenesis of HFRS. Because NLRC3 has multiple immunoregulatory roles, we investigated the sus …
The development of well-characterized animal models of HFRS could accelerate the testing of vaccine candidates and therapeutic agents and pr …
Nlrc3 signaling is indispensable for hematopoietic stem cell emergence via Notch signaling in vertebrates.
Cai S, Li H, Tie R, Shan W, Luo Q, Wang S, Feng C, Chen H, Zhang M, Xu Y, Li X, Chen M, Lu J, Qian P, Huang H. Cai S, et al. Nat Commun. 2024 Jan 3;15(1):226. doi: 10.1038/s41467-023-44251-6. Nat Commun. 2024. PMID: 38172511 Free PMC article.
Mechanistically, nlrc3 activates the Notch pathway and the downstream gene of Notch hey1. Furthermore, NF-kB signaling acts upstream of nlrc3 to enhance its transcriptional activity. Finally, we find that Nlrc3 signaling is conserved in the regulation of muri …
Mechanistically, nlrc3 activates the Notch pathway and the downstream gene of Notch hey1. Furthermore, NF-kB signaling acts upstream …
170 results