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The Gαi-GIV binding interface is a druggable protein-protein interaction.
DiGiacomo V, de Opakua AI, Papakonstantinou MP, Nguyen LT, Merino N, Blanco-Canosa JB, Blanco FJ, Garcia-Marcos M. DiGiacomo V, et al. Among authors: papakonstantinou mp. Sci Rep. 2017 Aug 17;7(1):8575. doi: 10.1038/s41598-017-08829-7. Sci Rep. 2017. PMID: 28819150 Free PMC article.
Specific inhibition of GPCR-independent G protein signaling by a rationally engineered protein.
Leyme A, Marivin A, Maziarz M, DiGiacomo V, Papakonstantinou MP, Patel PP, Blanco-Canosa JB, Walawalkar IA, Rodriguez-Davila G, Dominguez I, Garcia-Marcos M. Leyme A, et al. Among authors: papakonstantinou mp. Proc Natl Acad Sci U S A. 2017 Nov 28;114(48):E10319-E10328. doi: 10.1073/pnas.1707992114. Epub 2017 Nov 13. Proc Natl Acad Sci U S A. 2017. PMID: 29133411 Free PMC article.
A novel regulatory role of RGS4 in STAT5B activation, neurite outgrowth and neuronal differentiation.
Pallaki P, Georganta EM, Serafimidis I, Papakonstantinou MP, Papanikolaou V, Koutloglou S, Papadimitriou E, Agalou A, Tserga A, Simeonof A, Thomaidou D, Gaitanou M, Georgoussi Z. Pallaki P, et al. Among authors: papakonstantinou mp. Neuropharmacology. 2017 May 1;117:408-421. doi: 10.1016/j.neuropharm.2017.02.012. Epub 2017 Feb 17. Neuropharmacology. 2017. PMID: 28219718
The Prognostic Significance of Low-Frequency Somatic Mutations in Metastatic Cutaneous Melanoma.
Zhao X, Little P, Hoyle AP, Pegna GJ, Hayward MC, Ivanova A, Parker JS, Marron DL, Soloway MG, Jo H, Salazar AH, Papakonstantinou MP, Bouchard DM, Jefferys SR, Hoadley KA, Ollila DW, Frank JS, Thomas NE, Googe PB, Ezzell AJ, Collichio FA, Lee CB, Earp HS, Sharpless NE, Hugo W, Wilmott JS, Quek C, Waddell N, Johansson PA, Thompson JF, Hayward NK, Mann GJ, Lo RS, Johnson DB, Scolyer RA, Hayes DN, Moschos SJ. Zhao X, et al. Among authors: papakonstantinou mp. Front Oncol. 2019 Jan 4;8:584. doi: 10.3389/fonc.2018.00584. eCollection 2018. Front Oncol. 2019. PMID: 30662871 Free PMC article.