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Methoxyhispolon Methyl Ether, a Hispolon Analog, Thwarts the SRC/STAT3/BCL-2 Axis to Provoke Human Triple-Negative Breast Cancer Cell Apoptosis In Vitro.
Liao CP, Hsieh YC, Lu CH, Dai WC, Yang WT, Cheng KT, Ramani MV, Subbaraju GV, Chang CC. Liao CP, et al. Biomedicines. 2023 Oct 10;11(10):2742. doi: 10.3390/biomedicines11102742. Biomedicines. 2023. PMID: 37893115 Free PMC article.
Mechanistically, MHME suppressed both constitutive and interleukin 6 (IL-6)-induced activation of STAT3 represented by the extent of tyrosine 705-phosphorylated STAT3 (p-STAT3). Notably, MHME-evoked apoptosis and clonogenicity impairment were abrogated in TNBC cells overex …
Mechanistically, MHME suppressed both constitutive and interleukin 6 (IL-6)-induced activation of STAT3 represented by the extent of tyrosin …
Blockade of the SRC/STAT3/BCL-2 Signaling Axis Sustains the Cytotoxicity in Human Colorectal Cancer Cell Lines Induced by Dehydroxyhispolon Methyl Ether.
Hsieh YC, Dai YC, Cheng KT, Yang WT, Ramani MV, Subbaraju GV, Chen YJ, Chang CC. Hsieh YC, et al. Biomedicines. 2023 Sep 13;11(9):2530. doi: 10.3390/biomedicines11092530. Biomedicines. 2023. PMID: 37760971 Free PMC article.
DHME suppressed both constitutive and interleukin 6 (IL-6)-induced STAT3 activation represented by tyrosine 705 phosphorylation of STAT3 (p-STAT3 (Y705)); notably, DHME-induced CRC apoptosis and clonogenicity limitation were abrogated by ectopic expression of STAT3-C, a do …
DHME suppressed both constitutive and interleukin 6 (IL-6)-induced STAT3 activation represented by tyrosine 705 phosphorylation of STAT3 ( …
The in vitro antitumor activity of arene-ruthenium(II) curcuminoid complexes improves when decreasing curcumin polarity.
Caruso F, Pettinari R, Rossi M, Monti E, Gariboldi MB, Marchetti F, Pettinari C, Caruso A, Ramani MV, Subbaraju GV. Caruso F, et al. J Inorg Biochem. 2016 Sep;162:44-51. doi: 10.1016/j.jinorgbio.2016.06.002. Epub 2016 Jun 4. J Inorg Biochem. 2016. PMID: 27293144
These activities are improved when compared to the already known corresponding curcumin complex, (p-cymene)Ru(curcuminato)Cl, about twice for the breast and ovarian cancer, 4.7 times stronger in the lung cancer and about 6.6 times stronger in the glioblastoma cell lines. I …
These activities are improved when compared to the already known corresponding curcumin complex, (p-cymene)Ru(curcuminato)Cl, about t …
New acylated iridoid glucosides from Vitex altissima.
Sridhar C, Subbaraju GV, Venkateswarlu Y, Venugopal RT. Sridhar C, et al. J Nat Prod. 2004 Dec;67(12):2012-6. doi: 10.1021/np040117r. J Nat Prod. 2004. PMID: 15620243
Six new iridoid glucosides, 6'-O-trans-feruloylnegundoside (1), 6'-O-trans-caffeoylnegundoside (2), 2'-O-p-hydroxybenzoyl-6'-O-trans-caffeoylgardoside (3), 2'-O-p-hydroxybenzoyl-6'-O-trans-caffeoyl-8-epiloganic acid (4), 2'-O-p-hydroxybenzoyl gardoside (5), a …
Six new iridoid glucosides, 6'-O-trans-feruloylnegundoside (1), 6'-O-trans-caffeoylnegundoside (2), 2'-O-p-hydroxybenzoyl-6'-O-trans- …
Three new cryptophycins from Nostoc sp. GSV 224.
Subbaraju GV, Golakoti T, Patterson GM, Moore RE. Subbaraju GV, et al. J Nat Prod. 1997 Mar;60(3):302-5. doi: 10.1021/np960700a. J Nat Prod. 1997. PMID: 9090872
Flavonoids, triterpenoids and a lignan from Vitex altissima.
Sridhar C, Rao KV, Subbaraju GV. Sridhar C, et al. Phytochemistry. 2005 Jul;66(14):1707-12. doi: 10.1016/j.phytochem.2005.05.008. Phytochemistry. 2005. PMID: 15963541
A new tetrahydrofuranoid lignan, altissinone (1) and a new acylated flavone C-glucoside, 2''-O-p-hydroxybenzoylorientin (2), were isolated in addition to several known triterpene acids and flavonoids from the ethyl acetate extractives of the leaves of Vitex altissima. ...
A new tetrahydrofuranoid lignan, altissinone (1) and a new acylated flavone C-glucoside, 2''-O-p-hydroxybenzoylorientin (2), were iso …
Design, synthesis and in vitro cell-based evaluation of the anti-cancer activities of hispolon analogs.
Balaji NV, Ramani MV, Viana AG, Sanglard LP, White J, Mulabagal V, Lee C, Gana TJ, Egiebor NO, Subbaraju GV, Tiwari AK. Balaji NV, et al. Bioorg Med Chem. 2015 May 1;23(9):2148-2158. doi: 10.1016/j.bmc.2015.03.002. Epub 2015 Mar 21. Bioorg Med Chem. 2015. PMID: 25842364 Free PMC article.
Among the hispolon analogs tested, compound VA-2, the most potent overall, produced its most significant effect in the colon cancer cell lines HCT-116 (IC50 1.4 1.3 muM) and S1 (IC50 1.8 0.9 muM) compared to its activity in the normal HEK293/pcDNA3.1 cell line (IC50 15.83.7 muM; …
Among the hispolon analogs tested, compound VA-2, the most potent overall, produced its most significant effect in the colon cancer cell lin …