hnRNP R promotes O-GlcNAcylation of eIF4G and facilitates axonal protein synthesis.
Zare A, Salehi S, Bader J, Schneider C, Fischer U, Veh A, Arampatzi P, Mann M, Briese M, Sendtner M.
Zare A, et al.
Nat Commun. 2024 Aug 28;15(1):7430. doi: 10.1038/s41467-024-51678-y.
Nat Commun. 2024.
PMID: 39198412
Free PMC article.
In axons, hnRNP R is a component of translation initiation complexes and, through interaction with O-linked beta-N-acetylglucosamine (O-GlcNAc) transferase (Ogt), modulates O-GlcNAcylation of eIF4G. Restoring axonal O-GlcNAc levels rescued local protei …
In axons, hnRNP R is a component of translation initiation complexes and, through interaction with O-linked beta-N-acetylglucosamine …