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Low-Dose versus Standard-Dose Intravenous Alteplase in Acute Ischemic Stroke.
Anderson CS, Robinson T, Lindley RI, Arima H, Lavados PM, Lee TH, Broderick JP, Chen X, Chen G, Sharma VK, Kim JS, Thang NH, Cao Y, Parsons MW, Levi C, Huang Y, Olavarría VV, Demchuk AM, Bath PM, Donnan GA, Martins S, Pontes-Neto OM, Silva F, Ricci S, Roffe C, Pandian J, Billot L, Woodward M, Li Q, Wang X, Wang J, Chalmers J; ENCHANTED Investigators and Coordinators. Anderson CS, et al. N Engl J Med. 2016 Jun 16;374(24):2313-23. doi: 10.1056/NEJMoa1515510. Epub 2016 May 10. N Engl J Med. 2016. PMID: 27161018 Free article. Clinical Trial.
Cluster-Randomized, Crossover Trial of Head Positioning in Acute Stroke.
Anderson CS, Arima H, Lavados P, Billot L, Hackett ML, Olavarría VV, Muñoz Venturelli P, Brunser A, Peng B, Cui L, Song L, Rogers K, Middleton S, Lim JY, Forshaw D, Lightbody CE, Woodward M, Pontes-Neto O, De Silva HA, Lin RT, Lee TH, Pandian JD, Mead GE, Robinson T, Watkins C; HeadPoST Investigators and Coordinators. Anderson CS, et al. N Engl J Med. 2017 Jun 22;376(25):2437-2447. doi: 10.1056/NEJMoa1615715. N Engl J Med. 2017. PMID: 28636854 Free article. Clinical Trial.
Effects of Intensive Blood Pressure Lowering on Brain Swelling in Thrombolyzed Acute Ischemic Stroke: The ENCHANTED Results.
Zhang G, Chen C, Ren X, Zhao Y, Ouyang M, Billot L, Li Q, Wang X, Zhang L, Ong S, Liu L, You S, Lindley RI, Robinson TG, Li G, Chen X, Sui Y, Anderson CS, Song L; ENCHANTED Investigators. Zhang G, et al. Stroke. 2025 Jun;56(6):1388-1395. doi: 10.1161/STROKEAHA.124.049938. Epub 2025 Apr 3. Stroke. 2025. PMID: 40177745 Clinical Trial.
Low blood pressure and adverse outcomes in acute stroke: HeadPoST study explanations.
Ouyang M, Muñoz-Venturelli P, Billot L, Wang X, Song L, Arima H, Lavados PM, Hackett ML, Olavarría VV, Brunser A, Middleton S, Pontes-Neto OM, Lee TH, Watkins CL, Robinson T, Anderson CS. Ouyang M, et al. J Hypertens. 2021 Feb 1;39(2):273-279. doi: 10.1097/HJH.0000000000002649. J Hypertens. 2021. PMID: 32897905 Free PMC article. Clinical Trial.
Cervical Artery Dissections with and without stroke, risk factors and prognosis: a Chilean prospective cohort.
Mazzon E, Rocha D, Brunser AM, De la Barra C, Stecher X, Bernstein T, Zúñiga P, Díaz V, Martínez G, Muñoz Venturelli P. Mazzon E, et al. J Stroke Cerebrovasc Dis. 2020 Aug;29(8):104992. doi: 10.1016/j.jstrokecerebrovasdis.2020.104992. Epub 2020 Jun 14. J Stroke Cerebrovasc Dis. 2020. PMID: 32689597

Conversely, vertebral artery dissection (OR 0.35, 95% CI 0.16-0.74, P = 0.006) and longer symptom onset to admission (O-A) time (OR 0.79, 95% CI 0.70-0.90, P < 0.001) were associated to decreased stroke risk. After multivariate analysis, men (OR 2.88, 95% CI 1.32-6.27,

…
Conversely, vertebral artery dissection (OR 0.35, 95% CI 0.16-0.74, P = 0.006) and longer symptom onset to admission (O-A) time (OR 0 …