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Effects of maternal diet-induced obesity on metabolic disorders and age-associated miRNA expression in the liver of male mouse offspring.
Mennitti LV, Carpenter AAM, Loche E, Pantaleão LC, Fernandez-Twinn DS, Schoonejans JM, Blackmore HL, Ashmore TJ, Pisani LP, Tadross JA, Hargreaves I, Ozanne SE. Mennitti LV, et al. Int J Obes (Lond). 2022 Feb;46(2):269-278. doi: 10.1038/s41366-021-00985-1. Epub 2021 Oct 18. Int J Obes (Lond). 2022. PMID: 34663892 Free PMC article.

RESULTS: Body weight and composition was similar between 8-week-old offspring, however, 12-month-old offspring from obese mothers had increased body weight and fat mass (19.5 0.8 g versus 10.4 0.9 g, p < 0.001), as well as elevated serum levels of LDL and

RESULTS: Body weight and composition was similar between 8-week-old offspring, however, 12-month-old offspring from obese mothers had increa …
Chronic gestational hypoxia accelerates ovarian aging and lowers ovarian reserve in next-generation adult rats.
Aiken CE, Tarry-Adkins JL, Spiroski AM, Nuzzo AM, Ashmore TJ, Rolfo A, Sutherland MJ, Camm EJ, Giussani DA, Ozanne SE. Aiken CE, et al. FASEB J. 2019 Jun;33(6):7758-7766. doi: 10.1096/fj.201802772R. Epub 2019 Mar 19. FASEB J. 2019. PMID: 30888848 Free PMC article.

Female rats exposed to chronic gestational hypoxia (13%) during their intrauterine development had decreased ovarian primordial follicular reserve compared to controls (P < 0.05). Adult females who had been exposed to chronic fetal hypoxia had significantly reduced soma

Female rats exposed to chronic gestational hypoxia (13%) during their intrauterine development had decreased ovarian primordial follicular r …
Natural Protein Intake in Children with Phenylketonuria: Prescription vs. Actual Intakes.
Pinto A, Daly A, Rocha JC, Ashmore C, Evans S, Ilgaz F, Hickson M, MacDonald A. Pinto A, et al. Nutrients. 2023 Nov 23;15(23):4903. doi: 10.3390/nu15234903. Nutrients. 2023. PMID: 38068761 Free PMC article.
Any foods containing protein 0.5 g/100 g or fruits/vegetables containing Phe 75 mg/100 g are allowed without measurement or limit. ...The median difference between the prescribed and actual natural protein daily intakes was +4 g/day (range: -2.5 to +11 …
Any foods containing protein 0.5 g/100 g or fruits/vegetables containing Phe 75 mg/100 g are allowed without measuremen …
Impact of Fruit and Vegetable Protein vs. Milk Protein on Metabolic Control of Children with Phenylketonuria: A Randomized Crossover Controlled Trial.
Pinto A, Daly A, Rocha JC, Ashmore C, Evans S, Jackson R, Payne A, Hickson M, MacDonald A. Pinto A, et al. Nutrients. 2022 Oct 13;14(20):4268. doi: 10.3390/nu14204268. Nutrients. 2022. PMID: 36296952 Free PMC article. Clinical Trial.
Sixteen patients (median age 10.5 y; range 612 y) were recruited. At baseline, a median of 6 g/day (range: 325) natural protein and 60 g/day (range: 6080) protein equivalent from protein substitute were prescribed. ...There was a trend that vegetable protein had les …
Sixteen patients (median age 10.5 y; range 612 y) were recruited. At baseline, a median of 6 g/day (range: 325) natural protein and 6 …
Casein Glycomacropeptide: An Alternative Protein Substitute in Tyrosinemia Type I.
Daly A, Evans S, Pinto A, Ashmore C, MacDonald A. Daly A, et al. Nutrients. 2021 Sep 16;13(9):3224. doi: 10.3390/nu13093224. Nutrients. 2021. PMID: 34579102 Free PMC article.
The median daily dose of protein equivalent from protein substitute was 60 g/day (range 45-60 g) with a median of 20 g/day (range 15 to 30 g) from natural protein. ...
The median daily dose of protein equivalent from protein substitute was 60 g/day (range 45-60 g) with a median of 20 g/ …
Preliminary Data on Free Use of Fruits and Vegetables Containing Phenylalanine 76-100 mg/100 g of Food in 16 Children with Phenylketonuria: 6 Months Follow-Up.
Pinto A, Daly A, Rocha JC, Ashmore C, Evans S, Jackson R, Hickson M, MacDonald A. Pinto A, et al. Nutrients. 2023 Jul 6;15(13):3046. doi: 10.3390/nu15133046. Nutrients. 2023. PMID: 37447372 Free PMC article.
In the extension study, the patients had an actual mean intake of 11 g/day (4-37) natural protein and 65 g/day (60-80) protein equivalent from a protein substitute. The mean phenylalanine intake was 563 mg/day (200-1850) with only 19 mg/day (0-146) phenylalanine fro …
In the extension study, the patients had an actual mean intake of 11 g/day (4-37) natural protein and 65 g/day (60-80) protein …
Impact on Diet Quality and Burden of Care in Sapropterin Dihydrochloride Use in Children with Phenylketonuria: A 6 Month Follow-Up Report.
Gama MI, Daly A, Ashmore C, Evans S, Moreira-Rosário A, Rocha JC, MacDonald A. Gama MI, et al. Nutrients. 2023 Aug 17;15(16):3603. doi: 10.3390/nu15163603. Nutrients. 2023. PMID: 37630793 Free PMC article.
There were increases in regular cow's milk (p = 0.001), meat/fish, eggs (p = 0.005), bread (p = 0.01) and pasta (p = 0.011) intakes but special low-protein foods intake decreased. Anxiety (p = 0.016) and depression (p = 0.022) decreased i …
There were increases in regular cow's milk (p = 0.001), meat/fish, eggs (p = 0.005), bread (p = 0.01) and pasta (p
Uniformity of Food Protein Interpretation Amongst Dietitians for Patients with Phenylketonuria (PKU): 2020 UK National Consensus Statements.
Evans S, Adam S, Adams S, Allen H, Ashmore C, Bailey S, Banks J, Churchill H, Cochrane B, Cook J, Dale C, Daly A, Dixon M, Dunlop C, Ellerton C, Emm A, Firman S, Ford S, French M, Gribben J, Grimsley A, Herlihy I, Hill M, Judd S, Lang K, Males J, McDonald J, McStravick N, Millington C, Newby C, Noble C, Pereira R, Pinto A, Robertson L, Robotham A, Ross K, Singleton K, Skeath R, Terry A, Van Wyk K, White F, White L, Wildgoose J, Woodall A, MacDonald A. Evans S, et al. Nutrients. 2020 Jul 24;12(8):2205. doi: 10.3390/nu12082205. Nutrients. 2020. PMID: 32722073 Free PMC article.
Statements encompassed all foods/food groups divided into four categories based on defined protein/phenylalanine content: (1) foods high in protein/phenylalanine (best avoided); (2) foods allowed without restriction including fruit/vegetables containing phenylalanine 75 mg/100 …
Statements encompassed all foods/food groups divided into four categories based on defined protein/phenylalanine content: (1) foods high in …
Association Studies of HFE C282Y and H63D Variants with Oral Cancer Risk and Iron Homeostasis Among Whites and Blacks.
Jones NR, Ashmore JH, Lee SY, Richie JP, Lazarus P, Muscat JE. Jones NR, et al. Cancers (Basel). 2015 Dec 9;7(4):2386-96. doi: 10.3390/cancers7040898. Cancers (Basel). 2015. PMID: 26690219 Free PMC article.
RESULTS: Individuals with the C282Y allele had lower total iron binding capacity (TIBC) (321.2 37.2 g/dL vs. 397.7 89.0 g/dL, p = 0.007) and higher percent transferrin saturation (22.0 8.7 vs. 35.6 22.9, p = 0.023) than wild type individuals. Iron and …
RESULTS: Individuals with the C282Y allele had lower total iron binding capacity (TIBC) (321.2 37.2 g/dL vs. 397.7 89.0 g/dL, …
29 results