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A noncanonical AR addiction drives enzalutamide resistance in prostate cancer.

He Y, Wei T, Ye Z, Orme JJ, Lin D, Sheng H, Fazli L, Jeffrey Karnes R, Jimenez R, Wang L, Wang L, Gleave ME, Wang Y, Shi L, Huang H. He Y, et al. Among authors: orme jj. Nat Commun. 2021 Mar 9;12(1):1521. doi: 10.1038/s41467-021-21860-7. Nat Commun. 2021. PMID: 33750801 Free PMC article.

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Mutated SPOP E3 Ligase Promotes 17βHSD4 Protein Degradation to Drive Androgenesis and Prostate Cancer Progression.

Shi L, Yan Y, He Y, Yan B, Pan Y, Orme JJ, Zhang J, Xu W, Pang J, Huang H. Shi L, et al. Among authors: orme jj. Cancer Res. 2021 Jul 1;81(13):3593-3606. doi: 10.1158/0008-5472.CAN-20-3258. Epub 2021 Mar 24. Cancer Res. 2021. PMID: 33762355

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Microenvironment-Mediated Resistance to Anti-Androgen Therapy.

Orme JJ, Huang H. Orme JJ, et al. Cancer Cell. 2020 Aug 10;38(2):155-157. doi: 10.1016/j.ccell.2020.07.007. Cancer Cell. 2020. PMID: 32781041 Free article.

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An acetyl-histone vulnerability in PI3K/AKT inhibition-resistant cancers is targetable by both BET and HDAC inhibitors.

Wu D, Yan Y, Wei T, Ye Z, Xiao Y, Pan Y, Orme JJ, Wang D, Wang L, Ren S, Huang H. Wu D, et al. Among authors: orme jj. Cell Rep. 2021 Feb 16;34(7):108744. doi: 10.1016/j.celrep.2021.108744. Cell Rep. 2021. PMID: 33596421 Free article.

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CMTM6 expression as a potential biomarker for immunotherapy in metastatic renal cell carcinoma.

Tulchiner G, Brunner A, Schmidinger M, Staudacher N, Orme JJ, Thurnher M, Horninger W, Culig Z, Pichler R. Tulchiner G, et al. Among authors: orme jj. BJU Int. 2021 Jul;128(1):29-32. doi: 10.1111/bju.15341. Epub 2021 Feb 7. BJU Int. 2021. PMID: 33455021 Free PMC article. No abstract available.

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ADAM10 and ADAM17 cleave PD-L1 to mediate PD-(L)1 inhibitor resistance.

Orme JJ, Jazieh KA, Xie T, Harrington S, Liu X, Ball M, Madden B, Charlesworth MC, Azam TU, Lucien F, Wootla B, Li Y, Villasboas JC, Mansfield AS, Dronca RS, Dong H. Orme JJ, et al. Oncoimmunology. 2020 Apr 14;9(1):1744980. doi: 10.1080/2162402X.2020.1744980. eCollection 2020. Oncoimmunology. 2020. PMID: 32363112 Free PMC article.

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Expression of ADAM Proteases in Bladder Cancer Patients with BCG Failure: A Pilot Study.

Pichler R, Lindner AK, Schäfer G, Tulchiner G, Staudacher N, Mayr M, Comperat E, Orme JJ, Schachtner G, Thurnher M. Pichler R, et al. Among authors: orme jj. J Clin Med. 2021 Feb 14;10(4):764. doi: 10.3390/jcm10040764. J Clin Med. 2021. PMID: 33672843 Free PMC article.

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Chemotherapy with atezolizumab for small cell or neuroendocrine carcinoma of the prostate: A single institution experience.

Wee CE, Costello BA, Orme JJ, Quevedo JF, Pagliaro LC. Wee CE, et al. Among authors: orme jj. Prostate. 2021 Sep;81(13):938-943. doi: 10.1002/pros.24189. Epub 2021 Jul 12. Prostate. 2021. PMID: 34254332

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Phase II Evaluation of Stereotactic Ablative Radiotherapy (SABR) and Immunity in ¹¹C-Choline-PET/CT-Identified Oligometastatic Castration-Resistant Prostate Cancer.

Zhang H, Orme JJ, Abraha F, Stish BJ, Lowe VJ, Lucien F, Tryggestad EJ, Bold MS, Pagliaro LC, Choo CR, Brinkmann DH, Iott MJ, Davis BJ, Quevedo JF, Harmsen WS, Costello BA, Johnson GB, Nathan MA, Olivier KR, Pisansky TM, Kwon ED, Dong H, Park SS. Zhang H, et al. Among authors: orme jj. Clin Cancer Res. 2021 Dec 1;27(23):6376-6383. doi: 10.1158/1078-0432.CCR-21-2510. Epub 2021 Sep 30. Clin Cancer Res. 2021. PMID: 34593526 Free PMC article. Clinical Trial.

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Therapeutic plasma exchange clears circulating soluble PD-L1 and PD-L1-positive extracellular vesicles.

Orme JJ, Enninga EAL, Lucien-Matteoni F, Dale H, Burgstaler E, Harrington SM, Ball MK, Mansfield AS, Park SS, Block MS, Markovic SN, Yan Y, Dong H, Dronca RS, Winters JL. Orme JJ, et al. J Immunother Cancer. 2020 Aug;8(2):e001113. doi: 10.1136/jitc-2020-001113. J Immunother Cancer. 2020. PMID: 32817395 Free PMC article.

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