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Year Number of Results
2016 2
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2018 3
2021 2
2022 3
2023 4

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16 results

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Page 1
Structural basis for Cas9 off-target activity.
Pacesa M, Lin CH, Cléry A, Saha A, Arantes PR, Bargsten K, Irby MJ, Allain FH, Palermo G, Cameron P, Donohoue PD, Jinek M. Pacesa M, et al. Cell. 2022 Oct 27;185(22):4067-4081.e21. doi: 10.1016/j.cell.2022.09.026. Cell. 2022. PMID: 36306733 Free PMC article.
De novo design of protein interactions with learned surface fingerprints.
Gainza P, Wehrle S, Van Hall-Beauvais A, Marchand A, Scheck A, Harteveld Z, Buckley S, Ni D, Tan S, Sverrisson F, Goverde C, Turelli P, Raclot C, Teslenko A, Pacesa M, Rosset S, Georgeon S, Marsden J, Petruzzella A, Liu K, Xu Z, Chai Y, Han P, Gao GF, Oricchio E, Fierz B, Trono D, Stahlberg H, Bronstein M, Correia BE. Gainza P, et al. Among authors: pacesa m. Nature. 2023 May;617(7959):176-184. doi: 10.1038/s41586-023-05993-x. Epub 2023 Apr 26. Nature. 2023. PMID: 37100904 Free PMC article.
The next generation's Frankenstein films.
Nguyen J, Newton MS, Strong M, Pačesa M, Cao B, Winter KA, Dutton-Regester K, Kingsley LJ. Nguyen J, et al. Among authors: pacesa m. Science. 2018 Jan 12;359(6372):170-171. doi: 10.1126/science.aas9105. Science. 2018. PMID: 29326265 No abstract available.
PAM-flexible genome editing with an engineered chimeric Cas9.
Zhao L, Koseki SRT, Silverstein RA, Amrani N, Peng C, Kramme C, Savic N, Pacesa M, Rodríguez TC, Stan T, Tysinger E, Hong L, Yudistyra V, Ponnapati MR, Jacobson JM, Church GM, Jakimo N, Truant R, Jinek M, Kleinstiver BP, Sontheimer EJ, Chatterjee P. Zhao L, et al. Among authors: pacesa m. Nat Commun. 2023 Oct 4;14(1):6175. doi: 10.1038/s41467-023-41829-y. Nat Commun. 2023. PMID: 37794046 Free PMC article.
PAM-Flexible Genome Editing with an Engineered Chimeric Cas9.
Koseki S, Hong L, Yudistyra V, Stan T, Tysinger E, Silverstein R, Kramme C, Amrani N, Savic N, Pacesa M, Rodriguez T, Ponnapati M, Jacobson J, Church G, Truant R, Jinek M, Kleinstiver B, Sontheimer E, Chatterjee P. Koseki S, et al. Among authors: pacesa m. Res Sq. 2023 Mar doi: 10.21203/ Preprint. Res Sq. 2023. PMID: 36945419 Free PMC article. Updated.
NextGen VOICES: Research resolutions.
Olmeta-Schult F, Segal LM, Tyner S, Moon TA, Chow RD, Chakrabarty P, Pacesa M, Podgornaia AI, Chen J, Singh B, Cao B, Sidhu RRS, Tan BWQ, Sood P, Parker S, Scult MA, Van Haute D, Konstantinides N, Schwendimann BA, Srivastava S, Fiorenza R, Dutton-Regester K, Hale R, Polat EO, Lau E, Mayer AL, White ER. Olmeta-Schult F, et al. Among authors: pacesa m. Science. 2018 Jan 5;359(6371):26-28. doi: 10.1126/science.aar7504. Science. 2018. PMID: 29301998 No abstract available.
In vivo adenine base editing of PCSK9 in macaques reduces LDL cholesterol levels.
Rothgangl T, Dennis MK, Lin PJC, Oka R, Witzigmann D, Villiger L, Qi W, Hruzova M, Kissling L, Lenggenhager D, Borrelli C, Egli S, Frey N, Bakker N, Walker JA 2nd, Kadina AP, Victorov DV, Pacesa M, Kreutzer S, Kontarakis Z, Moor A, Jinek M, Weissman D, Stoffel M, van Boxtel R, Holden K, Pardi N, Thöny B, Häberle J, Tam YK, Semple SC, Schwank G. Rothgangl T, et al. Among authors: pacesa m. Nat Biotechnol. 2021 Aug;39(8):949-957. doi: 10.1038/s41587-021-00933-4. Epub 2021 May 19. Nat Biotechnol. 2021. PMID: 34012094 Free PMC article.
Conformational control of Cas9 by CRISPR hybrid RNA-DNA guides mitigates off-target activity in T cells.
Donohoue PD, Pacesa M, Lau E, Vidal B, Irby MJ, Nyer DB, Rotstein T, Banh L, Toh MS, Gibson J, Kohrs B, Baek K, Owen ALG, Slorach EM, van Overbeek M, Fuller CK, May AP, Jinek M, Cameron P. Donohoue PD, et al. Among authors: pacesa m. Mol Cell. 2021 Sep 2;81(17):3637-3649.e5. doi: 10.1016/j.molcel.2021.07.035. Mol Cell. 2021. PMID: 34478654 Free article.
16 results