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Page 1
Repurposed Antiviral Drugs for Covid-19 - Interim WHO Solidarity Trial Results.
WHO Solidarity Trial Consortium; Pan H, Peto R, Henao-Restrepo AM, Preziosi MP, Sathiyamoorthy V, Abdool Karim Q, Alejandria MM, Hernández García C, Kieny MP, Malekzadeh R, Murthy S, Reddy KS, Roses Periago M, Abi Hanna P, Ader F, Al-Bader AM, Alhasawi A, Allum E, Alotaibi A, Alvarez-Moreno CA, Appadoo S, Asiri A, Aukrust P, Barratt-Due A, Bellani S, Branca M, Cappel-Porter HBC, Cerrato N, Chow TS, Como N, Eustace J, García PJ, Godbole S, Gotuzzo E, Griskevicius L, Hamra R, Hassan M, Hassany M, Hutton D, Irmansyah I, Jancoriene L, Kirwan J, Kumar S, Lennon P, Lopardo G, Lydon P, Magrini N, Maguire T, Manevska S, Manuel O, McGinty S, Medina MT, Mesa Rubio ML, Miranda-Montoya MC, Nel J, Nunes EP, Perola M, Portolés A, Rasmin MR, Raza A, Rees H, Reges PPS, Rogers CA, Salami K, Salvadori MI, Sinani N, Sterne JAC, Stevanovikj M, Tacconelli E, Tikkinen KAO, Trelle S, Zaid H, Røttingen JA, Swaminathan S. WHO Solidarity Trial Consortium, et al. N Engl J Med. 2021 Feb 11;384(6):497-511. doi: 10.1056/NEJMoa2023184. Epub 2020 Dec 2. N Engl J Med. 2021. PMID: 33264556 Free PMC article. Clinical Trial.
Death occurred in 301 of 2743 patients receiving remdesivir and in 303 of 2708 receiving its control (rate ratio, 0.95; 95% confidence interval [CI], 0.81 to 1.11; P = 0.50), in 104 of 947 patients receiving hydroxychloroquine and in 84 of 906 receiving its control (rate r …
Death occurred in 301 of 2743 patients receiving remdesivir and in 303 of 2708 receiving its control (rate ratio, 0.95; 95% confidence inter …
A new molecular classification to drive precision treatment strategies in primary Sjögren's syndrome.
Soret P, Le Dantec C, Desvaux E, Foulquier N, Chassagnol B, Hubert S, Jamin C, Barturen G, Desachy G, Devauchelle-Pensec V, Boudjeniba C, Cornec D, Saraux A, Jousse-Joulin S, Barbarroja N, Rodríguez-Pintó I, De Langhe E, Beretta L, Chizzolini C, Kovács L, Witte T; PRECISESADS Clinical Consortium; PRECISESADS Flow Cytometry Consortium; Bettacchioli E, Buttgereit A, Makowska Z, Lesche R, Borghi MO, Martin J, Courtade-Gaiani S, Xuereb L, Guedj M, Moingeon P, Alarcón-Riquelme ME, Laigle L, Pers JO. Soret P, et al. Nat Commun. 2021 Jun 10;12(1):3523. doi: 10.1038/s41467-021-23472-7. Nat Commun. 2021. PMID: 34112769 Free PMC article.
Testing random effects in linear mixed-effects models with serially correlated errors.
Drikvandi R, Noorian S. Drikvandi R, et al. Biom J. 2019 Jul;61(4):802-812. doi: 10.1002/bimj.201700203. Epub 2019 Feb 5. Biom J. 2019. PMID: 30721539
Our permutation procedure includes the permutation procedure in Drikvandi, Verbeke, Khodadadi, and Partovi Nia (2013) as a special case when errors are i.i.d., though the test statistics are different. ...
Our permutation procedure includes the permutation procedure in Drikvandi, Verbeke, Khodadadi, and Partovi Nia (2013) as a special ca …
The efficacy of DASH combined with time-restricted feeding (16/8) on metabolic associated fatty liver disease management: a randomized controlled trial.
Nilghaz M, Sadeghi A, Koochakpoor G, Poustchi H, Khodadadi N, Narimani B, Ghods M, Shafiee M, Shahparvari MR, Hekmatdoost A. Nilghaz M, et al. Sci Rep. 2025 Feb 27;15(1):7020. doi: 10.1038/s41598-025-88393-7. Sci Rep. 2025. PMID: 40016311 Free PMC article. Clinical Trial.

The TRF plus DASH diet reduced body mass index (p = 0.03), abdominal circumference (p = 0.005), controlled attenuation parameter (CAP) (p < 0.001), alanine aminotransferase (p = 0.039), and aspartate aminotransferase (0.047) compared to the control

The TRF plus DASH diet reduced body mass index (p = 0.03), abdominal circumference (p = 0.005), controlled attenuation paramet …
Remdesivir and three other drugs for hospitalised patients with COVID-19: final results of the WHO Solidarity randomised trial and updated meta-analyses.
WHO Solidarity Trial Consortium. WHO Solidarity Trial Consortium. Lancet. 2022 May 21;399(10339):1941-1953. doi: 10.1016/S0140-6736(22)00519-0. Epub 2022 May 2. Lancet. 2022. PMID: 35512728 Free PMC article.
Of those not ventilated but on oxygen, 14.6% assigned to remdesivir died versus 16.3% assigned to control (RR 0.87 [0.76-0.99], p=0.03). Of 1730 not on oxygen initially, 2.9% assigned to remdesivir died versus 3.8% assigned to control (RR 0.76 [0.46-1.28], p=0.30). …
Of those not ventilated but on oxygen, 14.6% assigned to remdesivir died versus 16.3% assigned to control (RR 0.87 [0.76-0.99], p=0.0 …
Optimization of seizure prevention by cannabidiol (CBD).
Bhandari B, Naeini SE, Rezaee S, Rogers HM, Khodadadi H, Bosomtwi A, Seyyedi M, MacKinnon NJ, Dhandapani KM, Salles ÉL, Hess DC, Yu JC, Moore-Hill D, Vale FL, Wang LP, Baban B. Bhandari B, et al. Transl Neurosci. 2025 Mar 28;16(1):20220362. doi: 10.1515/tnsci-2022-0362. eCollection 2025 Jan 1. Transl Neurosci. 2025. PMID: 40177581 Free PMC article.

Among the combination of CBD tested, CBD broad spectrum via inhalation was the most effective in the treatment of epileptic seizures (p < 0.05) compared to other forms of CBD treatments. CONCLUSION: Our data suggest that route and CBD formulations affect its efficacy in

Among the combination of CBD tested, CBD broad spectrum via inhalation was the most effective in the treatment of epileptic seizures (p
Vitamin D3 Supplementation Modulates Inflammatory Protein CHI3L1/YKL-40 and Oxidative Stress Status in Multiple Sclerosis.
Asadpour S, Mazdeh M, Karimi J, Khodadadi I, Shafiee G. Asadpour S, et al. Neuropsychopharmacol Rep. 2025 Dec;45(4):e70076. doi: 10.1002/npr2.70076. Neuropsychopharmacol Rep. 2025. PMID: 41277171 Free PMC article. Clinical Trial.

/L; p < 0.001) and MDA (0.08 0.03 to 0.05 0.026 nmol/mL; p < 0.001). Antioxidant capacity improved, as demonstrated by elevated TAC (0.622 0.138 to 0.797 0.15 mmol Fe(2+)/L; p < 0.001) and increased activities of SOD (10.5%; p < 0.0

/L; p < 0.001) and MDA (0.08 0.03 to 0.05 0.026 nmol/mL; p < 0.001). Antioxidant capacity improved, as demonstrated

Spinal Cord Tau and Protein Copathologies Associated With Chronic Traumatic Encephalopathy.
Tanaka H, Black LE, Forrest SL, Danics K, Sadia N, Khodadadi M, Tator C, Smith DH, Tartaglia MC, Stewart W, Kovacs GG. Tanaka H, et al. JAMA Neurol. 2026 Mar 1;83(3):231-241. doi: 10.1001/jamaneurol.2025.5421. JAMA Neurol. 2026. PMID: 41587040 Free PMC article.
All cases with CTE-NC exhibited spinal cord p-tau deposits, especially in cases aged 65 years or older with prior RHI (n = 14), often showing extensive spinal tau pathology as both neuronal (all 14 cases) and astrocytic (12 of 14 cases [86%]) p-tau deposits. ...In t …
All cases with CTE-NC exhibited spinal cord p-tau deposits, especially in cases aged 65 years or older with prior RHI (n = 14), often …
Misfolded α-Synuclein in Cerebrospinal Fluid of Contact Sport Athletes.
Vasilevskaya A, Martinez-Valbuena I, Anastassiadis C, Taghdiri F, Khodadadi M, Tarazi A, Green R, Colella B, Wennberg R, Mikulis D, Davis KD, Kovacs GG, Tator C, Tartaglia MC. Vasilevskaya A, et al. Mov Disord. 2023 Nov;38(11):2125-2131. doi: 10.1002/mds.29621. Epub 2023 Oct 4. Mov Disord. 2023. PMID: 37792643
METHODS: Thirty former athletes with magnetic resonance imaging, neuropsychological testing, and CSF analyzed for phosphorylated tau 181 (p-tau), total tau (t-tau), amyloid-beta 42 (Abeta42), and neurofilament light chain (NfL). ...RESULTS: Six (20%) former athletes were a …
METHODS: Thirty former athletes with magnetic resonance imaging, neuropsychological testing, and CSF analyzed for phosphorylated tau 181 ( …
Niacin modulates macrophage polarization in Parkinson's disease.
Wakade C, Giri B, Malik A, Khodadadi H, Morgan JC, Chong RK, Baban B. Wakade C, et al. J Neuroimmunol. 2018 Jul 15;320:76-79. doi: 10.1016/j.jneuroim.2018.05.002. Epub 2018 May 4. J Neuroimmunol. 2018. PMID: 29759143 Free article. Clinical Trial.
276 results