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P3h3-null and Sc65-null Mice Phenocopy the Collagen Lysine Under-hydroxylation and Cross-linking Abnormality of Ehlers-Danlos Syndrome Type VIA.
Hudson DM, Weis M, Rai J, Joeng KS, Dimori M, Lee BH, Morello R, Eyre DR. Hudson DM, et al. J Biol Chem. 2017 Mar 3;292(9):3877-3887. doi: 10.1074/jbc.M116.762245. Epub 2017 Jan 23. J Biol Chem. 2017. PMID: 28115524 Free PMC article.
Furthermore, the ratio of mature HP/LP cross-links in bone of both P3h3(-/-) and Sc65(-/-) mice was reversed compared with wild type, consistent with the level of lysine under-hydroxylation seen in individual chains at cross-linking sites. The effect on cross-linking lysin …
Furthermore, the ratio of mature HP/LP cross-links in bone of both P3h3(-/-) and Sc65(-/-) mice was reversed compared with wild type, …
Identifying Immune Cell Infiltration and Hub Genes During the Myocardial Remodeling Process After Myocardial Infarction.
Tian Y, Wang Z, Liang F, Wang Y. Tian Y, et al. J Inflamm Res. 2023 Jul 11;16:2893-2906. doi: 10.2147/JIR.S416914. eCollection 2023. J Inflamm Res. 2023. PMID: 37456781 Free PMC article.
The snRNA-seq data analyzed that P3h3, Col15a1, Col16a1, and Col27a1 were highly expressed in fibroblasts of post-MI. CONCLUSION: This study identified four hub genes P3H3, COL15A1, COL16A1, and COL27A1, particularly P3H3, as potential targets for targeted th …
The snRNA-seq data analyzed that P3h3, Col15a1, Col16a1, and Col27a1 were highly expressed in fibroblasts of post-MI. CONCLUSION: Thi …
The prolyl 3-hydroxylases P3H2 and P3H3 are novel targets for epigenetic silencing in breast cancer.
Shah R, Smith P, Purdie C, Quinlan P, Baker L, Aman P, Thompson AM, Crook T. Shah R, et al. Br J Cancer. 2009 May 19;100(10):1687-96. doi: 10.1038/sj.bjc.6605042. Br J Cancer. 2009. PMID: 19436308 Free PMC article.
Expression of P3H2 (Leprel1) and P3H3 (Leprel2) but not P3H1 (Leprecan) is down-regulated in breast cancer by aberrant CpG methylation in the 5' regulatory sequences of each gene. ...Ectopic expression of P3H2 and P3H3 in cell lines with silencing of the endogenous …
Expression of P3H2 (Leprel1) and P3H3 (Leprel2) but not P3H1 (Leprecan) is down-regulated in breast cancer by aberrant CpG methylatio …
Collagen prolyl hydroxylase 3 has a tumor suppressive activity in human lung cancer.
Li Y, Chen Y, Ma Y, Nenkov M, Haase D, Petersen I. Li Y, et al. Exp Cell Res. 2018 Feb 1;363(1):121-128. doi: 10.1016/j.yexcr.2017.12.020. Epub 2017 Dec 23. Exp Cell Res. 2018. PMID: 29277505
However the role of P3H3 in lung cancer has not yet been elucidated. In this study, we analyzed P3H3 expression in a panel of lung cancer cell lines and primary lung tumors. ...We found that P3H3 was downregulated in 6 out of 10 lung cancer cell lines. A hete …
However the role of P3H3 in lung cancer has not yet been elucidated. In this study, we analyzed P3H3 expression in a panel of …
Type I and type V procollagen triple helix uses different subsets of the molecular ensemble for lysine posttranslational modifications in the rER.
Ishikawa Y, Taga Y, Zientek K, Mizuno N, Salo AM, Semenova O, Tufa SF, Keene DR, Holden P, Mizuno K, Gould DB, Myllyharju J, Bächinger HP. Ishikawa Y, et al. J Biol Chem. 2021 Jan-Jun;296:100453. doi: 10.1016/j.jbc.2021.100453. Epub 2021 Feb 23. J Biol Chem. 2021. PMID: 33631195 Free PMC article.
If P3H3 is an LH1 chaperone that is critical for LH1 activity, P3H3 and LH1 null mice should display a similar deficiency in lysyl hydroxylation. To test this hypothesis, we compared the amount and location of hydroxylysine in the triple helical domains of type V an …
If P3H3 is an LH1 chaperone that is critical for LH1 activity, P3H3 and LH1 null mice should display a similar deficiency in l …
Collagen prolyl 3-hydroxylation: a major role for a minor post-translational modification?
Hudson DM, Eyre DR. Hudson DM, et al. Connect Tissue Res. 2013;54(4-5):245-51. doi: 10.3109/03008207.2013.800867. Epub 2013 Jun 21. Connect Tissue Res. 2013. PMID: 23772978 Free PMC article. Review.
P3H1 is part of a family of gene products that also includes isoenzymes P3H2 and P3H3 as well as CRTAP and Sc65. It is believed these isoenzymes and coenzyme proteins have evolved different collagen substrate site and tissue specificities in their activities. ...
P3H1 is part of a family of gene products that also includes isoenzymes P3H2 and P3H3 as well as CRTAP and Sc65. It is believed these …
Identification of cuproptosis-related genes and immune infiltration in dilated cardiomyopathy.
Lin Y, Chen K, Guo J, Chen P, Qian ZR, Zhang T. Lin Y, et al. Int J Cardiol. 2024 Mar 15;399:131702. doi: 10.1016/j.ijcard.2023.131702. Epub 2023 Dec 31. Int J Cardiol. 2024. PMID: 38168558
A diagnostic model made up of six signature genes including SEPTIN1, CLEC11A, ISG15, P3H3, SDSL, and INKA1 was selected. Furthermore, immune infiltration studies showed significant differences between DCM and NF. Drugs networks and ceRNA regulatory network based on six sig …
A diagnostic model made up of six signature genes including SEPTIN1, CLEC11A, ISG15, P3H3, SDSL, and INKA1 was selected. Furthermore, …
A cohort-based study of host gene expression: tumor suppressor and innate immune/inflammatory pathways associated with the HIV reservoir size.
Dwivedi AK, Gornalusse GG, Siegel DA, Barbehenn A, Thanh C, Hoh R, Hobbs KS, Pan T, Gibson EA, Martin J, Hecht F, Pilcher C, Milush J, Busch MP, Stone M, Huang ML, Reppetti J, Vo PM, Levy CN, Roychoudhury P, Jerome KR, Hladik F, Henrich TJ, Deeks SG, Lee SA. Dwivedi AK, et al. PLoS Pathog. 2023 Nov 29;19(11):e1011114. doi: 10.1371/journal.ppat.1011114. eCollection 2023 Nov. PLoS Pathog. 2023. PMID: 38019897 Free PMC article.
After adjusting for nadir CD4+ count, timing of ART initiation, and genetic ancestry, we identified two host genes for which higher expression was significantly associated with smaller total DNA viral reservoir size, P3H3 and NBL1, both known tumor suppressor genes. We the …
After adjusting for nadir CD4+ count, timing of ART initiation, and genetic ancestry, we identified two host genes for which higher expressi …
Expression characterization and functional implication of the collagen-modifying Leprecan proteins in mouse gonadal tissue and mature sperm.
Zimmerman SM, Besio R, Heard-Lipsmeyer ME, Dimori M, Castagnola P, Swain FL, Gaddy D, Diekman AB, Morello R. Zimmerman SM, et al. AIMS Genet. 2018;5(1):24-40. doi: 10.3934/genet.2018.1.24. Epub 2018 Feb 7. AIMS Genet. 2018. PMID: 30417103 Free PMC article.
The Leprecan protein family which includes the prolyl 3-hydroxylase enzymes (P3H1, P3H2, and P3H3), the closely related cartilage-associated protein (CRTAP), and SC65 (Synaptonemal complex 65, aka P3H4, LEPREL4), is involved in the post-translational modification of fibril …
The Leprecan protein family which includes the prolyl 3-hydroxylase enzymes (P3H1, P3H2, and P3H3), the closely related cartilage-ass …
17 results