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A single-nucleotide polymorphism in a Plasmodium berghei ApiAP2 transcription factor alters the development of host immunity.
Akkaya M, Bansal A, Sheehan PW, Pena M, Molina-Cruz A, Orchard LM, Cimperman CK, Qi CF, Ross P, Yazew T, Sturdevant D, Anzick SL, Thiruvengadam G, Otto TD, Billker O, Llinás M, Miller LH, Pierce SK. Akkaya M, et al. Among authors: orchard lm. Sci Adv. 2020 Feb 5;6(6):eaaw6957. doi: 10.1126/sciadv.aaw6957. eCollection 2020 Feb. Sci Adv. 2020. PMID: 32076635 Free PMC article.
A seven-helix protein constitutes stress granules crucial for regulating translation during human-to-mosquito transmission of Plasmodium falciparum.
Bennink S, von Bohl A, Ngwa CJ, Henschel L, Kuehn A, Pilch N, Weißbach T, Rosinski AN, Scheuermayer M, Repnik U, Przyborski JM, Minns AM, Orchard LM, Griffiths G, Lindner SE, Llinás M, Pradel G. Bennink S, et al. Among authors: orchard lm. PLoS Pathog. 2018 Aug 22;14(8):e1007249. doi: 10.1371/journal.ppat.1007249. eCollection 2018 Aug. PLoS Pathog. 2018. PMID: 30133543 Free PMC article.
Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response Box.
Reader J, van der Watt ME, Taylor D, Le Manach C, Mittal N, Ottilie S, Theron A, Moyo P, Erlank E, Nardini L, Venter N, Lauterbach S, Bezuidenhout B, Horatscheck A, van Heerden A, Spillman NJ, Cowell AN, Connacher J, Opperman D, Orchard LM, Llinás M, Istvan ES, Goldberg DE, Boyle GA, Calvo D, Mancama D, Coetzer TL, Winzeler EA, Duffy J, Koekemoer LL, Basarab G, Chibale K, Birkholtz LM. Reader J, et al. Among authors: orchard lm. Nat Commun. 2021 Jan 11;12(1):269. doi: 10.1038/s41467-020-20629-8. Nat Commun. 2021. PMID: 33431834 Free PMC article.
Transcriptional Profiling Defines Histone Acetylation as a Regulator of Gene Expression during Human-to-Mosquito Transmission of the Malaria Parasite Plasmodium falciparum.
Ngwa CJ, Kiesow MJ, Papst O, Orchard LM, Filarsky M, Rosinski AN, Voss TS, Llinás M, Pradel G. Ngwa CJ, et al. Among authors: orchard lm. Front Cell Infect Microbiol. 2017 Jul 24;7:320. doi: 10.3389/fcimb.2017.00320. eCollection 2017. Front Cell Infect Microbiol. 2017. PMID: 28791254 Free PMC article.
Characterization of the Plasmodium falciparum and P. berghei glycerol 3-phosphate acyltransferase involved in FASII fatty acid utilization in the malaria parasite apicoplast.
Shears MJ, MacRae JI, Mollard V, Goodman CD, Sturm A, Orchard LM, Llinás M, McConville MJ, Botté CY, McFadden GI. Shears MJ, et al. Among authors: orchard lm. Cell Microbiol. 2017 Jan;19(1):e12633. doi: 10.1111/cmi.12633. Epub 2016 Aug 1. Cell Microbiol. 2017. PMID: 27324409 Free PMC article.
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