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90 results

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Page 1
Antigens in membranous nephropathy: discovery and clinical implications.
Sethi S, Fervenza FC. Sethi S, et al. Nat Rev Nephrol. 2025 Oct;21(10):653-670. doi: 10.1038/s41581-025-00980-z. Epub 2025 Jul 21. Nat Rev Nephrol. 2025. PMID: 40691733 Review.
These target antigens include PLA2R, THSD7A, EXT1 and EXT2, NELL1, SEMA3B, NCAM1, CNTN1, HTRA1, FAT1, PCDH7, NTNG1, PCSK6, NDNF and MPO. Several rare putative antigens have also been reported. These findings have transformed our understanding of membranous nephropathy from …
These target antigens include PLA2R, THSD7A, EXT1 and EXT2, NELL1, SEMA3B, NCAM1, CNTN1, HTRA1, FAT1, PCDH7, NTNG1, PCSK6, NDNF and M …
Membranous nephropathy-diagnosis and identification of target antigens.
Sethi S, Fervenza FC. Sethi S, et al. Nephrol Dial Transplant. 2024 Mar 27;39(4):600-606. doi: 10.1093/ndt/gfad227. Nephrol Dial Transplant. 2024. PMID: 37863839 Review.
The newly discovered target antigens include NELL1, EXT1/EXT2, NCAM1, SEMA3B, PCDH7, FAT1, CNTN1, NTNG1, PCSK6 and NDNF. To group all these antigens into a generic 'PLA2R-negative' MN group is imprecise and un-informative. ...
The newly discovered target antigens include NELL1, EXT1/EXT2, NCAM1, SEMA3B, PCDH7, FAT1, CNTN1, NTNG1, PCSK6 and NDNF. To group all …
NTNG1 Modulates Cisplatin Resistance in Epithelial Ovarian Cancer Cells via the GAS6/AXL/Akt Pathway.
Fang S, Luo Y, Zhang Y, Wang H, Liu Q, Li X, Yu T. Fang S, et al. Front Cell Dev Biol. 2021 Jul 1;9:652325. doi: 10.3389/fcell.2021.652325. eCollection 2021. Front Cell Dev Biol. 2021. PMID: 34277602 Free PMC article.
Co-immunoprecipitation demonstrated that NTNG1 bound GAS6/AXL. Silencing NTNG1 enhanced cisplatin effects in vivo, decreasing tumor volume/mass. These data suggested that a high NTNG1 level can result in cisplatin resistance in ovarian cancer cells via the GA …
Co-immunoprecipitation demonstrated that NTNG1 bound GAS6/AXL. Silencing NTNG1 enhanced cisplatin effects in vivo, decreasing …
NTNG1 mutations are a rare cause of Rett syndrome.
Archer HL, Evans JC, Millar DS, Thompson PW, Kerr AM, Leonard H, Christodoulou J, Ravine D, Lazarou L, Grove L, Verity C, Whatley SD, Pilz DT, Sampson JR, Clarke AJ. Archer HL, et al. Am J Med Genet A. 2006 Apr 1;140(7):691-4. doi: 10.1002/ajmg.a.31133. Am J Med Genet A. 2006. PMID: 16502428 Free PMC article.
We sequenced the nine coding exons of NTNG1 and identified four sequence variants, none of which were likely to be pathogenic. Mutations in the NTNG1 gene appear to be a rare cause of RTT but NTNG1 function demands further investigation in relation to the cen …
We sequenced the nine coding exons of NTNG1 and identified four sequence variants, none of which were likely to be pathogenic. Mutati …
Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations.
O'Roak BJ, Vives L, Girirajan S, Karakoc E, Krumm N, Coe BP, Levy R, Ko A, Lee C, Smith JD, Turner EH, Stanaway IB, Vernot B, Malig M, Baker C, Reilly B, Akey JM, Borenstein E, Rieder MJ, Nickerson DA, Bernier R, Shendure J, Eichler EE. O'Roak BJ, et al. Nature. 2012 Apr 4;485(7397):246-50. doi: 10.1038/nature10989. Nature. 2012. PMID: 22495309 Free PMC article.
In proband exomes, recurrent protein-altering mutations were observed in two genes: CHD8 and NTNG1. Mutation screening of six candidate genes in 1,703 ASD probands identified additional de novo, protein-altering mutations in GRIN2B, LAMC3 and SCN1A. ...
In proband exomes, recurrent protein-altering mutations were observed in two genes: CHD8 and NTNG1. Mutation screening of six candida …
Comprehensive analysis of the role of Netrin G1 (NTNG1) in hepatocellular carcinoma cells.
Gao X, Lin Y, Huang X, Lu C, Luo W, Zeng D, Li Y, Su T, Liang R, Ye J. Gao X, et al. Eur J Pharmacol. 2024 Jan 15;963:176262. doi: 10.1016/j.ejphar.2023.176262. Epub 2023 Dec 13. Eur J Pharmacol. 2024. PMID: 38101695
The xenograft model was utilized to verify the tumorigenesis capacity of NTNG1 in vivo. IHC was employed to analyze the expression of NTNG1 and CD163 proteins. ...Bioinformatics analyses indicated that NTNG1 was closely related to EMT and tumor infiltration. …
The xenograft model was utilized to verify the tumorigenesis capacity of NTNG1 in vivo. IHC was employed to analyze the expression of …
Netrin G1 Is a Novel Target Antigen in Primary Membranous Nephropathy.
Reinhard L, Machalitza M, Wiech T, Gröne HJ, Lassé M, Rinschen MM, Ferru N, Bräsen JH, Drömann F, Rob PM, Sethi S, Hoxha E, Stahl RAK. Reinhard L, et al. J Am Soc Nephrol. 2022 Oct;33(10):1823-1831. doi: 10.1681/ASN.2022050608. Epub 2022 Aug 19. J Am Soc Nephrol. 2022. PMID: 35985817 Free PMC article.
Immunohistochemistry confirmed granular NTNG1 positivity in subepithelial glomerular immune deposits. In prospective and retrospective MN cohorts, we identified three patients with NTNG1-associated MN who showed IgG4-dominant circulating NTNG1 autoantibodies, …
Immunohistochemistry confirmed granular NTNG1 positivity in subepithelial glomerular immune deposits. In prospective and retrospectiv …
Replication of NTNG1 association in schizophrenia.
Wilcox JA, Quadri S. Wilcox JA, et al. Psychiatr Genet. 2014 Dec;24(6):266-8. doi: 10.1097/YPG.0000000000000061. Psychiatr Genet. 2014. PMID: 25325217
This is a case-control study of the association of NTNG1 subtypes with schizophrenia among a group of individuals from a Caucasian population. Netrins including NTNG1 are known to be axon guidance factors in the developing brain. They could be very important contrib …
This is a case-control study of the association of NTNG1 subtypes with schizophrenia among a group of individuals from a Caucasian po …
SARS-CoV-2 orf1b Gene Sequence in the NTNG1 Gene on Human Chromosome 1.
Lehrer S, Rheinstein PH. Lehrer S, et al. In Vivo. 2020 Jun;34(3 Suppl):1629-1632. doi: 10.21873/invivo.11953. In Vivo. 2020. PMID: 32503821 Free PMC article.
The sequence was in chromosome 1p within an intronic region of the netrin G1 (NTNG1) gene. The sequence matched a sequence in the SARS-CoV-2 orf1b (open reading frames) gene. ...It is probably no accident that a sequence from the SARS-CoV-2 orf1b gene is found in the human …
The sequence was in chromosome 1p within an intronic region of the netrin G1 (NTNG1) gene. The sequence matched a sequence in the SAR …
A Genetic Study of Cerebral Atherosclerosis Reveals Novel Associations with NTNG1 and CNOT3.
Vattathil SM, Liu Y, Harerimana NV, Lori A, Gerasimov ES, Beach TG, Reiman EM, De Jager PL, Schneider JA, Bennett DA, Seyfried NT, Levey AI, Wingo AP, Wingo TS. Vattathil SM, et al. Genes (Basel). 2021 May 26;12(6):815. doi: 10.3390/genes12060815. Genes (Basel). 2021. PMID: 34073619 Free PMC article.
From our analysis of 1325 participants of European ancestry who had genotype and neuropathologically assessed cerebral atherosclerosis measures available, we found a novel locus for cerebral atherosclerosis in NTNG1. The locus comprises eight SNPs, including two independen …
From our analysis of 1325 participants of European ancestry who had genotype and neuropathologically assessed cerebral atherosclerosis measu …
90 results