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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1953 3
1955 2
1956 1
1957 2
1959 2
1960 2
1961 9
1962 8
1963 8
1964 6
1965 10
1966 15
1967 12
1968 7
1969 12
1970 15
1971 3
1972 13
1973 13
1974 13
1975 18
1976 19
1977 19
1978 30
1979 28
1980 20
1981 30
1982 36
1983 41
1984 41
1985 47
1986 47
1987 42
1988 38
1989 43
1990 31
1991 55
1992 41
1993 62
1994 80
1995 55
1996 83
1997 81
1998 98
1999 87
2000 105
2001 105
2002 113
2003 106
2004 129
2005 139
2006 137
2007 130
2008 126
2009 119
2010 166
2011 180
2012 210
2013 232
2014 197
2015 208
2016 206
2017 218
2018 220
2019 223
2020 251
2021 304
2022 267
2023 231
2024 251
2025 258
2026 138

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5,744 results

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Page 1
Targeting PDGF signaling of cancer-associated fibroblasts blocks feedback activation of HIF-1α and tumor progression of clear cell ovarian cancer.
Mori Y, Okimoto Y, Sakai H, Kanda Y, Ohata H, Shiokawa D, Suzuki M, Yoshida H, Ueda H, Sekizuka T, Tamura R, Yamawaki K, Ishiguro T, Mateos RN, Shiraishi Y, Yatabe Y, Hamada A, Yoshihara K, Enomoto T, Okamoto K. Mori Y, et al. Among authors: okamoto k. Cell Rep Med. 2024 May 21;5(5):101532. doi: 10.1016/j.xcrm.2024.101532. Epub 2024 Apr 25. Cell Rep Med. 2024. PMID: 38670097 Free PMC article.
Integrated spatial and single-cell transcriptomics reveal PAK kinase as a therapeutic target in fibroblastic foci and dense fibrosis of idiopathic pulmonary fibrosis.
Watanabe N, Yoshida M, Hirano Y, Fujimoto S, Matsubayashi S, Ishiguro T, Takahashi N, Shimizu Y, Takayanagi N, Kawabata Y, Mori Y, Okamoto K, Minagawa S, Kuwano K, Araya J, Yamamoto Y, Fujita Y. Watanabe N, et al. Among authors: okamoto k. Eur Respir J. 2025 Oct 7;66(4):2500022. doi: 10.1183/13993003.00022-2025. Print 2025 Oct. Eur Respir J. 2025. PMID: 40675771 Free PMC article.
Acquired Osteomalacia Associated with Autoantibodies against PHEX.
Hoshino Y, Okamoto K, Ogawa T, Kato H, Irie K, Watanabe S, Kimura S, Hidaka N, Kinoshita Y, Kobayashi H, Hagiwara D, Kogawa M, Takayanagi H, Tanaka S, Nangaku M, Makita N, Burbelo PD, Saito T, Ito N. Hoshino Y, et al. Among authors: okamoto k. N Engl J Med. 2025 Jan 30;392(5):513-515. doi: 10.1056/NEJMc2405746. N Engl J Med. 2025. PMID: 39879599 Free PMC article. No abstract available.
The periosteum provides a stromal defence against cancer invasion into the bone.
Nakamura K, Tsukasaki M, Tsunematsu T, Yan M, Ando Y, Huynh NC, Hashimoto K, Gou Q, Muro R, Itabashi A, Iguchi T, Okamoto K, Nakamura T, Nakano K, Okamura T, Ueno T, Ito K, Ishimaru N, Hoshi K, Takayanagi H. Nakamura K, et al. Among authors: okamoto k. Nature. 2024 Oct;634(8033):474-481. doi: 10.1038/s41586-024-07822-1. Epub 2024 Aug 21. Nature. 2024. PMID: 39169177
Clinical practice guidelines for management of disseminated intravascular coagulation in Japan 2024. Part 1: sepsis.
Yamakawa K, Okamoto K, Seki Y, Ikezoe T, Ito T, Iba T, Gando S, Ushio N, Totoki T, Wada T, Asakura H, Ishikura H, Uchiba M, Uchiyama T, Kawasaki K, Kawano N, Kushimoto S, Koga S, Sakamoto Y, Tamura T, Nishio K, Hayakawa M, Matsumoto T, Madoiwa S, Mayumi T, Yamada S, Wada H; Committee of the Clinical Practice Guidelines for Management of Disseminated Intravascular Coagulation 2024, the Japanese Society on Thrombosis and Hemostasis. Yamakawa K, et al. Among authors: okamoto k. Int J Hematol. 2025 May;121(5):592-604. doi: 10.1007/s12185-024-03896-9. Epub 2024 Dec 16. Int J Hematol. 2025. PMID: 39676120 Review.
Proposal and Validation of a Clinically Relevant Modification of the Japanese Association for Acute Medicine Disseminated Intravascular Coagulation Diagnostic Criteria for Sepsis.
Yamakawa K, Umemura Y, Mochizuki K, Matsuoka T, Wada T, Hayakawa M, Iba T, Ohtomo Y, Okamoto K, Mayumi T, Ikeda T, Ishikura H, Ogura H, Kushimoto S, Saitoh D, Gando S. Yamakawa K, et al. Among authors: okamoto k. Thromb Haemost. 2024 Nov;124(11):1003-1012. doi: 10.1055/s-0044-1786808. Epub 2024 May 10. Thromb Haemost. 2024. PMID: 38729189 Free PMC article.
Clinical practice guidelines for management of disseminated intravascular coagulation in Japan 2024. Part 2: hematologic malignancy.
Kawano N, Ikezoe T, Seki Y, Yamakawa K, Okamoto K, Fukatsu M, Madoiwa S, Uchiyama T, Asakura H, Yamada S, Koga S, Ishikura H, Ito T, Iba T, Uchiba M, Kawasaki K, Gando S, Kushimoto S, Sakamoto Y, Tamura T, Nishio K, Hayakawa M, Matsumoto T, Mayumi T, Wada H; Committee of the Clinical Practice Guidelines for Disseminated Intravascular Coagulation 2024, the Japanese Society on Thrombosis and Hemostasis. Kawano N, et al. Among authors: okamoto k. Int J Hematol. 2025 May;121(5):605-621. doi: 10.1007/s12185-024-03887-w. Epub 2024 Dec 15. Int J Hematol. 2025. PMID: 39674834
5,744 results