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Synthesis, characterization, antidiabetic and antioxidative evaluation of a novel Zn(II)-gallic acid complex with multi-facet activity.
Motloung DM, Mashele SS, Matowane GR, Swain SS, Bonnet SL, Noreljaleel AEM, Oyedemi SO, Chukwuma CI. Motloung DM, et al. J Pharm Pharmacol. 2020 Oct;72(10):1412-1426. doi: 10.1111/jphp.13322. Epub 2020 Jul 8. J Pharm Pharmacol. 2020. PMID: 32639035
KEY FINDINGS: Analysis showed that complexation occurred through a Zn(O(4) ) coordination; thus, the complex acquired two moieties of gallic acid, which suggests why complexation increased the DPPH (IC(50) = 48.2 m) and ABTS (IC(50) = 12.7 m) scavenging a …
KEY FINDINGS: Analysis showed that complexation occurred through a Zn(O(4) ) coordination; thus, the complex acquired two moieties of …
Zinc(II) - Syringic acid complexation synergistically exerts antioxidant action and modulates glucose uptake and utilization in L-6 myotubes and rat muscle tissue.
Ramorobi LM, Matowane GR, Mashele SS, Swain SS, Makhafola TJ, Mfengwana PH, Chukwuma CI. Ramorobi LM, et al. Biomed Pharmacother. 2022 Oct;154:113600. doi: 10.1016/j.biopha.2022.113600. Epub 2022 Aug 26. Biomed Pharmacother. 2022. PMID: 36037784 Free article.
Different experimental models were used to compare the anti-hyperglycaemic and antioxidant properties between the complex and precursors. A Zn(II)-bisyringate.2H(2)O complex was formed. The in vitro radical scavenging and Fe(3+) reducing antioxidant, antiglycation, and alp …
Different experimental models were used to compare the anti-hyperglycaemic and antioxidant properties between the complex and precursors. A …