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Testo and testo-Pt(II) bind DNA at different locations.
Chanphai P, Ouellette V, Mandal SK, Bérubé G, Tajmir-Riahi HA. Chanphai P, et al. Among authors: ouellette v. Chem Biol Interact. 2018 Dec 25;296:179-184. doi: 10.1016/j.cbi.2018.09.008. Epub 2018 Sep 22. Chem Biol Interact. 2018. PMID: 30253125
Homologation of the Alkyl Side Chain of Antimitotic Phenyl 4-(2-Oxo-3-alkylimidazolidin-1-yl)benzenesulfonate Prodrugs Selectively Targeting CYP1A1-Expressing Breast Cancers Improves Their Stability in Rodent Liver Microsomes.
Chavez Alvarez AC, Bouzriba C, Moreau E, Auzeloux P, Besse S, Ouellette V, Zarifi Khosroshahi M, Côté MF, Pilote S, Miot-Noirault E, Chezal JM, Simard C, C-Gaudreault R, Fortin S. Chavez Alvarez AC, et al. Among authors: ouellette v. J Med Chem. 2023 Feb 23;66(4):2477-2497. doi: 10.1021/acs.jmedchem.2c01268. Epub 2023 Feb 13. J Med Chem. 2023. PMID: 36780426
Branched alkyl of phenyl 4-(2-oxo-3-alkylimidazolidin-1-yl)benzenesulfonates as unique cytochrome P450 1A1-activated antimitotic prodrugs: Biological evaluation and mechanism of bioactivation.
Bouzriba C, Chavez Alvarez AC, Gagné-Boulet M, Ouellette V, Lacroix J, Côté MF, C-Gaudreault R, Fortin S. Bouzriba C, et al. Among authors: ouellette v. Eur J Med Chem. 2022 Feb 5;229:114003. doi: 10.1016/j.ejmech.2021.114003. Epub 2021 Nov 19. Eur J Med Chem. 2022. PMID: 34839998
Location of multiple binding sites for testo and testo-Pt(II) with tRNA.
Chanphai P, Ouellette V, Mandal S, Mandal SK, Bérubé G, Tajmir-Riahi HA. Chanphai P, et al. Among authors: ouellette v. J Biomol Struct Dyn. 2019 Oct;37(16):4133-4139. doi: 10.1080/07391102.2018.1541142. Epub 2018 Dec 24. J Biomol Struct Dyn. 2019. PMID: 30417741
19 results