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Year Number of Results
2002 2
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2009 8
2010 6
2011 6
2012 17
2013 8
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2017 22
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257 results

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Page 1
Loss of PADI2 and PADI4 ameliorates sepsis-induced acute lung injury by suppressing NLRP3+ macrophages.
Yu X, Song Y, Dong T, Ouyang W, Shao L, Quan C, Lee KE, Tan T, Tsung A, Kurabayashi K, Alam HB, Zhang M, Ma J, Li Y. Yu X, et al. JCI Insight. 2024 Nov 22;9(22):e181686. doi: 10.1172/jci.insight.181686. JCI Insight. 2024. PMID: 39405117 Free PMC article.
Our study shows that Padi2-/- Padi4-/- double KO (DKO) improved survival, reduced lung injury, and decreased bacterial load in Pseudomonas aeruginosa (PA) pneumonia-induced sepsis mice. Using single-cell RNA-Seq (scRNA-Seq), we found that the deletion of Padi2 and P …
Our study shows that Padi2-/- Padi4-/- double KO (DKO) improved survival, reduced lung injury, and decreased bacterial load in Pseudo …
Icaritin inhibits the progression of urothelial cancer by suppressing PADI2-mediated neutrophil infiltration and neutrophil extracellular trap formation.
Mou Z, Chen Y, Hu J, Hu Y, Zou L, Chen X, Liu S, Yin Q, Gong J, Li S, Mao S, Xu C, Jiang H. Mou Z, et al. Acta Pharm Sin B. 2024 Sep;14(9):3916-3930. doi: 10.1016/j.apsb.2024.06.029. Epub 2024 Jul 1. Acta Pharm Sin B. 2024. PMID: 39309483 Free PMC article.
Mechanistically, ICT binds to and inhibits the expression of PADI2 in neutrophils, thereby suppressing PADI2-mediated histone citrullination. Moreover, ICT inhibits ROS generation, suppresses the MAPK signaling pathway, and inhibits NET-induced tumor metastasis. Sim …
Mechanistically, ICT binds to and inhibits the expression of PADI2 in neutrophils, thereby suppressing PADI2-mediated histone …
PADI2 exacerbates Mycoplasma ovipneumoniae-induced lung injury in sheep by suppressing M2 macrophage polarization.
Yan C, Dong T, Zhang C, Liu M, Zhang Y. Yan C, et al. Vet Res. 2025 Oct 27;56(1):203. doi: 10.1186/s13567-025-01632-7. Vet Res. 2025. PMID: 41146353 Free PMC article.
In an in vitro coculture system, inhibition of PADI2 expression in BMDMs reduced apoptotic and intracellular reactive oxygen species (ROS) levels in lung fibroblasts. Interestingly, correlation analysis between the tracheal MO load and PADI2 expression in the bronch …
In an in vitro coculture system, inhibition of PADI2 expression in BMDMs reduced apoptotic and intracellular reactive oxygen species …
Peptidyl Arginine Deiminase 2 (PADI2)-Mediated Arginine Citrullination Modulates Transcription in Cancer.
Beato M, Sharma P. Beato M, et al. Int J Mol Sci. 2020 Feb 17;21(4):1351. doi: 10.3390/ijms21041351. Int J Mol Sci. 2020. PMID: 32079300 Free PMC article. Review.
Here, we review the recently discovered functions of PADI2-mediated citrullination of the C-terminal domain of RNA polymerase II in transcriptional regulation in breast cancer cells and the proposed mechanisms to reshape the transcription regulatory network that promotes c …
Here, we review the recently discovered functions of PADI2-mediated citrullination of the C-terminal domain of RNA polymerase II in t …
Targeting PADI2 as a potential therapeutic strategy against metastasis in oral cancer via suppressing EMT-mediated migration and invasion and CCL3/5-induced angiogenesis.
Hung SK, Yu CC, Lin HY, Chiou WY, Lee MS, Lin RI, Lu MC. Hung SK, et al. Clin Exp Metastasis. 2024 Dec;41(6):925-935. doi: 10.1007/s10585-024-10310-5. Epub 2024 Aug 31. Clin Exp Metastasis. 2024. PMID: 39215870
The effect of PADI2 on EMT was evaluated using cell lines by Western blot analysis with shRNA targeting PADI2. In addition, the selective PADI2 inhibitor AFM32a was used to assess the effect of PADI2 on cancer metastasis and angiogenesis in animal mode …
The effect of PADI2 on EMT was evaluated using cell lines by Western blot analysis with shRNA targeting PADI2. In addition, th …
Padi2/3 Deficiency Alters the Epigenomic Landscape and Causes Premature Differentiation of Mouse Trophoblast Stem Cells.
Ballasy NN, Bering EA, Kokorudz C, Radford BN, Zhao X, Dean W, Hemberger M. Ballasy NN, et al. Cells. 2022 Aug 9;11(16):2466. doi: 10.3390/cells11162466. Cells. 2022. PMID: 36010543 Free PMC article.
Interestingly, Padi2/3 DKO TSCs display alterations to their epigenomic landscape, with fewer H3K9me3-marked chromocentric foci and globally reduced 5-methylcytosine levels. ...As a consequence of the hypomethylated state, these factors are up-regulated in Padi2/3 D …
Interestingly, Padi2/3 DKO TSCs display alterations to their epigenomic landscape, with fewer H3K9me3-marked chromocentric foci and g …
PADI2-Catalyzed MEK1 Citrullination Activates ERK1/2 and Promotes IGF2BP1-Mediated SOX2 mRNA Stability in Endometrial Cancer.
Xue T, Liu X, Zhang M, E Q, Liu S, Zou M, Li Y, Ma Z, Han Y, Thompson P, Zhang X. Xue T, et al. Adv Sci (Weinh). 2021 Jan 29;8(6):2002831. doi: 10.1002/advs.202002831. eCollection 2021 Mar. Adv Sci (Weinh). 2021. PMID: 33747724 Free PMC article.
However, a role for PADI2 in endometrial cancer (EC) has not been previously explored. This study demonstrates that PADI2 is positively associated with EC proregression. ...Finally, PADI2 gene silencing, inhibiting MEK1 citrullination by PADI2 inhibito …
However, a role for PADI2 in endometrial cancer (EC) has not been previously explored. This study demonstrates that PADI2 is p …
PADI2-Mediated Citrullination Promotes Prostate Cancer Progression.
Wang L, Song G, Zhang X, Feng T, Pan J, Chen W, Yang M, Bai X, Pang Y, Yu J, Han J, Han B. Wang L, et al. Cancer Res. 2017 Nov 1;77(21):5755-5768. doi: 10.1158/0008-5472.CAN-17-0150. Epub 2017 Aug 17. Cancer Res. 2017. PMID: 28819028
PADI2 expression was required for survival and cell-cycle progression of prostate cancer cells, and PADI2 promoted proliferation of prostate cancer cells under androgen-deprived or castration conditions in vitro and in vivo Cytoplasmic PADI2 protected the and …
PADI2 expression was required for survival and cell-cycle progression of prostate cancer cells, and PADI2 promoted proliferati …
Molecular Factors in PAD2 (PADI2) and PAD4 (PADI4) Are Associated with Interstitial Lung Disease Susceptibility in Rheumatoid Arthritis Patients.
Nava-Quiroz KJ, Rojas-Serrano J, Pérez-Rubio G, Buendia-Roldan I, Mejía M, Fernández-López JC, Rodríguez-Henríquez P, Ayala-Alcantar N, Ramos-Martínez E, López-Flores LA, Del Ángel-Pablo AD, Falfán-Valencia R. Nava-Quiroz KJ, et al. Cells. 2023 Sep 8;12(18):2235. doi: 10.3390/cells12182235. Cells. 2023. PMID: 37759458 Free PMC article.
Moreover, rs1748033 in PADI4, rs2057094, and rs2076615 in PADI2 are associated with RA susceptibility. In conclusion, in RA patients, single nucleotide variants in PADI4 and PADI2 are associated with ILD susceptibility. The rs1748033 in PADI4 and two different SNVs …
Moreover, rs1748033 in PADI4, rs2057094, and rs2076615 in PADI2 are associated with RA susceptibility. In conclusion, in RA patients, …
Association of PADI2 and PADI4 polymorphisms in COVID-19 host severity and non-survival.
Gutiérrez-Pérez IA, Buendía-Roldán I, Zaragoza-García O, Pérez-Rubio G, Villafan-Bernal JR, Chávez-Galán L, Parra-Rojas I, Hernández-Zenteno RJ, Fricke-Galindo I, Castro-Alarcón N, Bautista-Becerril B, Falfán-Valencia R, Guzmán-Guzmán IP. Gutiérrez-Pérez IA, et al. Heliyon. 2024 Mar 15;10(6):e27997. doi: 10.1016/j.heliyon.2024.e27997. eCollection 2024 Mar 30. Heliyon. 2024. PMID: 38524554 Free PMC article.
The GTACC haplotype in PADI2-PADI4 was associated with susceptibility to severe COVID-19, while the GCACC haplotype was a protective factor. ...CONCLUSIONS: Our results suggest that the haplotypic combination of GTACC and some individual genotypes of PADI2 and PADI4 …
The GTACC haplotype in PADI2-PADI4 was associated with susceptibility to severe COVID-19, while the GCACC haplotype was a protective …
257 results