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104 results

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Page 1
Orc4 spatiotemporally stabilizes centromeric chromatin.
Sreekumar L, Kumari K, Guin K, Bakshi A, Varshney N, Thimmappa BC, Narlikar L, Padinhateeri R, Siddharthan R, Sanyal K. Sreekumar L, et al. Genome Res. 2021 Apr;31(4):607-621. doi: 10.1101/gr.265900.120. Epub 2021 Jan 29. Genome Res. 2021. PMID: 33514624 Free PMC article.
In this study, the genome-wide occupancy of the replication initiation protein Orc4 reveals its abundance at all centromeres in C. albicans Orc4 is associated with four different DNA sequence motifs, one of which coincides with tRNA genes (tDNA) that replicate early …
In this study, the genome-wide occupancy of the replication initiation protein Orc4 reveals its abundance at all centromeres in C. al …
Deletion of Orc4 during oogenesis severely reduces polar body extrusion and blocks zygotic DNA replication.
Nguyen H, Wu H, Ung A, Yamazaki Y, Fogelgren B, Ward WS. Nguyen H, et al. Biol Reprod. 2022 Apr 26;106(4):730-740. doi: 10.1093/biolre/ioab237. Biol Reprod. 2022. PMID: 34977916 Free PMC article.
Orc4 deletion severely reduced PBE. Almost half of Orc4-depleted germinal vesicle (GV) oocytes cultured in vitro were arrested before anaphase I (48%), and only 25% produced normal first polar bodies. This supports the role of ORC4 in PBE and suggests that tr …
Orc4 deletion severely reduced PBE. Almost half of Orc4-depleted germinal vesicle (GV) oocytes cultured in vitro were arrested …
ORC4 surrounds extruded chromatin in female meiosis.
Nguyen H, Ortega MA, Ko M, Marh J, Ward WS. Nguyen H, et al. J Cell Biochem. 2015 May;116(5):778-86. doi: 10.1002/jcb.25033. J Cell Biochem. 2015. PMID: 25502171 Free PMC article.
When the zygote entered mitosis ORC4 was only detected in the polar body. However, ORC4 appeared on both sets of separating chromosomes at telophase. At this point, the ORC4 that was in the polar body also migrated into the nuclei, suggesting that ORC4 …
When the zygote entered mitosis ORC4 was only detected in the polar body. However, ORC4 appeared on both sets of separating ch …
The role of ORC4 in enucleation of Murine Erythroleukemia (MEL) cells is similar to that in oocyte polar body extrusion.
Nguyen H, Ung A, Ward WS. Nguyen H, et al. Syst Biol Reprod Med. 2020 Dec;66(6):378-386. doi: 10.1080/19396368.2020.1822458. Epub 2020 Sep 24. Syst Biol Reprod Med. 2020. PMID: 32972244 Free PMC article.
We then tested whether ORC4 was required for MEL enucleation by down regulating ORC4 with siRNA-ORC4 during Vacuolin-1 treatment and found that this prevented MEL enucleation. These data are consistent with the model that ORC4 is required for erythrobl …
We then tested whether ORC4 was required for MEL enucleation by down regulating ORC4 with siRNA-ORC4 during Vacuolin-1 …
Meier-Gorlin syndrome.
de Munnik SA, Hoefsloot EH, Roukema J, Schoots J, Knoers NV, Brunner HG, Jackson AP, Bongers EM. de Munnik SA, et al. Orphanet J Rare Dis. 2015 Sep 17;10:114. doi: 10.1186/s13023-015-0322-x. Orphanet J Rare Dis. 2015. PMID: 26381604 Free PMC article. Review.
In patients with short stature and/or microtia, the patellae should be assessed with care by ultrasonography before age 6 or radiography thereafter. Mutations in one of five genes (ORC1, ORC4, ORC6, CDT1, and CDC6) of the pre-replication complex, involved in DNA-replicatio …
In patients with short stature and/or microtia, the patellae should be assessed with care by ultrasonography before age 6 or radiography the …
Higher Order Oligomerization of the Licensing ORC4 Protein Is Required for Polar Body Extrusion in Murine Meiosis.
Nguyen H, James NG, Nguyen L, Nguyen TP, Vuong C, Ortega MA, Jameson DM, Ward WS. Nguyen H, et al. J Cell Biochem. 2017 Sep;118(9):2941-2949. doi: 10.1002/jcb.25949. Epub 2017 May 3. J Cell Biochem. 2017. PMID: 28230328 Free PMC article.
We termed this structure the ORC4 cage. Here, we tested whether the formation of the ORC4 cage is necessary for polar body extrusion (PBE). ...Together, these data demonstrate that ORC4 oligomerization is required to form the ORC4 cage and that it is r …
We termed this structure the ORC4 cage. Here, we tested whether the formation of the ORC4 cage is necessary for polar body ext …
Tissue-Specific DNA Replication Defects in Drosophila melanogaster Caused by a Meier-Gorlin Syndrome Mutation in Orc4.
McDaniel SL, Hollatz AJ, Branstad AM, Gaskill MM, Fox CA, Harrison MM. McDaniel SL, et al. Genetics. 2020 Feb;214(2):355-367. doi: 10.1534/genetics.119.302938. Epub 2019 Dec 9. Genetics. 2020. PMID: 31818869 Free PMC article.
Flies homozygous for the engineered MGS allele reach adulthood, but with several tissue-specific defects. Genetic analysis revealed that this Orc4 allele was a hypomorph. Mutant females were sterile, and phenotypic analyses suggested that defects in DNA replication was an …
Flies homozygous for the engineered MGS allele reach adulthood, but with several tissue-specific defects. Genetic analysis revealed that thi …
Mutations in origin recognition complex gene ORC4 cause Meier-Gorlin syndrome.
Guernsey DL, Matsuoka M, Jiang H, Evans S, Macgillivray C, Nightingale M, Perry S, Ferguson M, LeBlanc M, Paquette J, Patry L, Rideout AL, Thomas A, Orr A, McMaster CR, Michaud JL, Deal C, Langlois S, Superneau DW, Parkash S, Ludman M, Skidmore DL, Samuels ME. Guernsey DL, et al. Nat Genet. 2011 Feb 27;43(4):360-4. doi: 10.1038/ng.777. Nat Genet. 2011. PMID: 21358631
In two such individuals that were negative for mutations in ORC4, we found potential mutations in ORC1 and CDT1, two other genes involved in origin recognition. ORC4 is well conserved in eukaryotes, and the yeast equivalent of the human ORC4 missense mutation …
In two such individuals that were negative for mutations in ORC4, we found potential mutations in ORC1 and CDT1, two other genes invo …
ORC proteins in the mammalian zygote.
Ortega MA, Nguyen H, Ward WS. Ortega MA, et al. Cell Tissue Res. 2016 Jan;363(1):195-200. doi: 10.1007/s00441-015-2296-3. Epub 2015 Oct 9. Cell Tissue Res. 2016. PMID: 26453397 Free PMC article. Review.
ORC1, 2, 3, and 5 all localize to the area between the separating maternal chromosomes shortly after fertilization. ORC4 forms a cage around the set of chromosomes that will be extruded during polar body formation before it binds to the chromatin shortly before zygotic DNA …
ORC1, 2, 3, and 5 all localize to the area between the separating maternal chromosomes shortly after fertilization. ORC4 forms a cage …
Humanizing the yeast origin recognition complex.
Lee CSK, Cheung MF, Li J, Zhao Y, Lam WH, Ho V, Rohs R, Zhai Y, Leung D, Tye BK. Lee CSK, et al. Nat Commun. 2021 Jan 4;12(1):33. doi: 10.1038/s41467-020-20277-y. Nat Commun. 2021. PMID: 33397927 Free PMC article.
In this work, we demonstrate that the selectivity determinant of ORC for DNA binding lies in a 19-amino acid insertion helix in the Orc4 subunit, which is present in yeast but absent in human. Removal of this motif from Orc4 transforms the yeast ORC, which selects o …
In this work, we demonstrate that the selectivity determinant of ORC for DNA binding lies in a 19-amino acid insertion helix in the Orc4 …
104 results