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89 results

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Page 1
NUP160 knockdown inhibits the progression of diabetic nephropathy in vitro and in vivo.
Xie J, Chen Z, Yao G, Yuan Y, Yu W, Zhu Q. Xie J, et al. Regen Ther. 2022 Jun 17;21:87-95. doi: 10.1016/j.reth.2022.05.011. eCollection 2022 Dec. Regen Ther. 2022. PMID: 35785044 Free PMC article.
Mechanistically, miR-495-3p directly targeted NUP160, and lncRNA HCG18 upregulated NUP160 by sponging miR-495-3p by acting as a ceRNA. ...The in vivo assays indicated that NUP160 knockdown alleviated the symptoms of DN rats. NUP160 knockdown plays a ke …
Mechanistically, miR-495-3p directly targeted NUP160, and lncRNA HCG18 upregulated NUP160 by sponging miR-495-3p by acting as …
Podocyte-specific Nup160 knockout mice develop nephrotic syndrome and glomerulosclerosis.
Li Y, Xu C, Zhao F, Liu Q, Qiu X, Li M, Yang Y, Yu S, Tong H, Zhang L, Chen B, Qu L, Yu Z. Li Y, et al. Hum Mol Genet. 2024 Apr 8;33(8):667-676. doi: 10.1093/hmg/ddad211. Hum Mol Genet. 2024. PMID: 38224683
Our previous study found that mutations in nucleoporin 160 kD (NUP160) are implicated in SRNS. The NUP160 gene encodes a component of the nuclear pore complex. Recently, two siblings with homozygous NUP160 mutations presented with SRNS and a nervous system di …
Our previous study found that mutations in nucleoporin 160 kD (NUP160) are implicated in SRNS. The NUP160 gene encodes a compo …
Nucleoporin 160 (NUP160) inhibition alleviates diabetic nephropathy by activating autophagy.
Xie J, Yuan Y, Yao G, Chen Z, Yu W, Zhu Q. Xie J, et al. Bioengineered. 2021 Dec;12(1):6390-6402. doi: 10.1080/21655979.2021.1968777. Bioengineered. 2021. PMID: 34533106 Free PMC article.
Moreover, NUP160 knockdown could ameliorate pathological damage and glucose tolerance in DN mice. Overall, this study is the first to demonstrate the key role of NUP160 silencing in promoting autophagy against diabetic injury in DN....
Moreover, NUP160 knockdown could ameliorate pathological damage and glucose tolerance in DN mice. Overall, this study is the first to …
Mutations in NUP160 Are Implicated in Steroid-Resistant Nephrotic Syndrome.
Zhao F, Zhu JY, Richman A, Fu Y, Huang W, Chen N, Pan X, Yi C, Ding X, Wang S, Wang P, Nie X, Huang J, Yang Y, Yu Z, Han Z. Zhao F, et al. J Am Soc Nephrol. 2019 May;30(5):840-853. doi: 10.1681/ASN.2018080786. Epub 2019 Mar 25. J Am Soc Nephrol. 2019. PMID: 30910934 Free PMC article.
We performed in vivo functional validation studies on the NUP160 mutations using a Drosophila model. RESULTS: We identified two compound-heterozygous NUP160 mutations, NUP160(R1173) and NUP160(E803K) . ...CONCLUSIONS: Mutations in NUP160 are imp …
We performed in vivo functional validation studies on the NUP160 mutations using a Drosophila model. RESULTS: We identified two compo …
Role and Mechanism of NUP160-regulated Autophagy in Pathogenesis of Diabetic Nephropathy.
Xie J, Yuan Y, Yao G, Yu W, Zhu Q. Xie J, et al. Iran J Kidney Dis. 2023 Nov;17(6):327-334. doi: 10.52547/ijkd.7884. Iran J Kidney Dis. 2023. PMID: 38043110
This research project aims to investigate the role and mechanism of Nucleoporin 160kDa (NUP160)-regulated autophagy in the pathogenesis of DN. METHODS: NUP160 levels in diabetic and non-diabetic kidney tissues were measured by Western blot, and the connection betwee …
This research project aims to investigate the role and mechanism of Nucleoporin 160kDa (NUP160)-regulated autophagy in the pathogenes …
M6A-Methylated circRAPGEF5 drives lung adenocarcinoma progression and metastasis via IGF2BP2/NUP160-mediated autophagy suppression.
Ling L, Hu T, Zhou C, Dai Y, Hu L, Chen Y, Hu Z, Huang K, Chen J, Wang Y. Ling L, et al. Mol Cancer. 2025 Jul 8;24(1):192. doi: 10.1186/s12943-025-02399-3. Mol Cancer. 2025. PMID: 40629330 Free PMC article.
This interaction facilitated IGF2BP2-mediated stabilization of NUP160 mRNA, a nuclear pore complex component. Genetic ablation of NUP160 through RNA interference effectively restored autophagic activity, thereby attenuating the aggressive biological behaviors of LUA …
This interaction facilitated IGF2BP2-mediated stabilization of NUP160 mRNA, a nuclear pore complex component. Genetic ablation of …
The nucleoporin NUP160 and NUP96 regulate nucleocytoplasmic export of mRNAs and participate in ethylene signaling and response in Arabidopsis.
Nie Y, Li Y, Liu M, Ma B, Sui X, Chen J, Yu Y, Dong CH. Nie Y, et al. Plant Cell Rep. 2023 Mar;42(3):549-559. doi: 10.1007/s00299-022-02976-6. Epub 2023 Jan 4. Plant Cell Rep. 2023. PMID: 36598573
However, little is known about the regulatory functions of the nucleoporin NUP160 and NUP96 in ethylene signaling pathway. In the present study, we provided data showing that the Arabidopsis nucleoporin NUP160 and NUP96 participate in ethylene signaling-related mRNA …
However, little is known about the regulatory functions of the nucleoporin NUP160 and NUP96 in ethylene signaling pathway. In the pre …
An improved smaller biotin ligase for BioID proximity labeling.
Kim DI, Jensen SC, Noble KA, Kc B, Roux KH, Motamedchaboki K, Roux KJ. Kim DI, et al. Mol Biol Cell. 2016 Apr 15;27(8):1188-96. doi: 10.1091/mbc.E15-12-0844. Epub 2016 Feb 24. Mol Biol Cell. 2016. PMID: 26912792 Free PMC article.
NUP160-SLC43A3 is a novel recurrent fusion oncogene in angiosarcoma.
Shimozono N, Jinnin M, Masuzawa M, Masuzawa M, Wang Z, Hirano A, Tomizawa Y, Etoh-Kira T, Kajihara I, Harada M, Fukushima S, Ihn H. Shimozono N, et al. Cancer Res. 2015 Nov 1;75(21):4458-65. doi: 10.1158/0008-5472.CAN-15-0418. Cancer Res. 2015. PMID: 26527604
In this study, we investigated this issue by transcriptome sequencing of patient-derived angiosarcoma cells (ISO-HAS), identifying a novel fusion gene NUP160-SLC43A3 found to be expressed in 9 of 25 human angiosarcoma specimens that were examined. ...Stable expression of t …
In this study, we investigated this issue by transcriptome sequencing of patient-derived angiosarcoma cells (ISO-HAS), identifying a novel f …
89 results