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580 results

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Page 1
NSD1: A Lysine Methyltransferase between Developmental Disorders and Cancer.
Tauchmann S, Schwaller J. Tauchmann S, et al. Life (Basel). 2021 Aug 25;11(9):877. doi: 10.3390/life11090877. Life (Basel). 2021. PMID: 34575025 Free PMC article. Review.
Recurrent epigenomic alterations associated with multiple human pathologies have increased the interest in the nuclear receptor binding SET domain protein 1 (NSD1) lysine methyltransferase. Here, we review the current knowledge about the biochemistry, cellular function and …
Recurrent epigenomic alterations associated with multiple human pathologies have increased the interest in the nuclear receptor binding SET …
NSD1 mediates antagonism between SWI/SNF and polycomb complexes and is required for transcriptional activation upon EZH2 inhibition.
Drosos Y, Myers JA, Xu B, Mathias KM, Beane EC, Radko-Juettner S, Mobley RJ, Larsen ME, Piccioni F, Ma X, Low J, Hansen BS, Peters ST, Bhanu NV, Dhanda SK, Chen T, Upadhyaya SA, Pruett-Miller SM, Root DE, Garcia BA, Partridge JF, Roberts CWM. Drosos Y, et al. Mol Cell. 2022 Jul 7;82(13):2472-2489.e8. doi: 10.1016/j.molcel.2022.04.015. Epub 2022 May 9. Mol Cell. 2022. PMID: 35537449 Free PMC article.
We found that loss of the H3K36 methyltransferase NSD1 caused resistance to EZH2 inhibition. We show that NSD1 antagonizes polycomb via cooperation with SWI/SNF and identify co-occurrence of NSD1 inactivation in SWI/SNF-defective cancers, indicating in vivo r …
We found that loss of the H3K36 methyltransferase NSD1 caused resistance to EZH2 inhibition. We show that NSD1 antagonizes pol …
The role of NSD1, NSD2, and NSD3 histone methyltransferases in solid tumors.
Topchu I, Pangeni RP, Bychkov I, Miller SA, Izumchenko E, Yu J, Golemis E, Karanicolas J, Boumber Y. Topchu I, et al. Cell Mol Life Sci. 2022 May 9;79(6):285. doi: 10.1007/s00018-022-04321-2. Cell Mol Life Sci. 2022. PMID: 35532818 Free PMC article. Review.
NSD1, NSD2, and NSD3 constitute the nuclear receptor-binding SET Domain (NSD) family of histone 3 lysine 36 (H3K36) methyltransferases. ...
NSD1, NSD2, and NSD3 constitute the nuclear receptor-binding SET Domain (NSD) family of histone 3 lysine 36 (H3K36) methyltransferase …
Chromatin regulation of transcriptional enhancers and cell fate by the Sotos syndrome gene NSD1.
Sun Z, Lin Y, Islam MT, Koche R, Hedehus L, Liu D, Huang C, Vierbuchen T, Sawyers CL, Helin K. Sun Z, et al. Mol Cell. 2023 Jul 20;83(14):2398-2416.e12. doi: 10.1016/j.molcel.2023.06.007. Epub 2023 Jul 3. Mol Cell. 2023. PMID: 37402365 Free PMC article.
Despite the impacts of H3K36me2 on H3K27me3 and DNA methylation, the direct role of NSD1 in transcriptional regulation remains largely unknown. Here, we show that NSD1 and H3K36me2 are enriched at cis-regulatory elements, particularly enhancers. ...By combining acut …
Despite the impacts of H3K36me2 on H3K27me3 and DNA methylation, the direct role of NSD1 in transcriptional regulation remains largel …
Role of NSD1 as potential therapeutic target in tumor.
Yang C, Wang K, Liang Q, Tian TT, Zhong Z. Yang C, et al. Pharmacol Res. 2021 Nov;173:105888. doi: 10.1016/j.phrs.2021.105888. Epub 2021 Sep 16. Pharmacol Res. 2021. PMID: 34536546 Review.
Therefore, targeting NSD1 may be a potential strategy for tumor therapy. An in-depth study of the structure and biological activities of NSD1 sets the groundwork for improving tumor therapy and creating NSD1 inhibitors. This article emphasizes the role of …
Therefore, targeting NSD1 may be a potential strategy for tumor therapy. An in-depth study of the structure and biological activities …
Genotype-phenotype associations in Sotos syndrome: an analysis of 266 individuals with NSD1 aberrations.
Tatton-Brown K, Douglas J, Coleman K, Baujat G, Cole TR, Das S, Horn D, Hughes HE, Temple IK, Faravelli F, Waggoner D, Turkmen S, Cormier-Daire V, Irrthum A, Rahman N; Childhood Overgrowth Collaboration. Tatton-Brown K, et al. Am J Hum Genet. 2005 Aug;77(2):193-204. doi: 10.1086/432082. Epub 2005 Jun 7. Am J Hum Genet. 2005. PMID: 15942875 Free PMC article.
We identified 266 individuals with intragenic NSD1 mutations or 5q35 microdeletions encompassing NSD1 (referred to as "NSD1-positive individuals"), through analyses of 530 subjects with diverse phenotypes. ...Sotos syndrome was clinically diagnosed in 99% of …
We identified 266 individuals with intragenic NSD1 mutations or 5q35 microdeletions encompassing NSD1 (referred to as "NSD1 …
Lysine Methyltransferase NSD1 and Cancers: Any Role in Melanoma?
Krossa I, Strub T, Aplin AE, Ballotti R, Bertolotto C. Krossa I, et al. Cancers (Basel). 2022 Oct 5;14(19):4865. doi: 10.3390/cancers14194865. Cancers (Basel). 2022. PMID: 36230787 Free PMC article. Review.
We then report the role of NSD1 in triggering tumor suppressive or promoter functions according to the tissue context and we discuss the role of NSD1 in melanoma. Finally, we examine the ongoing efforts to target NSD1 signaling in cancers....
We then report the role of NSD1 in triggering tumor suppressive or promoter functions according to the tissue context and we discuss …
H3K36 methyltransferase NSD1 protects against osteoarthritis through regulating chondrocyte differentiation and cartilage homeostasis.
Shao R, Suo J, Zhang Z, Kong M, Ma Y, Wen Y, Liu M, Zhuang L, Ge K, Bi Q, Zhang C, Zou W. Shao R, et al. Cell Death Differ. 2024 Jan;31(1):106-118. doi: 10.1038/s41418-023-01244-8. Epub 2023 Nov 27. Cell Death Differ. 2024. PMID: 38012390
Immunostaining results showed decreased anabolic and increased catabolic activities in Nsd1(Prrx1-Cre) mice, along with decreased chondrogenic differentiation. Transcriptome and ChIP-seq data revealed that Osr2 was a key factor affected by Nsd1. Intra-articular deli …
Immunostaining results showed decreased anabolic and increased catabolic activities in Nsd1(Prrx1-Cre) mice, along with decreased cho …
NSD1 deposits histone H3 lysine 36 dimethylation to pattern non-CG DNA methylation in neurons.
Hamagami N, Wu DY, Clemens AW, Nettles SA, Li A, Gabel HW. Hamagami N, et al. Mol Cell. 2023 May 4;83(9):1412-1428.e7. doi: 10.1016/j.molcel.2023.04.001. Epub 2023 Apr 24. Mol Cell. 2023. PMID: 37098340 Free PMC article.
We find that brain-specific deletion of NSD1 causes altered DNA methylation that overlaps with DNMT3A disorder models to drive convergent dysregulation of key neuronal genes that may underlie shared phenotypes in NSD1- and DNMT3A-associated NDDs. Our findings indica …
We find that brain-specific deletion of NSD1 causes altered DNA methylation that overlaps with DNMT3A disorder models to drive conver …
Histone methylation mediated by NSD1 is required for the establishment and maintenance of neuronal identities.
Zheng Y, Zhao C, Song Q, Xu L, Zhang B, Hu G, Kong X, Li S, Li X, Shen Y, Zhuang L, Wu M, Liu Y, Zhou Y. Zheng Y, et al. Cell Rep. 2023 Dec 26;42(12):113496. doi: 10.1016/j.celrep.2023.113496. Epub 2023 Nov 22. Cell Rep. 2023. PMID: 37995181 Free article.
Nsd1 conditional knockout mice displayed defects in spatial memory, motor learning, and coordination, resembling patients with the Sotos syndrome carrying NSD1 mutations. ...Together, H3K36me2 mediated by NSD1 is required for the establishment and maintenance …
Nsd1 conditional knockout mice displayed defects in spatial memory, motor learning, and coordination, resembling patients with the So …
580 results