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Year Number of Results
2014 1
2015 2
2017 2
2018 3
2019 1
2020 1
2021 4
2022 0
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12 results
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Anticancer opportunities at every stage of chemokine function.
Ortiz Zacarías NV, Bemelmans MP, Handel TM, de Visser KE, Heitman LH. Ortiz Zacarías NV, et al. Trends Pharmacol Sci. 2021 Nov;42(11):912-928. doi: 10.1016/j.tips.2021.08.001. Epub 2021 Sep 11. Trends Pharmacol Sci. 2021. PMID: 34521537 Review.
Intracellular Receptor Modulation: Novel Approach to Target GPCRs.
Ortiz Zacarías NV, Lenselink EB, IJzerman AP, Handel TM, Heitman LH. Ortiz Zacarías NV, et al. Trends Pharmacol Sci. 2018 Jun;39(6):547-559. doi: 10.1016/j.tips.2018.03.002. Epub 2018 Apr 10. Trends Pharmacol Sci. 2018. PMID: 29653834 Free PMC article. Review.
Colistin: Revival of an Old Polymyxin Antibiotic.
Dijkmans AC, Wilms EB, Kamerling IM, Birkhoff W, Ortiz-Zacarías NV, van Nieuwkoop C, Verbrugh HA, Touw DJ. Dijkmans AC, et al. Among authors: ortiz zacarias nv. Ther Drug Monit. 2015 Aug;37(4):419-27. doi: 10.1097/FTD.0000000000000172. Ther Drug Monit. 2015. PMID: 25549206 Review.
Piperazine squaric acid diamides, a novel class of allosteric P2X7 receptor antagonists.
Patberg M, Isaak A, Füsser F, Ortiz Zacarías NV, Vinnenberg L, Schulte J, Michetti L, Grey L, van der Horst C, Hundehege P, Koch O, Heitman LH, Budde T, Junker A. Patberg M, et al. Among authors: ortiz zacarias nv. Eur J Med Chem. 2021 Dec 15;226:113838. doi: 10.1016/j.ejmech.2021.113838. Epub 2021 Sep 16. Eur J Med Chem. 2021. PMID: 34571173
Design and Characterization of an Intracellular Covalent Ligand for CC Chemokine Receptor 2.
Ortiz Zacarías NV, Chahal KK, Šimková T, van der Horst C, Zheng Y, Inoue A, Theunissen E, Mallee L, van der Es D, Louvel J, IJzerman AP, Handel TM, Kufareva I, Heitman LH. Ortiz Zacarías NV, et al. J Med Chem. 2021 Mar 11;64(5):2608-2621. doi: 10.1021/acs.jmedchem.0c01137. Epub 2021 Feb 18. J Med Chem. 2021. PMID: 33600174 Free PMC article.
Development of the First Potential Nonpeptidic Positron Emission Tomography Tracer for the Imaging of CCR2 Receptors.
Wagner S, de Moura Gatti F, Silva DG, Ortiz Zacarias NV, Zweemer AJM, Hermann S, De Maria M, Koch M, Weiss C, Schepmann D, Heitman LH, Tschammer N, Kopka K, Junker A. Wagner S, et al. Among authors: ortiz zacarias nv. ChemMedChem. 2021 Feb 17;16(4):640-645. doi: 10.1002/cmdc.202000728. Epub 2020 Nov 23. ChemMedChem. 2021. PMID: 33205603 Free PMC article.
Synthesis and biological evaluation of chemokine receptor ligands with 2-benzazepine scaffold.
Thum S, Kokornaczyk AK, Seki T, De Maria M, Ortiz Zacarias NV, de Vries H, Weiss C, Koch M, Schepmann D, Kitamura M, Tschammer N, Heitman LH, Junker A, Wünsch B. Thum S, et al. Among authors: ortiz zacarias nv. Eur J Med Chem. 2017 Jul 28;135:401-413. doi: 10.1016/j.ejmech.2017.04.046. Epub 2017 Apr 22. Eur J Med Chem. 2017. PMID: 28463783
Pyrrolone Derivatives as Intracellular Allosteric Modulators for Chemokine Receptors: Selective and Dual-Targeting Inhibitors of CC Chemokine Receptors 1 and 2.
Ortiz Zacarías NV, van Veldhoven JPD, Portner L, van Spronsen E, Ullo S, Veenhuizen M, van der Velden WJC, Zweemer AJM, Kreekel RM, Oenema K, Lenselink EB, Heitman LH, IJzerman AP. Ortiz Zacarías NV, et al. J Med Chem. 2018 Oct 25;61(20):9146-9161. doi: 10.1021/acs.jmedchem.8b00605. Epub 2018 Oct 11. J Med Chem. 2018. PMID: 30256641 Free PMC article.
Sodium ion binding pocket mutations and adenosine A2A receptor function.
Massink A, Gutiérrez-de-Terán H, Lenselink EB, Ortiz Zacarías NV, Xia L, Heitman LH, Katritch V, Stevens RC, IJzerman AP. Massink A, et al. Among authors: ortiz zacarias nv. Mol Pharmacol. 2015 Feb;87(2):305-13. doi: 10.1124/mol.114.095737. Epub 2014 Dec 3. Mol Pharmacol. 2015. PMID: 25473121 Free PMC article.
12 results