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82 results

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Page 1
Activation of the NLRP1B inflammasome by caspase-8.
Meade JJ, Stuart S, Neiman-Zenevich J, Krustev C, Girardin SE, Mogridge J. Meade JJ, et al. Commun Biol. 2024 Sep 17;7(1):1164. doi: 10.1038/s42003-024-06882-3. Commun Biol. 2024. PMID: 39289441 Free PMC article.
Caspase-8 activity, induced downstream of this TLR4 pathway or through a distinct TNF receptor pathway, causes cleavage and activation of NLRP1B, which facilitates the maturation of both pro-caspase-1 and pro-caspase-8. Thus, our findings indicate that caspase-8 and NLR …
Caspase-8 activity, induced downstream of this TLR4 pathway or through a distinct TNF receptor pathway, causes cleavage and activation of …
N-terminal degradation activates the NLRP1B inflammasome.
Chui AJ, Okondo MC, Rao SD, Gai K, Griswold AR, Johnson DC, Ball DP, Taabazuing CY, Orth EL, Vittimberga BA, Bachovchin DA. Chui AJ, et al. Science. 2019 Apr 5;364(6435):82-85. doi: 10.1126/science.aau1208. Epub 2019 Mar 14. Science. 2019. PMID: 30872531 Free PMC article.
The anthrax lethal factor metalloprotease and small-molecule DPP8/9 inhibitors both activate the NLRP1B inflammasome, but the molecular mechanism of NLRP1B activation is unknown. In this study, we used genome-wide CRISPR-Cas9 knockout screens to identify genes requi …
The anthrax lethal factor metalloprotease and small-molecule DPP8/9 inhibitors both activate the NLRP1B inflammasome, but the molecul …
NLRP1B allele 2 does not respond to Val-boro-Pro (VbP) in intestinal epithelial cells.
Mazzone RJ, Winsor NJ, Li LY, Barry KT, Ranger A, Goyal S, Meade JJ, Bruce J, Philpott DJ, Mogridge J, Girardin SE. Mazzone RJ, et al. Microbes Infect. 2024 Nov-Dec;26(8):105398. doi: 10.1016/j.micinf.2024.105398. Epub 2024 Jul 22. Microbes Infect. 2024. PMID: 39047896 Free article.
Here, we show that Nlrp1b allele 2 is expressed in ileal and colonic organoids derived for C57BL/6J mice, while the related gene Nlrp1a was not expressed. Nlrp1b was upregulated by interleukin-13 in organoids and by the protozoan Tritrichomonas muris in vivo, sugges …
Here, we show that Nlrp1b allele 2 is expressed in ileal and colonic organoids derived for C57BL/6J mice, while the related gene Nlrp …
NLRP1B and NLRP3 Control the Host Response following Colonization with the Commensal Protist Tritrichomonas musculis.
Chiaranunt P, Burrows K, Ngai L, Cao EY, Liang H, Tai SL, Streutker CJ, Girardin SE, Mortha A. Chiaranunt P, et al. J Immunol. 2022 Apr 1;208(7):1782-1789. doi: 10.4049/jimmunol.2100802. Epub 2022 Mar 7. J Immunol. 2022. PMID: 35256512
In this study, we report that colonization with T. musculis results in an increase in luminal extracellular ATP that is followed by increased caspase activity, higher cell death, elevated levels of IL-1beta, and increased numbers of IL-18 receptor-expressing Th1 and Th17 cells in …
In this study, we report that colonization with T. musculis results in an increase in luminal extracellular ATP that is followed by increase …
Functional degradation: A mechanism of NLRP1 inflammasome activation by diverse pathogen enzymes.
Sandstrom A, Mitchell PS, Goers L, Mu EW, Lesser CF, Vance RE. Sandstrom A, et al. Science. 2019 Apr 5;364(6435):eaau1330. doi: 10.1126/science.aau1330. Epub 2019 Mar 14. Science. 2019. PMID: 30872533 Free PMC article.
Proteasome-mediated degradation of NLRP1B is both necessary and sufficient for NLRP1B activation. Consistent with our functional degradation model, we identify IpaH7.8, a Shigella flexneri ubiquitin ligase secreted effector, as an enzyme that induces NLRP1B d …
Proteasome-mediated degradation of NLRP1B is both necessary and sufficient for NLRP1B activation. Consistent with our function …
UVB-Induced Skin Autoinflammation Due to Nlrp1b Mutation and Its Inhibition by Anti-IL-1beta Antibody.
Murase Y, Takeichi T, Koseki J, Miyasaka Y, Muro Y, Ohno T, Shimamura T, Akiyama M. Murase Y, et al. Front Immunol. 2022 Jun 17;13:876390. doi: 10.3389/fimmu.2022.876390. eCollection 2022. Front Immunol. 2022. PMID: 35784371 Free PMC article.
NLRP1 hyperactivity has been reported to cause inherited autoinflammatory diseases including familial keratosis lichenoides chronica and NLRP1-associated autoinflammation with arthritis and dyskeratosis. We generated Nlrp1b (the mouse homologue of human NLRP1) gain-of-func …
NLRP1 hyperactivity has been reported to cause inherited autoinflammatory diseases including familial keratosis lichenoides chronica and NLR …
Listeria monocytogenes and Shigella flexneri Activate the NLRP1B Inflammasome.
Neiman-Zenevich J, Stuart S, Abdel-Nour M, Girardin SE, Mogridge J. Neiman-Zenevich J, et al. Infect Immun. 2017 Oct 18;85(11):e00338-17. doi: 10.1128/IAI.00338-17. Print 2017 Nov. Infect Immun. 2017. PMID: 28808162 Free PMC article.
Here we addressed whether these pathogens activate the NLRP1B inflammasome. We found that Listeria infection activated the NLRP1B inflammasome in a reconstituted fibroblast model. ...Infections of either Listeria or Shigella activated NLRP1B in the RAW264.7 m …
Here we addressed whether these pathogens activate the NLRP1B inflammasome. We found that Listeria infection activated the NLRP1B …
The N-end rule ubiquitin ligase UBR2 mediates NLRP1B inflammasome activation by anthrax lethal toxin.
Xu H, Shi J, Gao H, Liu Y, Yang Z, Shao F, Dong N. Xu H, et al. EMBO J. 2019 Jul 1;38(13):e101996. doi: 10.15252/embj.2019101996. Epub 2019 May 6. EMBO J. 2019. PMID: 31268597 Free PMC article.
UBR2, an E3 ubiquitin ligase of the N-end rule degradation pathway, was found to be required for LT-induced NLRP1B inflammasome activation. LT is known to cleave NLRP1B after Lys44. The cleaved NLRP1B, bearing an N-terminal leucine, was targeted by UBR2-media …
UBR2, an E3 ubiquitin ligase of the N-end rule degradation pathway, was found to be required for LT-induced NLRP1B inflammasome activ …
DPP8/DPP9 inhibition elicits canonical Nlrp1b inflammasome hallmarks in murine macrophages.
de Vasconcelos NM, Vliegen G, Gonçalves A, De Hert E, Martín-Pérez R, Van Opdenbosch N, Jallapally A, Geiss-Friedlander R, Lambeir AM, Augustyns K, Van Der Veken P, De Meester I, Lamkanfi M. de Vasconcelos NM, et al. Life Sci Alliance. 2019 Feb 4;2(1):e201900313. doi: 10.26508/lsa.201900313. Print 2019 Feb. Life Sci Alliance. 2019. PMID: 30718379 Free PMC article.
Here, we show that DPP8/DPP9 inhibition in macrophages that express a Bacillus anthracis lethal toxin (LeTx)-sensitive Nlrp1b allele triggered significantly accelerated pyroptosis concomitant with caspase-1 maturation, ASC speck assembly, and secretion of mature IL-1beta a …
Here, we show that DPP8/DPP9 inhibition in macrophages that express a Bacillus anthracis lethal toxin (LeTx)-sensitive Nlrp1b allele …
82 results