Design, synthesis and in vitro cell-based evaluation of the anti-cancer activities of hispolon analogs.
Balaji NV, Ramani MV, Viana AG, Sanglard LP, White J, Mulabagal V, Lee C, Gana TJ, Egiebor NO, Subbaraju GV, Tiwari AK.
Balaji NV, et al.
Bioorg Med Chem. 2015 May 1;23(9):2148-2158. doi: 10.1016/j.bmc.2015.03.002. Epub 2015 Mar 21.
Bioorg Med Chem. 2015.
PMID: 25842364
Free PMC article.
Among the hispolon analogs tested, compound VA-2, the most potent overall, produced its most significant effect in the colon cancer cell lines HCT-116 (IC50 1.4 1.3 muM) and S1 (IC50 1.8 0.9 muM) compared to its activity in the normal HEK293/pcDNA3.1 cell line (IC50 15.8 3.7 …
Among the hispolon analogs tested, compound VA-2, the most potent overall, produced its most significant effect in the colon cancer cell lin …