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Page 1
Pulmonary toxicity, cytotoxicity, and genotoxicity of submicron-diameter carbon fibers with different diameters and lengths.
Fujita K, Obara S, Maru J. Fujita K, et al. Toxicology. 2022 Jan 30;466:153063. doi: 10.1016/j.tox.2021.153063. Epub 2021 Dec 8. Toxicology. 2022. PMID: 34890706 Free article.
Submicron-diameter carbon fibers (SCFs) are a type of fine-diameter fibrous carbon material that can be used in various applications. ...
Submicron-diameter carbon fibers (SCFs) are a type of fine-diameter fibrous carbon material that can be used in various applications. …
Inhalation of dust accumulated on personal computer fans in the office may cause pathological effects by disrupting the metabolic activity of alveolar macrophages.
Jung W, Yoon C, Yang MJ, Yu T, Choi H, Kwon NC, Choi SJ, Kim BG, Hong SM, Choi CW, Lee JA, Park EJ. Jung W, et al. Toxicology. 2025 Dec;518:154247. doi: 10.1016/j.tox.2025.154247. Epub 2025 Aug 4. Toxicology. 2025. PMID: 40752543
OD contained various types of microplastics and non-protein particles, and several hydrophilic elements were bound to the OD. When aspirated OD via the pharynx for 90 days, blood levels of IP and K significantly decreased in male mice, but not in female mice. ...More impor …
OD contained various types of microplastics and non-protein particles, and several hydrophilic elements were bound to the OD. When as …
Toxicity of size separated chrysotile fibres: The relevance of the macrophage-endothelial axis crosstalk.
Mirata S, Almonti V, Passalacqua M, Vernazza S, Bassi AM, Di Giuseppe D, Gualtieri AF, Scarfì S. Mirata S, et al. Toxicology. 2025 Feb;511:154032. doi: 10.1016/j.tox.2024.154032. Epub 2024 Dec 13. Toxicology. 2025. PMID: 39674395
The complex mechanisms through which the mineral fibres induce toxicity are not yet completely understood. In this regard, the morphometric parameters of asbestos fibres (e.g., length, width, aspect ratio) are known for their fundamental role in determining the degr …
The complex mechanisms through which the mineral fibres induce toxicity are not yet completely understood. In this regard, the morpho …
Translocation of particle-laden alveolar macrophages and intra-alveolar granuloma formation in rats exposed to Ludox colloidal amorphous silica by inhalation.
Lee KP, Kelly DP. Lee KP, et al. Toxicology. 1993 Mar 19;77(3):205-22. doi: 10.1016/0300-483x(93)90161-k. Toxicology. 1993. PMID: 8384734
Many migrated particle-laden AMs were necrotic and released particles in the TBLN. The released particles were phagocytized by histiocytes and formed histiocytic granulomas. ...However, perivascular silicotic granulomas were developed with accumulation of tra …
Many migrated particle-laden AMs were necrotic and released particles in the TBLN. The released particles were phagocyt …
Four-week inhalation toxicity study in rats with nylon respirable fibers: rapid lung clearance.
Warheit DB, Webb TR, Reed KL, Hansen JF, Kennedy GL Jr. Warheit DB, et al. Toxicology. 2003 Nov 5;192(2-3):189-210. doi: 10.1016/s0300-483x(03)00304-4. Toxicology. 2003. PMID: 14580786
This inhalation toxicity study in rats was conducted to assess the hazard potential for workers inhaling Nylon respirable fibers. Groups of 48 male rats each were exposed, nose-only, 6h per day, 5 days per week, for 4 weeks to aerosols of uncoated, finish-free Nylon respir …
This inhalation toxicity study in rats was conducted to assess the hazard potential for workers inhaling Nylon respirable fibers. Gro …
In vitro assays to predict the pathogenicity of mineral fibers.
Mossman BT, Sesko AM. Mossman BT, et al. Toxicology. 1990 Jan-Feb;60(1-2):53-61. doi: 10.1016/0300-483x(90)90162-a. Toxicology. 1990. PMID: 2156357
For example, release of superoxide (O2-.) from alveolar macrophages (AMs) was increased (in comparison to that observed in untreated cells) after exposure to the fibers, crocidolite asbestos, erionite, Code 100 fiberglass and sepiolite. Riebeckite, mordenite and glass p …
For example, release of superoxide (O2-.) from alveolar macrophages (AMs) was increased (in comparison to that observed in untreated cells) …
Short-term crocidolite inhalation studies in mice: validation of an inhalation chamber.
Rihn B, Kauffer E, Martin P, Coulais C, Villa M, Bottin MC, Vigneron JC, Edorh A, Martinet N. Rihn B, et al. Toxicology. 1996 May 17;109(2-3):147-56. doi: 10.1016/0300-483x(96)03325-2. Toxicology. 1996. PMID: 8658545
A month later the mice showed typical inflammatory bronchoalveolar liquids with many polynucleated or activated macrophages and asbestos bodies. The burden of crocidolite fibers ranged from 345,000 to 1,300,000 fibers per mg of dried lung. This study demonstrates th …
A month later the mice showed typical inflammatory bronchoalveolar liquids with many polynucleated or activated macrophages and asbestos bod …
Effects of crocidolite asbestos on human bronchoepithelial-dependent fibroblast stimulation in coculture: the role of IL-6 and GM-CSF.
Lang DS, Schocker H, Hockertz S. Lang DS, et al. Toxicology. 2001 Feb 21;159(1-2):81-98. doi: 10.1016/s0300-483x(00)00415-7. Toxicology. 2001. PMID: 11250057
For this purpose, epithelial cells were pre-exposed to UICC crocidolite asbestos fibers or titanium dioxide (TiO2) particles for 96 h and subsequently cocultured with fibroblasts for additional 72 h. ...
For this purpose, epithelial cells were pre-exposed to UICC crocidolite asbestos fibers or titanium dioxide (TiO2) particles f …