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80 results

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Page 1
NSMF promotes the replication stress-induced DNA damage response for genome maintenance.
Ju MK, Shin KJ, Lee JR, Khim KW, A Lee E, Ra JS, Kim BG, Jo HS, Yoon JH, Kim TM, Myung K, Choi JH, Kim H, Chae YC. Ju MK, et al. Nucleic Acids Res. 2021 Jun 4;49(10):5605-5622. doi: 10.1093/nar/gkab311. Nucleic Acids Res. 2021. PMID: 33963872 Free PMC article.
Consistently, NSMF knockout mice exhibited increased genomic instability and hypersensitivity to genotoxic stress. NSMF deficiency in human and mouse cells also caused increased chromosomal instability. ...
Consistently, NSMF knockout mice exhibited increased genomic instability and hypersensitivity to genotoxic stress. NSMF defici …
Isolated Gonadotropin-Releasing Hormone (GnRH) Deficiency.
Balasubramanian R, Crowley WF Jr. Balasubramanian R, et al. 2007 May 23 [updated 2022 May 12]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. 2007 May 23 [updated 2022 May 12]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. PMID: 20301509 Free Books & Documents. Review.
Investigation of subfertility in the female Nsmf knockout mouse.
Louden ED, Dougherty MP, Chorich LP, Eroglu A, Layman LC. Louden ED, et al. F S Sci. 2023 Nov;4(4):286-293. doi: 10.1016/j.xfss.2023.07.003. Epub 2023 Jul 27. F S Sci. 2023. PMID: 37516276
OBJECTIVE: To study if a pituitary or ovarian defect contributes to subfertility of the female Nsmf knockout (KO) mouse, an animal model of the hypogonadotropic hypogonadism gene NSMF. ...Western blot demonstrated NSMF protein expression in the ovary of WT mi …
OBJECTIVE: To study if a pituitary or ovarian defect contributes to subfertility of the female Nsmf knockout (KO) mouse, an animal mo …
A Jacob/nsmf gene knockout does not protect against acute hypoxia- and NMDA-induced excitotoxic cell death.
Gomes GM, Bär J, Karpova A, Kreutz MR. Gomes GM, et al. Mol Brain. 2023 Feb 11;16(1):23. doi: 10.1186/s13041-023-01012-2. Mol Brain. 2023. PMID: 36774487 Free PMC article.
Given that extrasynaptic activity is also involved in acute excitotoxicity, like in stroke, we asked whether nsmf gene knockout will also protect against acute insults, like oxygen and glucose deprivation and excitotoxic NMDA stimulation. nsmf is the gene that encod …
Given that extrasynaptic activity is also involved in acute excitotoxicity, like in stroke, we asked whether nsmf gene knockout will …
Alteration of replication protein A binding mode on single-stranded DNA by NSMF potentiates RPA phosphorylation by ATR kinase.
Kang Y, Han YG, Khim KW, Choi WG, Ju MK, Park K, Shin KJ, Chae YC, Choi JH, Kim H, Lee JY. Kang Y, et al. Nucleic Acids Res. 2023 Aug 25;51(15):7936-7950. doi: 10.1093/nar/gkad543. Nucleic Acids Res. 2023. PMID: 37378431 Free PMC article.
However, how NSMF enhances ATR-mediated RPA32 phosphorylation remains elusive. Here, we demonstrate that NSMF colocalizes and physically interacts with RPA at DNA damage sites in vivo and in vitro. ...Our findings provide new mechanistic insight into how NSMF …
However, how NSMF enhances ATR-mediated RPA32 phosphorylation remains elusive. Here, we demonstrate that NSMF colocalizes and …
A Jacob/Nsmf Gene Knockout Results in Hippocampal Dysplasia and Impaired BDNF Signaling in Dendritogenesis.
Spilker C, Nullmeier S, Grochowska KM, Schumacher A, Butnaru I, Macharadze T, Gomes GM, Yuanxiang P, Bayraktar G, Rodenstein C, Geiseler C, Kolodziej A, Lopez-Rojas J, Montag D, Angenstein F, Bär J, D'Hanis W, Roskoden T, Mikhaylova M, Budinger E, Ohl FW, Stork O, Zenclussen AC, Karpova A, Schwegler H, Kreutz MR. Spilker C, et al. PLoS Genet. 2016 Mar 15;12(3):e1005907. doi: 10.1371/journal.pgen.1005907. eCollection 2016 Mar. PLoS Genet. 2016. PMID: 26977770 Free PMC article.
Jacob, the protein encoded by the Nsmf gene, is involved in synapto-nuclear signaling and docks an N-Methyl-D-Aspartate receptor (NMDAR)-derived signalosome to nuclear target sites like the transcription factor cAMP-response-element-binding protein (CREB). Several reports …
Jacob, the protein encoded by the Nsmf gene, is involved in synapto-nuclear signaling and docks an N-Methyl-D-Aspartate receptor (NMD …
N-methyl D-aspartate receptor synaptonuclear signaling and neuronal migration factor (Nsmf) plays a novel role in myoblast proliferation.
Moon HY. Moon HY. In Vitro Cell Dev Biol Anim. 2015 Jan;51(1):79-84. doi: 10.1007/s11626-014-9811-9. Epub 2014 Sep 24. In Vitro Cell Dev Biol Anim. 2015. PMID: 25248434
Knockdown of Nsmf in myocytes by siRNA did not affect the myocyte differentiation marker myogenin. However, flow cytometry showed that the proliferation rate of the Nsmf-knockdown cells was reduced compared to the control cells. Therefore, our results indicate that …
Knockdown of Nsmf in myocytes by siRNA did not affect the myocyte differentiation marker myogenin. However, flow cytometry showed tha …
What do we learn from the murine Jacob/Nsmf gene knockout for human disease?
Spilker C, Grochowska KM, Kreutz MR. Spilker C, et al. Rare Dis. 2016 Sep 30;4(1):e1241361. doi: 10.1080/21675511.2016.1241361. eCollection 2016. Rare Dis. 2016. PMID: 27803842 Free PMC article.
Mutations in the NSMF gene have been related to Kallmann syndrome. Conflicting results have been reported on the subcellular localization of Jacob/NELF, the protein encoded by the NSMF gene. ...A recent publication casts doubts on a major role of Jacob/NELF in Kallm …
Mutations in the NSMF gene have been related to Kallmann syndrome. Conflicting results have been reported on the subcellular localiza …
Natural static magnetic field-induced apoptosis in liver cancer cell.
Li J, Ma Y, Li N, Cao Y, Zhu Y. Li J, et al. Electromagn Biol Med. 2014 Jan;33(1):47-50. doi: 10.3109/15368378.2013.783850. Epub 2013 Jun 19. Electromagn Biol Med. 2014. PMID: 23781993
PURPOSE: To observe the apoptotic effects of NSMF on human hepatoma cells and to investigate the mechanisms. MATERIALS AND METHODS: Human hepatoma cell line Bel-7402 and Hep G-2 were treated by 0.2 T rotary NSMF (30 min/d) with 250 Hz, 400 Hz and 500 Hz for 3 d and …
PURPOSE: To observe the apoptotic effects of NSMF on human hepatoma cells and to investigate the mechanisms. MATERIALS AND METHODS: H …
Isolation of a non-sedimenting membrane fraction from the water soluble fraction of bovine lens.
Fleschner CR, Cenedella RJ. Fleschner CR, et al. Exp Eye Res. 1993 Jun;56(6):649-57. doi: 10.1006/exer.1993.1082. Exp Eye Res. 1993. PMID: 8595807
The greater relative amount of total lipid in the NSMF was due to a significantly greater relative amount of phospholipid in the NSMF which was further reflected by the observation that the cholesterol: phospholipid molar ration of the NSMF (0.58) was signifi …
The greater relative amount of total lipid in the NSMF was due to a significantly greater relative amount of phospholipid in the N …
80 results